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Critical Reviews™ in Immunology

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ISSN Druckformat: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Exosome Release by Primary B Cells

Volumen 29, Ausgabe 3, 2009, pp. 203-217
DOI: 10.1615/CritRevImmunol.v29.i3.20
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ABSTRAKT

Exosomes are subcellular nanoparticles derived from the endosomal pathway. It is now becoming clear that a potential major in vivo source of exosomes is the B cell. Although it has been widely assumed that exosome release is a constitutive activity of most cell types, recent work has emphasized the role of cellular activation in the release of exosomes from primary cells. Like other lymphocytes, B cells undergo extensive cellular physiologic changes during the process of differentiation into effector cells. One newly identified feature of this process is exosome synthesis, which is initiated following the receipt of activation signals, particularly T-cell "help" via CD40 and IL-4 signaling. B-cell-derived exosomes contain immunoglobulin, which traffics antigen bound by the surface B-cell receptor (BCR) into the endosomal/exosomal pathway and finally into the extracellular space. Exosomes have been implicated in viral transmission, cell signaling, and antigen presentation, as well as in the disposal of effete or defective cellular components. However, the possible targets of B-cell-derived exosomes remain unknown. This review focuses on the synthesis and release of exosomes derived from activated and malignant B cells and explores the possible functions of B-cell-derived exosomes in immune function.

SCHLÜSSELWÖRTER: B cells, CD40, IL-4, exosomes
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