Erscheint 4 Ausgaben pro Jahr
ISSN Druckformat: 0731-8898
ISSN Online: 2162-6537
IF:
2.4
5-Year IF:
2.8
Immediacy Index:
0.5
Eigenfactor:
0.00049
JCI:
0.59
SJR:
0.429
SNIP:
0.507
CiteScore™::
3.9
H-Index:
49
Indexed in
D-Pinitol Protects Against Carbon Tetrachloride−Induced Hepatotoxicity in Rats
Get access
ABSTRAKT
The aim of the study was to evaluate the protective activity of D-Pinitol against carbon tetrachloride (CCl4)−induced hepatotoxicity in rats. The animals were divided into six groups, with each group consisting of six animals. Group I animals served as normal controls and received olive oil vehicle (1.0 ml/kg body weight intraperitoneally). Group II rats served as CCl4 controls, which received 30% CCl4 suspended in olive oil (3.0 ml/kg body weight intraperitoneally) twice a week for 4 weeks. Group III rats were treated with 30% CCl4 suspended in olive oil (3.0 ml/kg body weight intraperitoneally) twice a week for 4 weeks, followed by D-Pinitol (100mg/kg body weight) given for 28 days intragastrically. Group IV rats received D-Pinitol alone at a concentration of 100 mg/kg body weight for 28 days intragastrically. At the end of the experimental period, serum marker enzymes and lipid peroxidation (LPO) levels were significantly increased in group II animals. On the other hand, D-Pinitol treatment significantly decreased marker enzymes and LPO levels and increased the antioxidant level. CYP expression was also investigated. Therefore, the present study revealed that D-Pinitol acts as a protective agent by decreasing metabolic activation of xenobiotics through its antioxidant nature.
-
Tang Deping, Wang Fang, Tang Jinzhou, Mao Aihong, Liao Shiqi, Wang Qin, Dicranostiga leptopodu (Maxim.) Fedde extracts attenuated CCl4-induced acute liver damage in mice through increasing anti-oxidative enzyme activity to improve mitochondrial function, Biomedicine & Pharmacotherapy, 85, 2017. Crossref
-
Han Jichun, Wang Dong, Li Defang, Chen Xiaoyu, Wang Bo, Wang Fenghua, Liu Xiaona, Shang Jing, Zheng Qiusheng, Licochalcone E protects against carbon tetrachloride-induced liver toxicity by activating peroxisome proliferator-activated receptor gamma, Molecular Medicine Reports, 16, 4, 2017. Crossref
-
Rahaman Md. Shiblur, Akter Mahmuda, Rahman Md. Mostafizur, Sikder Md. Tajuddin, Hosokawa Toshiyuki, Saito Takeshi, Kurasaki Masaaki, Investigating the protective actions of D-pinitol against arsenic-induced toxicity in PC12 cells and the underlying mechanism, Environmental Toxicology and Pharmacology, 74, 2020. Crossref
-
Sánchez-Hidalgo Marina, León-González Antonio J., Gálvez-Peralta Marina, González-Mauraza Nuria H., Martin-Cordero Carmen, d-Pinitol: a cyclitol with versatile biological and pharmacological activities, Phytochemistry Reviews, 20, 1, 2021. Crossref
-
Pandi Anandakumar, Sattu Kamaraj, Kalappan Vanitha M., Lal Vanita, Varikasuvu Seshadri R., Ganguly Anirban, Prasad Jitender, Pharmacological effects of D‐Pinitol – A comprehensive review , Journal of Food Biochemistry, 2022. Crossref
-
Bello Morenikejimi, Jiddah-kazeem Bidemi, Fatoki Toluwase Hezekiah, Ibukun Emmanuel Oluwafemi, Akinmoladun Afolabi Clement, Antioxidant property of Eucalyptus globulus Labill. Extracts and inhibitory activities on carbohydrate metabolizing enzymes related to type-2 diabetes, Biocatalysis and Agricultural Biotechnology, 36, 2021. Crossref
-
Azab Abdullatif, D-Pinitol—Active Natural Product from Carob with Notable Insulin Regulation, Nutrients, 14, 7, 2022. Crossref