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ISSN Druckformat: 0731-8898
ISSN Online: 2162-6537
Indexed in
Studies on Correlation of Antimutagenic and Antiproliferative Activities of Juglans regia L.
ABSTRAKT
We investigated the effect of water and acetone extract of Juglans regia L. to evaluate its antimutagenic and antiproliferative activities. The antimutagenic study using TA98 and TA100 tester strains of Salmonella revealed the water and acetone extracts to be more effective than the benzene and chloroform extracts in inhibiting the revertants induced by 2–aminoflourene (2AF) in TA100 tester strains. The most effective extracts in the Ames assay were further evaluated using the Lucifer luciferase assay and in time course studies for antiproliferative activities using the Hoechst staining to observe apoptotic cell deaths. The acetone extract showed a correlation of antimutagenic activities in the Ames assay with its antiproliferative effect in different cell lines, while the water extract exerted its effect distinctly in each cell line. Further studies are still needed to evaluate the cytotoxicity in experiments carried out in vivo.
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Kaileh Mary, Berghe Wim Vanden, Boone Elke, Essawi Tamer, Haegeman Guy, Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity, Journal of Ethnopharmacology, 113, 3, 2007. Crossref
-
Carvalho Márcia, Ferreira Pedro J., Mendes Vanda S., Silva Renata, Pereira José A., Jerónimo Carmen, Silva Branca M., Human cancer cell antiproliferative and antioxidant activities of Juglans regia L., Food and Chemical Toxicology, 48, 1, 2010. Crossref
-
Vahdati K., Sarikhani Khorami S., Arab M.M., Walnut: a potential multipurpose nut crop for reclaiming deteriorated lands and environment, Acta Horticulturae, 1190, 2018. Crossref
-
Haque R, Bin-Hafeez B, Parvez S, Pandey S, Sayeed I, Ali M, Raisuddin S, Aqueous extract of walnut (Juglans regia L.) protects mice against cyclophosphamideinduced biochemical toxicity, Human & Experimental Toxicology, 22, 9, 2003. Crossref
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Chudhary Zarghouna, Khera Rasheed Ahmad, Hanif Muhammad Asif, Ayub Muhammad Adnan, Hamrouni Lamia, Walnut, in Medicinal Plants of South Asia, 2020. Crossref
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