Abo Bibliothek: Guest
Journal of Environmental Pathology, Toxicology and Oncology

Erscheint 4 Ausgaben pro Jahr

ISSN Druckformat: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Effect of Amentoflavone, a Phenolic Component From Biophytum sensitivum, on Cell Cycling and Apoptosis of B16F-10 Melanoma Cells

Volumen 30, Ausgabe 4, 2011, pp. 301-309
DOI: 10.1615/JEnvironPatholToxicolOncol.v30.i4.30
Get accessGet access

ABSTRAKT

Flavanoids are polyphenolic compounds that are found in fruits and vegetables and have diverse, beneficial biochemical and antioxidant effects. The objective of this study was to assess the effect of amentoflavone, a biflavanoid isolated from Biophytum sensitivum, on cell cycling distribution and apoptosis in B16F-10 melanoma cells. Treatment of B16F-10 melanoma cells with amentoflavone (10 μg/mL) increased cells in the sub-G0/G1 phase accompanied by a decrease in G0/G1 phase cells in a time-dependent manner. A terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay of amentoflavone-treated B16F-10 melanoma cells confirmed that the cells were undergoing apoptosis. Amentoflavone was found to significantly inhibit B16F-10 melanoma-induced solid tumor development in C57BL/6 mice. The increase in apoptotic cells in paraffin sections obtained from amentoflavone-treated animals indicates that the reduction may be mediated through induction of apoptosis. Murine cell cycle-regulating genes, such as p21 and p27, and apoptosis-regulating genes, such as Bax and caspase-9, were found to be upregulated, whereas cyclin D1 and Bid were downregulated in amentoflavone-treated cells. These results demonstrate that amentoflavone can induce apoptosis via inhibiting progression of cells from G0/G1 to S phase and regulating genes involved in cell cycle regulation and apoptotic intrinsic pathways.

REFERENZIERT VON
  1. Oh Jueun, Rho Ho Sik, Yang Yanyan, Yoon Ju Young, Lee Jongsung, Hong Yong Deog, Kim Hyeon Chung, Choi Sun Shim, Kim Tae Woong, Shin Song Seok, Cho Jae Youl, Extracellular Signal-Regulated Kinase Is a Direct Target of the Anti-Inflammatory Compound Amentoflavone Derived fromTorreya nucifera, Mediators of Inflammation, 2013, 2013. Crossref

  2. Zhang Zhen, Sun Tao, Niu Jian-guo, He Zhen-quan, Liu Yang, Wang Feng, Amentoflavone protects hippocampal neurons: anti-inflammatory, antioxidative, and antiapoptotic effects, Neural Regeneration Research, 10, 7, 2015. Crossref

  3. An Jingang, Li Zhengxiao, Dong Yingying, Ren Jianwen, Huo Jia, Amentoflavone protects against psoriasis-like skin lesion through suppression of NF-κB-mediated inflammation and keratinocyte proliferation, Molecular and Cellular Biochemistry, 413, 1-2, 2016. Crossref

  4. Stamellou Eleni, Fontana Johann, Wedel Johannes, Ntasis Emmanouil, Sticht Carsten, Becker Anja, Pallavi Prama, Wolf Kerstin, Krämer Bernhard K., Hafner Mathias, van Son Willem J., Yard Benito A., Ablonczy Zsolt, N-Octanoyl Dopamine Treatment of Endothelial Cells Induces the Unfolded Protein Response and Results in Hypometabolism and Tolerance to Hypothermia, PLoS ONE, 9, 6, 2014. Crossref

  5. Qin Li, Zhao Ying, Zhang Bin, Li Yan, Amentoflavone improves cardiovascular dysfunction and metabolic abnormalities in high fructose and fat diet-fed rats, Food & Function, 9, 1, 2018. Crossref

  6. Yu Sheng, Yan Hui, Zhang Li, Shan Mingqiu, Chen Peidong, Ding Anwei, Li Sam, A Review on the Phytochemistry, Pharmacology, and Pharmacokinetics of Amentoflavone, a Naturally-Occurring Biflavonoid, Molecules, 22, 2, 2017. Crossref

  7. Chen Guangyong, Han Yangdong, He Wang, Liang Feng, Amentoflavone protects against high fat-induced metabolic dysfunction: Possible role of the regulation of adipogenic differentiation, International Journal of Molecular Medicine, 38, 6, 2016. Crossref

  8. Gao Jiayu, Yang Xiao, Yin Weiping, Li Ming, Gallnuts: A Potential Treasure in Anticancer Drug Discovery, Evidence-Based Complementary and Alternative Medicine, 2018, 2018. Crossref

  9. González‐Ruiz Lucia, González‐Moles Miguel Ángel, González‐Ruiz Isabel, Ruiz‐Ávila Isabel, Ayén Ángela, Ramos‐García Pablo, An update on the implications of cyclin D1 in melanomas, Pigment Cell & Melanoma Research, 33, 6, 2020. Crossref

  10. Xiong Xifeng, Tang Nan, Lai Xudong, Zhang Jinli, Wen Weilun, Li Xiaojian, Li Aiguo, Wu Yanhua, Liu Zhihe, Insights Into Amentoflavone: A Natural Multifunctional Biflavonoid, Frontiers in Pharmacology, 12, 2021. Crossref

  11. Greco Giulia, Catanzaro Elena, Fimognari Carmela, Natural Products as Inducers of Non-Canonical Cell Death: A Weapon against Cancer, Cancers, 13, 2, 2021. Crossref

  12. Sharma Anjali, Swetha Rayala, Bajad Nilesh Gajanan, Ganeshpurkar Ankit, Singh Ravi, Kumar Ashok, Singh Sushil Kumar, Cathepsin B-A Neuronal Death Mediator in Alzheimer’s Disease Leading to Neurodegeneration, Mini-Reviews in Medicinal Chemistry, 22, 15, 2022. Crossref

Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen Preise und Aborichtlinien Begell House Kontakt Language English 中文 Русский Português German French Spain