Erscheint 6 Ausgaben pro Jahr
ISSN Druckformat: 1040-8401
ISSN Online: 2162-6472
Indexed in
Biology of Granzyme M: A Serine Protease with Unique Features
ABSTRAKT
The granule-exocytosis pathway is the major mechanism for cytotoxic lymphocytes to kill tumor cells and virus-infected cells. Cytotoxic granules contain the pore-forming protein perforin and a set of structurally homologues serine proteases called granzymes. Perforin facilitates the entry of granzymes into a target cell, allowing these proteases to initiate distinct cell death routes by cleaving specific intracellular substrates. The family of granzymes consists of multiple members, of which granzyme A and granzyme B have been studied most extensively. Since the cloning of the granzyme M cDNA in the early 1990s, it has remained an "orphan" granzyme for many years and only during the past few years the interest in this protease has increased. Granzyme M appears to be a potent inducer of tumor cell death with morphological hallmarks that are unique among all granzymes. In this review, we summarize the characteristics of granzyme M that are currently known, including its cellular expression, substrate specificity, physiological functions, and inhibitors.
-
van Domselaar Robert, de Poot Stefanie AH, Bovenschen Niels, Proteomic profiling of proteases: tools for granzyme degradomics, Expert Review of Proteomics, 7, 3, 2010. Crossref
-
Zhu Sheng-Ping, Liu Gang, Wu Xiao-Ting, Chen Fu-Xing, Liu Jun-Quan, Zhou Zhong-Hai, Zhang Jian-Fu, Fei Su-Juan, The effect of Phloretin on human γδ T cells killing colon cancer SW-1116 cells, International Immunopharmacology, 15, 1, 2013. Crossref
-
Susanto O., Trapani J. A., Brasacchio D., Controversies in granzyme biology, Tissue Antigens, 80, 6, 2012. Crossref
-
de Poot S A H, Lai K W, van der Wal L, Plasman K, Van Damme P, Porter A C, Gevaert K, Bovenschen N, Granzyme M targets topoisomerase II alpha to trigger cell cycle arrest and caspase-dependent apoptosis, Cell Death & Differentiation, 21, 3, 2014. Crossref
-
Schiffer Sonja, Letzian Soriba, Jost Edgar, Mladenov Radoslav, Hristodorov Dmitrij, Huhn Michael, Fischer Rainer, Barth Stefan, Thepen Theo, Granzyme M as a novel effector molecule for human cytolytic fusion proteins: CD64-specific cytotoxicity of Gm-H22(scFv) against leukemic cells, Cancer Letters, 341, 2, 2013. Crossref
-
de Poot S A H, Bovenschen N, Granzyme M: behind enemy lines, Cell Death & Differentiation, 21, 3, 2014. Crossref
-
Bovenschen Niels, Kummer J. Alain, Orphan granzymes find a home, Immunological Reviews, 235, 1, 2010. Crossref
-
van Domselaar Robert, Bovenschen Niels, Cell death-independent functions of granzymes: hit viruses where it hurts, Reviews in Medical Virology, 21, 5, 2011. Crossref
-
Williams Frances M. K., Scollen Serena, Cao Dandan, Memari Yasin, Hyde Craig L., Zhang Baohong, Sidders Benjamin, Ziemek Daniel, Shi Yujian, Harris Juliette, Harrow Ian, Dougherty Brian, Malarstig Anders, McEwen Robert, Stephens Joel C., Patel Ketan, Menni Cristina, Shin So-Youn, Hodgkiss Dylan, Surdulescu Gabriela, He Wen, Jin Xin, McMahon Stephen B., Soranzo Nicole, John Sally, Wang Jun, Spector Tim D., Leal Suzanne M., Genes Contributing to Pain Sensitivity in the Normal Population: An Exome Sequencing Study, PLoS Genetics, 8, 12, 2012. Crossref
-
de Koning Pieter J. A., Kummer J. Alain, de Poot Stefanie A. H., Quadir Razi, Broekhuizen Roel, McGettrick Anne F., Higgins Wayne J., Devreese Bart, Worrall D. Margaret, Bovenschen Niels, Buckle Ashley M., Intracellular Serine Protease Inhibitor SERPINB4 Inhibits Granzyme M-Induced Cell Death, PLoS ONE, 6, 8, 2011. Crossref
-
Wang Li-Feng, Wang Fang, Li Jun-Tang, Wen Wei-Hong, Zhao Jing, Jia Lin-Tao, Meng Yan-Ling, Cao Yun-Xin, Yao Li-Bo, Chen Si-Yi, Xu Yan-Ming, Yang An-Gang, Gallyas Ferenc, Ectopically Expressed Perforin-1 Is Proapoptotic in Tumor Cell Lines by Increasing Caspase-3 Activity and the Nuclear Translocation of Cytochrome c, PLoS ONE, 7, 7, 2012. Crossref
-
Patel Shyam A., Meyer Justin R., Greco Steven J., Corcoran Kelly E., Bryan Margarette, Rameshwar Pranela, Mesenchymal Stem Cells Protect Breast Cancer Cells through Regulatory T Cells: Role of Mesenchymal Stem Cell-Derived TGF-β, The Journal of Immunology, 184, 10, 2010. Crossref
-
Yang Hyunwon, Youm Yun-Hee, Vandanmagsar Bolormaa, Ravussin Anthony, Gimble Jeffrey M., Greenway Frank, Stephens Jacqueline M., Mynatt Randall L., Dixit Vishwa Deep, Obesity Increases the Production of Proinflammatory Mediators from Adipose Tissue T Cells and Compromises TCR Repertoire Diversity: Implications for Systemic Inflammation and Insulin Resistance, The Journal of Immunology, 185, 3, 2010. Crossref
-
van Domselaar Robert, Philippen Leonne E., Quadir Razi, Wiertz Emmanuel J. H. J., Kummer J. Alain, Bovenschen Niels, Noncytotoxic Inhibition of Cytomegalovirus Replication through NK Cell Protease Granzyme M-Mediated Cleavage of Viral Phosphoprotein 71, The Journal of Immunology, 185, 12, 2010. Crossref
-
de Poot Stefanie A.H., Westgeest Marijn, Hostetter Daniel R., van Damme Petra, Plasman Kim, Demeyer Kimberly, Broekhuizen Roel, Gevaert Kris, Craik Charles S., Bovenschen Niels, Human and mouse granzyme M display divergent and species-specific substrate specificities, Biochemical Journal, 437, 3, 2011. Crossref
-
Caron Jonathan, Ridgley Laura Alice, Bodman-Smith Mark, How to Train Your Dragon: Harnessing Gamma Delta T Cells Antiviral Functions and Trained Immunity in a Pandemic Era, Frontiers in Immunology, 12, 2021. Crossref
-
Ryu Jinhye, Fu Zhirong, Akula Srinivas, Olsson Anna-Karin, Hellman Lars, Extended cleavage specificity of a Chinese alligator granzyme B homologue, a strict Glu-ase in contrast to the mammalian Asp-ases, Developmental & Comparative Immunology, 128, 2022. Crossref