Abo Bibliothek: Guest
Journal of Environmental Pathology, Toxicology and Oncology

Erscheint 4 Ausgaben pro Jahr

ISSN Druckformat: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Assessment of the Therapeutic Effects of Fucoxanthin by Attenuating Inflammation in Ovalbumin-Induced Asthma in an Experimental Animal Model

Volumen 38, Ausgabe 3, 2019, pp. 229-238
DOI: 10.1615/JEnvironPatholToxicolOncol.2019030154
Get accessGet access

ABSTRAKT

Asthma has affected more than 300 million people worldwide and is considered one of the most debilitating global public health problems based on a recent statistical report from the Global Initiative for Asthma. Inflammation of the airways leads to the various interrelated mechanisms of innate and adaptive immunity acting mutually with the epithelium of the respiratory organ. Fucoxanthin is an orange or brown pigment which is naturally found in various seaweeds. To the best of our knowledge, there are no scientific claims or evidence of the curative effects of fucoxanthin against asthma. Hence, this present research was designed to investigate the curative activity of fucoxanthin against ovalbumin-induced asthma in a mouse model. Fucoxanthin (50 mg/kg) showed significant (P < 0.001) antiasthma activity. It effectively decreased intracellular secretion of reactive oxygen species and increased antioxidant enzyme activity. Fucoxanthin also decreased inflammatory cytokine markers in bronchoalveolar lavage fluid. Because fucoxanthin showed effective antiasthma activity against ovalbumin-induced asthma in experimental animals, further research on this natural antioxidant could lead to development of a novel drug for the treatment of asthma in humans.

REFERENZEN
  1. GINA. Global initiative for asthma, global strategy for asthma management and prevention. 2016. Accessed 7 Feb 2017. Available from: http://ginasthma.org/ 2016-gina-reportglobalstrategy-for-asthma-management-and-pre-vention.

  2. Reddel HK, Bateman ED, Becker A, Boulet LP, Cruz AA, Drazen JM, Haahtela T, Hurd SS, Inoue H, De Jongste JC, Lemanske RF. A summary of the new GINA strategy: a roadmap to asthma control. Eur Resp J. 2015 Sep 1;46(3):622-39.

  3. Costa E, Bregman M, Araujo DV, Costa CH, Rufino R. Asthma and the socio-economic reality in Brazil. World Allergy Organ J. 2013 Dec;6(1):1.

  4. Nunes C, Pereira AM, Morais-Almeida M. Asthma costs and social impact. Asthma Res Pract. 2017 Dec;3(1):1.

  5. Tiotiu A. Biomarkers in asthma: state of the art. Asthma Res Pract. 2018; 4(1):10.

  6. Rosa SI, Rios-Santos F, Balogun SO, de Almeida DA, Damazo AS, da Cruz TC, Pavan E, dos Santos Barbosa R, da Costa Alvim T, Soares IM, Ascencio SD. Hydroethanolic extract from Echinodorus scaber Rataj leaves inhibits inflammation in ovalbumin-induced allergic asthma. J Ethnopharmacol. 2017 May 5;203:191-9.

  7. Niemann B, Rohrbach S, Miller MR, Newby DE, Fuster V, Kovacic JC. Oxidative stress and cardiovascular risk: obesity, diabetes, smoking, and pollution. J Am College Cardiol. 2017 Jul 3;70(2):230-51.

  8. Hall S, Agrawal DK. Key mediators in the immunopath- ogenesis of allergic asthma. Int Immunopharmacol. 2014 Nov 1;23(1):316-29.

  9. Johnathan M, Gan SH, Ezumi MW, Faezahtul AH, Nurul AA. Phytochemical profiles and inhibitory effects of tiger milk mushroom (Lignosus rhinocerus) extract on ovalbumin-induced airway inflammation in a rodent model of asthma. BMC Comp Alt Med. 2016 Dec;16(1):167.

  10. Olaguibel JM, Quirce S, Julia B, Fernandez C, Fortuna AM, Molina J, Plaza V. Measurement of asthma control according to Global Initiative for Asthma guidelines: a comparison with the Asthma Control Questionnaire. Resp Res. 2012 Dec;13(1):50.

  11. Brand PL. Inhaled corticosteroids should be the first line of treatment for children with asthma. Paediatr Resp Rev. 2011 Dec 1;12(4):245-9.

  12. Chini L, Monteferrario E, Graziani S, Moschese V. Novel treatments of asthma and allergic diseases. Paediatr Resp Rev. 2014 Dec 1;15(4):355-62.

  13. Martin L. Fucoxanthin and its metabolite fucoxanthinol in cancer prevention and treatment. Marine Drugs. 2015 Aug;13(8):4784-98.

  14. Rengarajan T, Rajendran P, Nandakumar N, Balasu-bramanian M, Nishigaki I. Cancer preventive efficacy of marine carotenoid fucoxanthin: cell cycle arrest and apoptosis. Nutrients. 2013 Dec;5(12):4978-89.

  15. Chuyen HV, Eun JB. Marine carotenoids: Bioactivities and potential benefits to human health. Crit Rev Food Sci Nutr. 2017 Aug 13;57(12):2600-10.

  16. Zaharudin N, Staerk D, Dragsted LO. Inhibition of a-glucosidase activity by selected edible seaweeds and fucox-anthin. Food Chem. 2019 Jan 1;270:481-6.

  17. Gammone M, D'Orazio N. Anti-obesity activity of the marine carotenoid fucoxanthin. Marine Drugs. 2015;13(4): 2196-214.

  18. Zorofchian Moghadamtousi S, Karimian H, Khanabdali R, Razavi M, Firoozinia M, Zandi K, Abdul Kadir H. Anticancer and antitumor potential of fucoidan and fucox-anthin, two main metabolites isolated from brown algae. Sci World J. 2014;2014.

  19. Kumar S, Hosokawa M, Miyashita K. Fucoxanthin: marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms. Marine Drugs. 2013;11(12):5130-47.

  20. Hajrezaie M, Golbabapour S, Hassandarvish P, Gwaram NS, Hadi AH, Ali HM, Majid N, Abdulla MA. Acute toxicity and gastroprotection studies of a new schiff base derived copper (II) complex against ethanol-induced acute gastric lesions in rats. PLoS One. 2012 Dec 10;7(12):e51537.

  21. Kakkar P, Das B, Viswanathan PN. A modified spectro-photometric assay of superoxide dismutase. Ind J Biochem Biophys. 1984;21(2):130-2.

  22. Beers RF, Sizer IW. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem. 1952 Mar 1;195(1):133-40.

  23. Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Analy Biochem. 1968 Jan 1;25:192-205.

  24. Centers for Disease Control and Prevention. Chronic diseases: the leading causes of death and disability in the United States. 2015. Available from: https://www.cdc.gov/ chronicdisease/about/index.htm.

  25. Bhat YA, Rehman R, Mabalirajan U. Pathophysiology of asthma. Pathophysiology. 2017 Nov;5(X1).

  26. Bialas AJ, Sitarek P, Milkowska-Dymanowska J, Piotrowski WJ, Gorski P. The role of mitochondria and oxidative/antioxidative imbalance in pathobiology of chronic obstructive pulmonary disease. Oxidat Med Cel-lular Long. 2016;2016.

  27. MacNee W. Pulmonary and systemic oxidant/antioxidant imbalance in chronic obstructive pulmonary disease. Proc Am Thoracic Soc. 2005 Apr;2(1):50-60.

  28. Lanza GM, Jenkins J, Schmieder AH, Moldobaeva A, Cui G, Zhang H, Yang X, Zhong Q, Keupp J, Sergin I, Paranandi KS. Anti-angiogenic nanotherapy inhibits airway remodeling and hyper-responsiveness of dust mite triggered asthma in the Brown Norway rat. Theranostics. 2017;7(2):377.

  29. Madigan LA, Gordon EM, Levine SJ, Druey KM, Wong G. Rgs4 attenuates allergen-induced airway hyper-responsiveness in mice. Am J Respir Crit Care Med. 2017;195:A5296.

  30. Liu T, Liu Y, Miller M, Cao L, Zhao J, Wu J, Wang J, Liu L, Li S, Zou M, Xu J. Autophagy plays a role in FSTL1-induced EMT and airway remodeling in asthma. Am J Physiol-Heart Circ Physiol. 2017 May 4:L27-40.

  31. Miyagawa M, Satou T, Yukimune C, Ishibashi A, Seimiya H, Yamada H, Hasegawa T, Koike K. Anxiolytic-like effect of illicium verum fruit oil, trans-anethole and related compounds in mice. Phytother Res. 2014 Nov;28(11):1710-2.

  32. He Y, Lou X, Jin Z, Yu L, Deng L, Wan H. Mahuang decoction mitigates airway inflammation and regulates IL-21/STAT3 signaling pathway in rat asthma model. J Ethnopharmacol. 2018 Oct 5;224:373-80.

  33. Matsuno T. Aquatic animal carotenoids. Fisheries Sci. 2001;67(5):771-83.

REFERENZIERT VON
  1. Li Shenrui, Zheng Xiaoyun, Fang Qingshu, Gong Yifu, Wang Heyu, Exploring the potential of photosynthetic induction factor for the commercial production of fucoxanthin in Phaeodactylum tricornutum, Bioprocess and Biosystems Engineering, 44, 8, 2021. Crossref

  2. Ávila-Román Javier, García-Gil Sara, Rodríguez-Luna Azahara, Motilva Virginia, Talero Elena, Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids, Marine Drugs, 19, 10, 2021. Crossref

  3. Khalil Ayman, Tazeddinova Diana, Aljoumaa Khaled, Kazhmukhanbetkyzy Zhumayeva Araigul, Orazov Ayan, Toshev Abduvali Djabarovich, Carotenoids: Therapeutic Strategy in the Battle against Viral Emerging Diseases, COVID-19: An Overview, Preventive Nutrition and Food Science, 26, 3, 2021. Crossref

  4. Zhong Jia-Ze, Liao Yu-Qin, She Qiu-Tian, Xue Ting, You Rui-Yun, Chen You-Qiang, Huang Lu-Qiang, Rapid and sensitive label-free SERS determination of fucoxanthin in algae using gold nanoparticles, Optical Materials Express, 11, 2, 2021. Crossref

  5. Wu Shu-Ju, Liou Chian-Jiun, Chen Ya-Ling, Cheng Shu-Chen, Huang Wen-Chung, Fucoxanthin Ameliorates Oxidative Stress and Airway Inflammation in Tracheal Epithelial Cells and Asthmatic Mice, Cells, 10, 6, 2021. Crossref

  6. Ávila-Román Javier, Talero Elena, Rodríguez-Luna Azahara, García-Gil Sara, Jiménez-Gordillo María Dolores, Motilva Virginia, Microalgal bioactive components as antiinflammatory and antioxidant agents for health promotion, in Current Advances for Development of Functional Foods Modulating Inflammation and Oxidative Stress, 2022. Crossref

  7. Mohibbullah Md., Haque Md. Nazmul, Sohag Abdullah Al Mamun, Hossain Md. Tahmeed, Zahan Md. Sarwar, Uddin Md. Jamal, Hannan Md. Abdul, Moon Il Soo, Choi Jae-Suk, A Systematic Review on Marine Algae-Derived Fucoxanthin: An Update of Pharmacological Insights, Marine Drugs, 20, 5, 2022. Crossref

  8. Lu Louise W., Gao Yao, Quek Siew-Young, Foster Meika, Eason Charles T., Liu Min, Wang Mingfu, Chen Jie-Hua, Chen Feng, The landscape of potential health benefits of carotenoids as natural supportive therapeutics in protecting against Coronavirus infection, Biomedicine & Pharmacotherapy, 154, 2022. Crossref

Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen Preise und Aborichtlinien Begell House Kontakt Language English 中文 Русский Português German French Spain