Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Critical Reviews™ in Immunology
Impact-faktor: 1.404 5-jähriger Impact-Faktor: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Druckformat: 1040-8401
ISSN Online: 2162-6472

Volumes:
Volumen 40, 2020 Volumen 39, 2019 Volumen 38, 2018 Volumen 37, 2017 Volumen 36, 2016 Volumen 35, 2015 Volumen 34, 2014 Volumen 33, 2013 Volumen 32, 2012 Volumen 31, 2011 Volumen 30, 2010 Volumen 29, 2009 Volumen 28, 2008 Volumen 27, 2007 Volumen 26, 2006 Volumen 25, 2005 Volumen 24, 2004 Volumen 23, 2003 Volumen 22, 2002 Volumen 21, 2001 Volumen 20, 2000 Volumen 19, 1999 Volumen 18, 1998 Volumen 17, 1997 Volumen 16, 1996 Volumen 15, 1995 Volumen 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v29.i2.10
pages 87-109

Integrin Function in T-Cell Homing to Lymphoid and Nonlymphoid Sites: Getting There and Staying There

Christopher C. DeNucci
Department of Laboratory Medicine and Pathology, Center for Immunology, Masonic Cancer Center, University of Minnesota Medical School, Minneapolis, MN
Jason S. Mitchell
Department of Laboratory Medicine and Pathology, Center for Immunology, Masonic Cancer Center, University of Minnesota Medical School, Minneapolis, MN
Yoji Shimizu
Department of Laboratory Medicine and Pathology, Center for Immunology, Masonic Cancer Center, University of Minnesota Medical School, Minneapolis, MN

ABSTRAKT

The continuous recirculation of naive T cells and their subsequent migration to tissue following activation is crucial for maintaining protective immunity against invading pathogens. The preferential targeting of effector and memory T cells to tissue is instructed during priming and mediated by cell surface expressed adhesion receptors such as integrins. Integrins are involved in nearly all aspects of T-cell life, including naive T-cell circulation, activation, and finally effector T-cell trafficking and localization. Recent research has revealed that microenvironmental factors present during T-cell priming result in the specific regulation of adhesion/integrin and chemokine receptor expression. Once antigen-experienced T cells enter tissue, further changes in integrin expression may occur that are critical for T-cell localization, retention, effector function, and survival. This review discusses the function of integrin expression on T cells and the multiple roles integrins play on naive T cells and in directing effector T-cell trafficking to nonlymphoid sites in order to maintain protective adaptive immunity at body barriers.


Articles with similar content:

Expression of T Lymphocyte Adhesion Molecules: Regulation During Antigen-Induced T Cell Activation and Differentiation
Critical Reviews™ in Immunology, Vol.18, 1998, issue 3
Morris O. Dailey
Peripheral CD8 T-Cell Responses to Apoptotic Cell Proteins and Peptides
Critical Reviews™ in Immunology, Vol.27, 2007, issue 4
Yu Feng Peng, Keith B. Elkon
Lymphokine-Dependent Proliferation of T-Lymphoid Cells: Regulated Responsiveness and Role In Vivo
Critical Reviews™ in Immunology, Vol.21, 2001, issue 6
Ana L. Mora, Linda M. Stephenson, Mark Boothby
Mechanism of Activation-Induced Cell Death of T Cells and Regulation of FasL Expression
Critical Reviews™ in Immunology, Vol.34, 2014, issue 4
Akiko Yamada, Yasusei Kudo, Yoshio Hayashi, Naozumi Ishimaru, Rieko Arakaki
Regulatory T-cell Trafficking: From Thymic Development to Tumor-Induced Immune Suppression
Critical Reviews™ in Immunology, Vol.30, 2010, issue 5
Adam Mailloux, M. Rita I. Young