Abo Bibliothek: Guest
Journal of Long-Term Effects of Medical Implants

Erscheint 4 Ausgaben pro Jahr

ISSN Druckformat: 1050-6934

ISSN Online: 1940-4379

SJR: 0.184 SNIP: 0.485 CiteScore™:: 1.1 H-Index: 39

Indexed in

Physiologically Based Pharmacokinetic Modeling of the Disposition of Octamethylcyclotetrasiloxane (D4) Migration from Implants in Humans

Volumen 18, Ausgabe 2, 2008, pp. 133-144
DOI: 10.1615/JLongTermEffMedImplants.v18.i2.20
Get accessGet access

ABSTRAKT

A physiologically based pharmacokinetic model was developed to describe the silicone constituent octamethylcyclotetrasiloxane (D4) and its migration from intact or ruptured silicone gel-filled breast implants into surrounding tissues. D4 is a representative low-molecular weight constituent of silicone gel that is soluble enough in biological fluids to migrate from the implant and into surrounding tissues. The simulations were based on a representative young adult (premenopausal) woman and a mature (postmenopausal) woman using worst-case exposure conditions (i.e., complete rupture of the largest implant available, maximum levels of D4 in silicone, equal solubility of D4 in breast tissue and gel, and a range of breast tissue fat contents). The results indicate that D4 is cleared primarily by exhalation with highest concentrations achieved briefly in breast tissues of a representative postmenopausal woman. Maximum D4 levels in breast tissues for this scenario were estimated to be approximately 750 ppb with over 90% cleared in about 20 days. Thus, it is unlikely that D4 would be detected in any tissue within a few weeks of receiving an implant, even if immediately ruptured, under the assumptions used in this model.

SCHLÜSSELWÖRTER: D4, implants, PBPK, migration, silicone.
REFERENZIERT VON
  1. McMullin Tami S., Yang Yuching, Campbell Jerry, Clewell Harvey J., Plotzke Kathy, Andersen Melvin E., Development of an integrated multi-species and multi-dose route PBPK model for volatile methyl siloxanes – D4 and D5, Regulatory Toxicology and Pharmacology, 74, 2016. Crossref

  2. Xu Shihe, Kozerski Gary, Mackay Donald, Critical Review and Interpretation of Environmental Data for Volatile Methylsiloxanes: Partition Properties, Environmental Science & Technology, 48, 20, 2014. Crossref

577 Artikelansichten 14 Artikel-Downloads Metriken
577 ANSICHTEN 14 HERUNTERLADEN 2 Crossref ZITATE Google
Scholar
ZITATE

Artikel mit ähnlichem Inhalt:

Evaluation of the Effects of a Nonthermal Atmospheric Pressure Plasma Jet on the Prevention of Enamel Demineralization during Fixed Bracket Treatment Plasma Medicine, Vol.12, 2022, issue 2
Amir Falahat, Ali Reza Saidi, Samira Derakhshan, Seyedeh Fatemeh Peyro Mousavi, Hosniye zia edini, Mohammad Hossein Sobhani Poor, Shekoofeh Shaykhian, Ali Eskandarizadeh, Alireza Ganjovi
In Vivo Toxicity of the Culturable Marine Cyanobacterium Geitlerinema pseudacutissimum CNP 1019 Extract on Male Swiss Albino Mice (Mus musculus) Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 2
Veerabadhran Maruthanayagam, Manivel Nagarajan, Sundararaman Muthuraman
Evaluation of Microbial Leakage at Implant Abutment Interfact for Different Implant Systems: An In Vitro Study Journal of Long-Term Effects of Medical Implants, Vol.32, 2022, issue 2
R. Kushali, P. Jessy, Subhabrata Maiti, Smiline A. S. Girija
Efficacy and Safety of a Percutaneous Tenotomy System for Debridement of Tendinopathic Tissues Journal of Long-Term Effects of Medical Implants, Vol.28, 2018, issue 3
Daniel A. Grande, Andrew K. Wong, Timothy F. Reed, Pooja N. Swami, Adam Bitterman
Prospective Evaluation of Bone Remodeling in Full-Arch Rehabilitations with Morse Taper Implants: A Case Series Study with One-Year Follow-Up Journal of Long-Term Effects of Medical Implants, Vol.32, 2022, issue 3
Carolina Accorsi Cartelli, Sergio Rocha Bernardes, Larissa Carvalho Trojan, Marcos Boaventura de Moura, Geninho Thomé, Ángel José Sánchez Reyes

Zukünftige Artikel

Transfer of guided emergence profile developed using customized provisional implant restoration and cementation using an abutment replica technique- A case report. Vinay Sivaswamy, Balaji Anand S D, Jacob Mathew Philip, C J Venkatakrishnan, Narasimman M, Helen Mary Abraham, Pavithra B Marijuana use is Associated with Increased Rates of Hip Dislocation and Lower Insurance Reimbursement among THA Recipients Andrew Recker, Chukwuweike Gwam, Erin Kelly, Scott Douglas, Johannes Plate Surface modification of Mg alloy AZ91D using nanopowder mixed EDM for Biodegradable Implant Alok Kumar, Abhishek Singh The history of orthopedics in the long term: from general medicine to medical specialties Pavlos Altsitzioglou, Ioannis Zafeiris, Fotini Soucacos, Pantelis Limneos, Eleftheria Souliotis, Evanthia Mitsiokapa, Theodosis Saranteas, Andreas Mavrogenis COMPARISON OF ROUGHNESS, WETTABILITY AND SCANNING ELECTRON MICROSCOPY FEATURES BETWEEN SANDBLASTED ACID-ETCHED AND OXIDIZED TITANIUM DENTAL IMPLANTS Kshitiz Chhabra, Arvina Rajasekar CORRELATION BETWEEN PRIMARY STABILITY OF DENTAL IMPLANTS AND BONE DENSITY: A RETROSPECTIVE ANALYSIS Padmaja S, Arvina Rajasekar C-Reactive Protein and Erythrocyte Sedimentation Rates after total and unicompartmental knee arthroplasty - less implant equals quicker normalization Kasım Kılıçarslan, Ömer Faruk Naldöven, Enejd Veizi, Şahan Güven, Şahin Çepni, Ahmet Fırat COMPLICATIONS FOLLOWING SHORT FEMORAL NAIL FIXATION FOR INTETROCHANTERIC HIP FRACTURES. A RETROSPECTIVE STUDY Anastasia Vasilopoulou, Antonios Trichonas, Konstantinos Palaiologos, Emmanouel Antonogiannakis, Christos Nikakis, Stavros Angelis, Spyridon Maris, Christos Grekas , Efthimios Karadimas, Alexandros Apostolopoulos FEA: Connector Designs and Pontic Stress Distribution of Fixed Partial Denture Implant-Supported Metal Framework Saja Muhsin, Enas Mohammed, Khalid Bander Design and Frequency Stability Analysis of an Adaptive Neuro-Fuzzy Inference System based Artificial Pacemaker Controller in MATLAB Nader Jafarnia Dabanloo, Asghar Dabiriaghdam, Fereidoon Nooshirvan Rahatabad, Keivan Maghooli Complications following intraosseous injections of calcium phosphate bone cement in Subchondroplasty. Christos Zachariadis, Helen Leligou, Stauros Kourkoulis, Evaggelos Magnisalis, Panayiotis Papagelopoulos, Olga Savvidou The Impact of Patient Characteristics on Outcomes of Surgically Managed Vertebral Osteomyelitis in the United States: Insights from a National Database Study Jennifer Kurowicki, Stuart Changoor, Daniel Coban, Neil Patel, Kumar Sinha, Ki Hwang, Arash Emami ASSOCIATION OF AGE, GENDER AND SITE OF IMPLANT PLACEMENT - AN INSTITUTION BASED RETROSPECTIVE STUDY Harini Sri, Nabeel Ahmed, Keerthi Shasanka
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen Preise und Aborichtlinien Begell House Kontakt Language English 中文 Русский Português German French Spain