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Critical Reviews™ in Immunology

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ISSN Druckformat: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Intracellular Pattern Recognition Receptors and Renal Ischemia

Volumen 31, Ausgabe 4, 2011, pp. 297-306
DOI: 10.1615/CritRevImmunol.v31.i4.20
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ABSTRAKT

Renal ischemia is a common cause of acute kidney injury in hospitalized patients. In certain settings renal ischemia is unavoidable, such as in kidneys harvested for transplantation. The molecular and cellular mechanisms that lead to the syndrome of ischemic renal injury are complicated and involve multiple cell types within the kidney, including renal epithelium and vasculature. Although it has been difficult to define pharmacologic targets for AKI, emerging information about a newly discovered host defense system is providing hope for novel pharmacologic targets to prevent and treat AKI. Molecular initiators of damage associated with hypoxia involve a phylogenically conserved host defense system called the innate immune system. Data point to an essential role for receptors of the innate immune system, particularly the membrane-bound Toll-like receptors and the intracellular nucleotide-binding oligomerization domain-like receptors. These receptors have been identified in human and rodent kidneys, and many investigators have shown that their deletion protects from experimental ischemia/reperfusion injury (a model for ischemic acute kidney injury). This review details current information about the innate immune system and the ischemic kidney with a focus on the emerging role of intracellular innate immune receptors.

REFERENZIERT VON
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