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ISSN Druckformat: 0731-8898
ISSN Online: 2162-6537
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Photodynamic Therapy of Nodular Basal Cell Carcinoma with Multifiber Contact Light Delivery
ABSTRAKT
To overcome the limited treatment depth of superficial photodynamic therapy we investigate interstitial light delivery. In the present work the treatment light was delivered using a system in which three or six clear-cut fibers were placed in direct contact with the tumor area. This placement was thought to represent a step toward general purpose interstitial PDT. Twelve nodular basal cell carcinomas were treated employing δ-aminolevulinic acid and 635 nm laser irradiation. Fluorescence measurements were performed monitoring the buildup and subsequent bleaching of the produced sensitizer protoporphyrin IX. The treatment efficacy, judged at a 28-month follow-up, showed a 100% complete response. Two punch excisions at 7 months converted two partial responses to complete responses. One patient failed to appear at all follow-up sessions. The outcome of the treatments was comparable to superficial photodynamic therapy in terms of histological, clinical, and cosmetic results.
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Ross Kate, Cherpelis Basil, Lien Mary, Fenske Neil, Spotlighting the Role of Photodynamic Therapy in Cutaneous Malignancy: An Update and Expansion, Dermatologic Surgery, 39, 12, 2013. Crossref
-
Johansson Ann, Johansson Thomas, Thompson Marcelo Soto, Bendsoe Niels, Svanberg Katarina, Svanberg Sune, Andersson-Engels Stefan, In vivo measurement of parameters of dosimetric importance during interstitial photodynamic therapy of thick skin tumors, Journal of Biomedical Optics, 11, 3, 2006. Crossref
-
Sibani Stéphane A, McCarron Paul A, Woolfson A David, Donnelly Ryan F, Photosensitiser delivery for photodynamic therapy. Part 2: systemic carrier platforms, Expert Opinion on Drug Delivery, 5, 11, 2008. Crossref
-
MacCormack Mollie A., Photodynamic Therapy in Dermatology: An Update on Applications and Outcomes, Seminars in Cutaneous Medicine and Surgery, 27, 1, 2008. Crossref
-
Donnelly Ryan F., Morrow Desmond I.J., McCarron Paul A., Garland Martin J., Woolfson A. David, Influence of solution viscosity and injection protocol on distribution patterns of jet injectors: Application to photodynamic tumour targeting, Journal of Photochemistry and Photobiology B: Biology, 89, 2-3, 2007. Crossref
-
Andersson-Engels Stefan, Axelsson Johan, Johansson Ann, Johansson Jonas, Svanberg Sune, Svensson Tomas, Time-of-flight laser spectroscopy in biomedical diagnostics, 2007 Asia Optical Fiber Communication and Optoelectronics Conference, 2007. Crossref
-
Johansson Ann, Andersson-Engels Stefan, Photodynamic Therapy - the Quest for Improved Dosimetry in the Management of Solid Tumors, in Laser Imaging and Manipulation in Cell Biology, 2010. Crossref
-
Ye Xuying, Yin Huijuan, Lu Yu, Zhang Haixia, Wang Han, Evaluation of Hydrogel Suppositories for Delivery of 5-Aminolevulinic Acid and Hematoporphyrin Monomethyl Ether to Rectal Tumors, Molecules, 21, 10, 2016. Crossref
-
Kaniyala Melanthota Sindhoora, Kistenev Yury V., Borisova Ekaterina, Ivanov Deyan, Zakharova Olga, Boyko Andrey, Vrazhnov Denis, Gopal Dharshini, Chakrabarti Shweta, K Shama Prasada, Mazumder Nirmal, Types of spectroscopy and microscopy techniques for cancer diagnosis: a review, Lasers in Medical Science, 37, 8, 2022. Crossref