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Journal of Long-Term Effects of Medical Implants

Erscheint 4 Ausgaben pro Jahr

ISSN Druckformat: 1050-6934

ISSN Online: 1940-4379

SJR: 0.184 SNIP: 0.485 CiteScore™:: 1.1 H-Index: 39

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Surfactant Induced Glistenings: Surface Active Ingredients in Ophthalmic Solutions May Enhance Water Entry into the Voids of Implanted Acrylic Intraocular Lenses

Volumen 16, Ausgabe 6, 2006, pp. 451-457
DOI: 10.1615/JLongTermEffMedImplants.v16.i6.50
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ABSTRAKT

Purpose: To investigate the light scattering properties of acrylic intraocular lenses (IOLs) placed in eyes treated with diclofenac sodium (Diclod®, Wakamoto, Japan) and betamethasone phosphate (Rinderon®, Shionogi, Japan) ophthalmic solutions. Methods: The light scattering properties of IOLs (MA30BA, Alcon laboratories) placed in 32 eyes treated with Diclod® and 31 treated with Rinderon® were evaluated 3 years after implantation using Scheimpflug photography. Results: The averaged intensity of glistenings was 9.0 CCT (computer compatible tapes) in the Diclod® test group and 4.2 CCT in the Rinderon® test group (p = 0.002). The intensity of surface light scattering for the Diclod® and Rinderon® test groups was 24.0 CCT and 26.9 CCT, respectively (p = 0.081). Conclusion: The Diclod® test group had a greater number of glistenings than the Rinderon® test group. Both drugs have similar anti-inflammatory properties and Diclod®, unlike Rinderon®, also contains the surfactant polysorbate. We proposed that the presence of surfactant, or other ingredient, in commercially available eyedrops may enhance the development of glistenings.

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