Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Journal of Environmental Pathology, Toxicology and Oncology
Impact-faktor: 1.241 5-jähriger Impact-Faktor: 1.349 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN Druckformat: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvPathToxOncol.v22.i1.70
8 pages

Bioassay-Guided Isolation of Antimutagenic Factors from Fruits of Terminalia Bellerica

Swayamjot Kaur
Department of Botanical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India
Saroj Arora
Department of Botanical Sciences, Guru Nanak Dev University, Amritsar 143 005, Punjab, India
Satwinderjeet Kaur
Department of Botanical Sciences, Guru Nanak Dev University, Amritsar, India
Subodh Kumar
Department of Chemistry, Guru Nanak Dev University, Amritsar, Punjab, India

ABSTRAKT

In the course of our search for novel polyphenolic antimutagenic agents from medicinal plants, we examined water, acetone, and chloroform extracts of Terminalia bellerica for their antimutagenic potency using the Ames Salmonella/microsome assay. Acetone extract exhibited variable inhibitory activity of 65.6%, and 69.7% with 4–O–nitrophenylenediamine (NPD) and sodium azide, respectively (as direct-acting mutagens), and 81.4% with 2–aminofluorene (2AF) (an S9-dependent mutagen), in the preincubation mode of experimentation. Inhibition with chloroform and water extracts was rather insignificant. Studies are well underway to isolate and identify the active polyphenolic compounds from acetone extract, which could be used as effective chemopreventive agents in the future.


Articles with similar content:

Antimutagenic Potential of Extracts Isolated from Terminalia Arjuna
Journal of Environmental Pathology, Toxicology and Oncology, Vol.20, 2001, issue 1
Subodh Kumar, Satwinderjeet Kaur, Iqbal S. Grover
Antiproliferative Activity of Some Higher Mushrooms from Hungary against Human Cancer Cell Lines
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 12
Attila Vanyolos, Istvan Zupko, Noemi Bozsity, Judit Hohmann, Bernadett Kovacs
The Effect of Culture Liquid Ethyl Acetate Mycelium Extracts of Medicinal Mushrooms on the Viability of Human Pancreatic Cancer Cells
International Journal of Medicinal Mushrooms, Vol.14, 2012, issue 2
Solomon P. Wasser, Lital E. Sharvit, Fuad Fares
Cytotoxicity of Blended Versus Single Medicinal Mushroom Extracts on Human Cancer Cell Lines: Contribution of Polyphenol and Polysaccharide Content
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 5
Jasna Franekic, Neven Jakopovich, Ivan Jakopovich, Drazenka Komes, Ksenija Durgo, Boris Jakopovic, Ana Belscak-Cvitanovic, Mladen Koncar
Selective Cytotoxic Activity of Se-Methyl-Seleno-L-Cysteine– and Se-Polysaccharide–Containing Extracts from Shiitake Medicinal Mushroom, Lentinus edodes (Agaricomycetes)
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 8
Maciej Dawidowski, Iwonna Rahden-Staroń, Marzenna Klimaszewska, Jadwiga Turło, Agnieszka Szczepanska, Dagmara Kurpios-Piec, Emilia Orzechowska, Piotr Podsadni, Emilia Grosicka-Maciag, Sandra Górska