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Journal of Environmental Pathology, Toxicology and Oncology

Erscheint 4 Ausgaben pro Jahr

ISSN Druckformat: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Baicalein Inhibits MCF-7 Cell Proliferation In Vitro, Induces Radiosensitivity, and Inhibits Hypoxia Inducible Factor

Volumen 34, Ausgabe 4, 2015, pp. 299-308
DOI: 10.1615/JEnvironPatholToxicolOncol.2015013806
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ABSTRAKT

Hypoxia inducible factor (HIF) is a key transcription factor responsible for imparting adaptability to the cancer cells growing in tumors. HIF induces the modulation of glucose metabolism, angiogenesis, and prosurvival signaling. Therefore, HIF is one of the attractive targets to treat solid tumors. Results presented in this study indicate that Baicalein (BA) inhibits HIF stabilization and also reduces its transcription activity in MCF-7 cells in vitro. Furthermore, BA was found to have antiproliferative ability as determined by the MTT assay and clonogenic survival. BA also induces apoptosis in MCF-7 cells at the concentration of 50 µM. We also report the radiosensitization of MCF-7 cells when they are treated with BA, resulting in higher γ-radiation−induced DNA damage. BA is extensively used in Chinese medicine and is known to be nontoxic at pharmacological doses. Our studies indicate that BA is one of the attractive natural compounds suitable for further evaluation as an adjuvant therapy.

REFERENZIERT VON
  1. Yang Guozi, Li Wei, Jiang Hongyu, Liang Xinyue, Zhao Yuguang, Yu Dehai, Zhou Lei, Wang Guanjun, Tian Huimin, Han Fujun, Cai Lu, Cui Jiuwei, Low-dose radiation may be a novel approach to enhance the effectiveness of cancer therapeutics, International Journal of Cancer, 139, 10, 2016. Crossref

  2. Shin Soon, Lee Youngshim, Kim Beom, Lee Junho, Ahn Seunghyun, Koh Dongsoo, Lim Yoongho, Lee Young, Inhibitory Effect of Synthetic Flavone Derivatives on Pan-Aurora Kinases: Induction of G2/M Cell-Cycle Arrest and Apoptosis in HCT116 Human Colon Cancer Cells, International Journal of Molecular Sciences, 19, 12, 2018. Crossref

  3. Su Guangfeng, Chen Hao, Sun Xinhua, Baicalein suppresses non small cell lung cancer cell proliferation, invasion and Notch signaling pathway, Cancer Biomarkers, 22, 1, 2018. Crossref

  4. Gandhi Nitin Motilal, Cellular adaptive response and regulation of HIF after low dose gamma-radiation exposure, International Journal of Radiation Biology, 94, 9, 2018. Crossref

  5. Xu Jing, Liu Dandan, Xiao Shengxiang, Meng Xinxin, Zhao Di, Jiang Xin, Jiang Xue, Cai Lu, Jiang Hongyu, Low-Dose Radiation Prevents Chemotherapy-Induced Cardiotoxicity, Current Stem Cell Reports, 5, 2, 2019. Crossref

  6. Deng Xiangping, Peng Yijiao, Zhao Jingduo, Lei Xiaoyong, Zheng Xing, Xie Zhizhong, Tang Guotao, Anticancer Activity of Natural Flavonoids: Inhibition of HIF-1α Signaling Pathway, Current Organic Chemistry, 23, 26, 2020. Crossref

  7. Pralea Ioana-Ecaterina, Petrache Alina-Maria, Tigu Adrian Bogdan, Gulei Diana, Moldovan Radu-Cristian, Ilieș Maria, Nicoară Raul, Hegheș Simona-Codruța, Uifălean Alina, Iuga Cristina-Adela, Phytochemicals as Regulators of Tumor Glycolysis and Hypoxia Signaling Pathways: Evidence from In Vitro Studies, Pharmaceuticals, 15, 7, 2022. Crossref

  8. Gong Wei-yi, Zhao Zheng-xiao, Liu Bao-jun, Lu Lin-wei, Dong Jing-cheng, Exploring the chemopreventive properties and perspectives of baicalin and its aglycone baicalein in solid tumors, European Journal of Medicinal Chemistry, 126, 2017. Crossref

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