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Forum on Immunopathological Diseases and Therapeutics
SJR: 0.164 SNIP: 0.041 CiteScore™: 0.18

ISSN Druckformat: 2151-8017
ISSN Online: 2151-8025

Archives: Volume 1, 2010 to Volume 7, 2016

Forum on Immunopathological Diseases and Therapeutics

DOI: 10.1615/ForumImmunDisTher.2015014095
pages 223-232

Targeting PGE2 Signaling in Tumor Progression and Angiogenesis

Sandra Donnini
Department of Life Sciences, University of Siena, Siena, Italy
Federica Finetti
Department of Life Sciences, Via Aldo Moro, 2, University of Siena, 53100-Siena, Italy
Erika Terzuoli
Department of Life Sciences, Via Aldo Moro, 2, University of Siena, 53100-Siena, Italy
Lorenzo Bazzani
Department of Life Sciences, University of Siena, Siena, Italy
Marina Ziche
Department of Life Sciences, University of Siena, Siena, Italy

ABSTRAKT

Inflammatory milieu is associated with cancer progression and angiogenesis in different types of tumors, such as gastrointestinal, breast, prostate, and head and neck cancers. Among the inflammatory pathways, numerous evidence indicates that the cyclooxygenase-2/microsomal prostaglandin E synthase-1/prostaglandin E2/E Prostaglandin type receptor (COX-2/mPGES-1/PGE2/EPs) signaling supports epithelial tumor aggressiveness promoting cell growth, epithelial-mesenchymal transition (EMT), and sternness. Further, PGE2 modulates pro-oncogenic and pro-angiogenic pathways such as EGFR and FGFR-1. In this review, we discuss the role of PGE2 and its network of partner proteins in tumor progression and angiogenesis. We also discuss major COX-2/mPGES-1 and EPs therapeutic advances that have been made over the past few years in targeting tumorigenesis and angiogenesis.

SCHLÜSSELWÖRTER: Angiogenesis, inflammation, mPGES-1, PGE2, RTK

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