Abo Bibliothek: Guest
Critical Reviews™ in Immunology

Erscheint 6 Ausgaben pro Jahr

ISSN Druckformat: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Clinical and Experimental Sepsis Impairs CD8 T-Cell-Mediated Immunity

Volumen 36, Ausgabe 1, 2016, pp. 57-74
DOI: 10.1615/CritRevImmunol.2016017098
Get accessGet access

ABSTRAKT

Septic patients experience chronic immunosuppression resulting in enhanced susceptibility to infections normally controlled by T cells. Clinical research on septic patients has shown increased apoptosis and reduced total numbers of CD4 and CD8 T cells, suggesting contributing mechanism driving immunosuppression. Experimental models of sepsis, including cecal ligation and puncture, reverse translated this clinical observation to facilitate hypothesis-driven research and allow the use of an array of experimental tools to probe the impact of sepsis on T-cell immunity. In addition to numerical loss, sepsis functionally impairs the antigen-driven proliferative capacity and effector functions of CD4 and CD8 T cells. Sepsis-induced impairments in both the quantity and quality of T cells results in reduced protective capacity and increased susceptibility of mice to new or previously encountered infections. Therefore, the combined efforts of clinical and experimental sepsis research have begun to elucidate the impact of sepsis on T-cell-mediated immunity and potential T-cell-intrinsic and -extrinsic mechanisms driving chronic immunosuppression. Future work will explore the impact of sepsis on the recently appreciated tissue-resident memory (TRM) T cells, which provide robust protection against localized infections, and dendritic cells, which are needed to activate T cells and promote effective T-cell responses.

REFERENZIERT VON
  1. Danahy Derek B., Anthony Scott M., Jensen Isaac J., Hartwig Stacey M., Shan Qiang, Xue Hai-Hui, Harty John T., Griffith Thomas S., Badovinac Vladimir P., Hildeman David A, Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells, PLOS Pathogens, 13, 9, 2017. Crossref

  2. Strother Robert K., Danahy Derek B., Kotov Dmitri I., Kucaba Tamara A., Zacharias Zeb R., Griffith Thomas S., Legge Kevin L., Badovinac Vladimir P., Polymicrobial Sepsis Diminishes Dendritic Cell Numbers and Function Directly Contributing to Impaired Primary CD8 T Cell Responses In Vivo, The Journal of Immunology, 197, 11, 2016. Crossref

  3. Venet Fabienne, Monneret Guillaume, Advances in the understanding and treatment of sepsis-induced immunosuppression, Nature Reviews Nephrology, 14, 2, 2018. Crossref

  4. Kumar V., T cells and their immunometabolism: A novel way to understanding sepsis immunopathogenesis and future therapeutics, European Journal of Cell Biology, 97, 6, 2018. Crossref

  5. Schlieckau Florian, Schulz Daniela, Fill Malfertheiner Sara, Entleutner Kathrin, Seelbach-Goebel Birgit, Ernst Wolfgang, A novel model to study neonatalEscherichia colisepsis and the effect of treatment on the human immune system using humanized mice, American Journal of Reproductive Immunology, 80, 1, 2018. Crossref

  6. Abdo Joe, Cornell David L., Mittal Sumeet K., Agrawal Devendra K., Immunotherapy Plus Cryotherapy: Potential Augmented Abscopal Effect for Advanced Cancers, Frontiers in Oncology, 8, 2018. Crossref

  7. Luo R.-G., Miao X.-Y., Luo L.-L., Mao B., Yu F.-Y., Xu J.-F., Presence of pldA and exoU in mucoid Pseudomonas aeruginosa is associated with high risk of exacerbations in non–cystic fibrosis bronchiectasis patients, Clinical Microbiology and Infection, 25, 5, 2019. Crossref

  8. Morris Gerwyn, Maes Michael, Berk Michael, Puri Basant K., Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?, Metabolic Brain Disease, 34, 2, 2019. Crossref

  9. Dzhalilova Dzhuliia Sh., Kosyreva Anna M., Diatroptov Mikhail E., Zolotova Natalia A., Tsvetkov Ivan S., Mkhitarov Vladimir A., Makarova Olga V., Khochanskiy Dmitry N., Morphological Characteristics of the Thymus and Spleen and the Subpopulation Composition of Lymphocytes in Peripheral Blood during Systemic Inflammatory Response in Male Rats with Different Resistance to Hypoxia, International Journal of Inflammation, 2019, 2019. Crossref

  10. Méndez Raúl, Menéndez Rosario, Amara-Elori Isabel, Feced Laura, Piró Alba, Ramírez Paula, Sempere Amparo, Ortega Alicia, Bermejo-Martín Jesús F., Torres Antoni, Lymphopenic community-acquired pneumonia is associated with a dysregulated immune response and increased severity and mortality, Journal of Infection, 78, 6, 2019. Crossref

  11. Danahy Derek B., Kurup Samarchith P., Winborn Christina S., Jensen Isaac J., Harty John T., Griffith Thomas S., Badovinac Vladimir P., Sepsis-Induced State of Immunoparalysis Is Defined by Diminished CD8 T Cell–Mediated Antitumor Immunity, The Journal of Immunology, 203, 3, 2019. Crossref

  12. Danahy Derek B., Jensen Isaac J., Griffith Thomas S., Badovinac Vladimir P., Cutting Edge: Polymicrobial Sepsis Has the Capacity to Reinvigorate Tumor-Infiltrating CD8 T Cells and Prolong Host Survival, The Journal of Immunology, 202, 10, 2019. Crossref

  13. Imlay Hannah, Limaye Ajit P, Current Understanding of Cytomegalovirus Reactivation in Critical Illness, The Journal of Infectious Diseases, 221, Supplement_1, 2020. Crossref

  14. Martin Matthew D., Badovinac Vladimir P., Griffith Thomas S., CD4 T Cell Responses and the Sepsis-Induced Immunoparalysis State, Frontiers in Immunology, 11, 2020. Crossref

  15. Sjaastad Frances V., Kucaba Tamara A., Dileepan Thamotharampillai, Swanson Whitney, Dail Cody, Cabrera-Perez Javier, Murphy Katherine A., Badovinac Vladimir P., Griffith Thomas S., Polymicrobial Sepsis Impairs Antigen-Specific Memory CD4 T Cell-Mediated Immunity, Frontiers in Immunology, 11, 2020. Crossref

  16. Sjaastad Frances V., Jensen Isaac J., Berton Roger R., Badovinac Vladimir P., Griffith Thomas S., Inducing Experimental Polymicrobial Sepsis by Cecal Ligation and Puncture, Current Protocols in Immunology, 131, 1, 2020. Crossref

  17. Zhao Dongyang, Li Zhe, Liu Xiandong, Liu Na, Bao Xiaowei, Sun Hong, Meng Qinshu, Ren Huijuan, Bai Jianwen, Zhou Xiaohui, Tang Lunxian, Lymphocyte expression of EZH2 is associated with mortality and secondary infectious complications in sepsis, International Immunopharmacology, 89, 2020. Crossref

  18. Jensen Isaac J., McGonagill Patrick W., Butler Noah S., Harty John T., Griffith Thomas S., Badovinac Vladimir P., NK Cell–Derived IL-10 Supports Host Survival during Sepsis, The Journal of Immunology, 206, 6, 2021. Crossref

  19. Guo Li, Shen Sikui, Rowley Jesse W., Tolley Neal D., Jia Wenwen, Manne Bhanu Kanth, McComas Kyra N., Bolingbroke Ben, Kosaka Yasuhiro, Krauel Krystin, Denorme Frederik, Jacob Shancy P., Eustes Alicia S., Campbell Robert A., Middleton Elizabeth A., He Xiao, Brown Samuel M., Morrell Craig N., Weyrich Andrew S., Rondina Matthew T., Platelet MHC class I mediates CD8+ T-cell suppression during sepsis, Blood, 138, 5, 2021. Crossref

  20. Desai Pritesh, Janova Hana, White James P., Reynoso Glennys V., Hickman Heather D., Baldridge Megan T., Urban Joseph F., Stappenbeck Thaddeus S., Thackray Larissa B., Diamond Michael S., Enteric helminth coinfection enhances host susceptibility to neurotropic flaviviruses via a tuft cell-IL-4 receptor signaling axis, Cell, 184, 5, 2021. Crossref

  21. Yao Ren-Qi, Ren Chao, Zheng Li-Yu, Xia Zhao-Fan, Yao Yong-Ming, Advances in Immune Monitoring Approaches for Sepsis-Induced Immunosuppression, Frontiers in Immunology, 13, 2022. Crossref

  22. Torres Lisa K., Pickkers Peter, van der Poll Tom, Sepsis-Induced Immunosuppression, Annual Review of Physiology, 84, 1, 2022. Crossref

  23. Voiriot Guillaume, Oualha Mehdi, Pierre Alexandre, Salmon-Gandonnière Charlotte, Gaudet Alexandre, Jouan Youenn, Kallel Hatem, Radermacher Peter, Vodovar Dominique, Sarton Benjamine, Stiel Laure, Bréchot Nicolas, Préau Sébastien, Joffre Jérémie, Chronic critical illness and post-intensive care syndrome: from pathophysiology to clinical challenges, Annals of Intensive Care, 12, 1, 2022. Crossref

  24. van der Poll Tom, Shankar-Hari Manu, Wiersinga W. Joost, The immunology of sepsis, Immunity, 54, 11, 2021. Crossref

  25. Peng Yizhi, Wang Xiaofan, Yin Sheng, Wang Min, A new indicator: The diagnostic value of CD8+T/B lymphocyte ratio in sepsis progression, International Journal of Immunopathology and Pharmacology, 36, 2022. Crossref

  26. Chen Hongyan, Zhang Xiaoting, Su Hao, Zeng Judeng, Chan Hung, Li Qing, Liu Xiaodong, Zhang Lin, Wu William Ka Kei, Chan Matthew Tak Vai, Chen Huarong, Immune dysregulation and RNA N6 ‐methyladenosine modification in sepsis , WIREs RNA, 2022. Crossref

  27. Li Jingru, Sun Guihu, Ma Haocheng, Wu Xinyu, Li Chaozhong, Ding Peng, Lu Si, Li Yanyan, Yang Ping, Li Chaguo, Yang Jun, Peng Yunzhu, Meng Zhaohui, Wang Luqiao, Identification of immune-related hub genes and miRNA-mRNA pairs involved in immune infiltration in human septic cardiomyopathy by bioinformatics analysis, Frontiers in Cardiovascular Medicine, 9, 2022. Crossref

  28. Luperto Marta, Zafrani Lara, T cell dysregulation in inflammatory diseases in ICU, Intensive Care Medicine Experimental, 10, 1, 2022. Crossref

  29. Xu Lei, Wei Chuan, Chen Ying, Wu Yue, Shou Xiaoli, Chen Wenjie, Lu Di, Sun Haoran, Li Wei, Yu Beibei, Wang Xiaowei, Zhang Xiaojun, Yu Yanxiong, Lei Zhigang, Tang Rui, Zhu Jifeng, Li Yalin, Lu Linrong, Zhou Hong, Zhou Sha, Su Chuan, Chen Xiaojun, IL-33 induces thymic involution-associated naive T cell aging and impairs host control of severe infection, Nature Communications, 13, 1, 2022. Crossref

  30. Yan Lei, Chen Yumei, Han Yi, Tong Chaoyang, Role of CD8+ T cell exhaustion in the progression and prognosis of acute respiratory distress syndrome induced by sepsis: a prospective observational study, BMC Emergency Medicine, 22, 1, 2022. Crossref

Zukünftige Artikel

Identification of a novel five-gene prognostic model for laryngeal cancer associated with mitophagy using integrated bioinformatics analysis and experimental verification Dong Song, Lun Dong, Mei Wang, Xiaoping Gao Function of steroid receptor coactivators (SRCs) in T cells and cancers: Implications for cancer immunotherapy Wencan Zhang, Xu Cao, Hongmin Wu, Xiancai Zhong, Yun Shi, Zuoming Sun Electroacupuncture Alleviates Ischemic Stroke by Activating the mTOR/SREBP1 Pathway Jiawang Lang, Jianchang Luo, Luodan Wang, Wenbin Xu, Jie Jia, Zhipeng Zhao, Boxu Lang KIAA1429 induces the m6A modification of LINC01106 to enhance the malignancy of lung adenocarcinoma cell via JAK/STAT3 pathway Di Xu, Ziming Wang, Fajiu Li Effect of p-estrogen receptor at serine on its function and breast growth Yuan Liang, Junhui Qin, Tiancheng Ma, Tong Yang, Zhenyu Ke, Ruian Wang Mechanistic Insights into Tanshinone IIA in the Amelioration of Post-Thyroidectomy Hypoparathyroidism Xiaoyu Qian, Lin Li, Liang Chen, Chao Shen, Jian Tang MiRNA let-7d-5p alleviates inflammatory responses by targeting Map3k1 and inactivating ERK/p38 MAPK signaling in microglia Fan Fang, Cheng Chen Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro Kawaljit Kaur, Anahid Jewett The Current and Future States of Natural Killer Cell-Based Immunotherapy in Hepatocellular Carcinoma Tu Nguyen, Po-Chun Chen, Janet Pham, Kawaljit Kaur, Steven Raman, Anahid Jewett, Jason Chiang Phillygenin alleviated arthritis through the inhibition of NLRP3 inflammasome and Ferroptosis by AMPK Jianghui Wang, Shufang Ni, Kai Zheng, Yan Zhao, peihong zhang, Hong Chang The value of systemic immune-inflammation index and T cell subsets in the severity and prognosis of sepsis Hao Zhou Efficacy and Nuances of Precision Molecular Engineering for Hodgkin's Disease to a Gene Therapeutic Approach Muhammad Imran Qadir, Bilal Ahmed, Nadir Hussain Serum interleukin 6 and ferritin levels are the independent risk factors for pneumonia in elderly patients Hao Yuan, Jing Tian, Lu Wen Exploration of diagnostic markers associated with inflammation in chronic kidney disease (CKD) based on WGCNA and machine learning Qianjia Wu, Yang Yang, Chongze Lin Clinical significance of serum CTRP3 level in the prediction of cardiac dysfunction and intestinal mucosal barrier dysfunction in patients with severe acute pancreatitis Qiang Shao, Lin Sun The protective effect and mechanism of mild hypothermia on pig lung injury after cardiopulmonary resuscitation Jinlin Ren, Fangfang Zhu, Dongdong Sang, Mulin Cong, Shujuan Jiang Exploring mechanism of Zilongjin in treating lung adenocarcinoma based on network pharmacology combined with experimental verification Kang Zhang, Xiaoqun Chen Gastric Cancer Immune Subtypes and Prognostic Modeling: Insights from Aging-Related Genes Analysis Jian Shen, Minzhe Li Effects of different doses of dexmedetomidine on the prevention of postoperative sleep disturbance and serum neurotransmitter level in patients under general anesthesia Huifei Lu, Fei He, Ying Huang, Zhongliang Wei Identification of key ubiquitination-related genes and their associated with immune infiltration in osteoarthritis based on mRNA-miRNA network Dalu Yuan, Hailiang Shen, Lina Bai, Menglin Li, Qiujie Ye Diagnostic and Prognostic value of peripheral neutrophil CD64 index in elderly patients with community-acquired pneumonia Yan Li, Jing Zhang, Suhang Wang, Jie Cao Identification of Metabolism-Related Prognostic Biomarkers and Immune Features of Head and Neck Squamous Cell Carcinoma Rongjin Zhou, Junguo Wang Downregulation of miR-503-5p promotes the development of pancreatic cancer via targeting cyclin E2 Fei Li, Ying-pei Ling, Pan Wang, Shi-cheng Gu, Hao Jiang, Jie Zhu
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen Preise und Aborichtlinien Begell House Kontakt Language English 中文 Русский Português German French Spain