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ISSN Druckformat: 1040-8401
ISSN Online: 2162-6472
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p120-CATENIN: A NOVEL REGULATOR OF INNATE IMMUNITY AND INFLAMMATION
ABSTRAKT
p120-Catenin is the prototypic member of a subfamily of armadillo repeat domain proteins. Like its structural homologues, β- and γ-catenin, p120-catenin is an essential component of adherens junctions in endothelial cells and other polarized adherent cells. p120-Catenin binds directly to the cytoplasmic domain of cadherin and contributes to the regulation of cell−cell junctional integrity. Studies have demonstrated that p120-catenin plays important roles in cell−cell adhesion, embryonic development, cell proliferation and polarity, tumor cell migration, and cancer progression. However, recent insights have generated an entirely new perspective, suggesting that p120-catenin is implicated in the anti-inflammatory responses in the absence and presence of infection. This review summarizes the present knowledge and recent progress toward elucidating the novel role of p120-catenin in the regulation of innate immunity and inflammation.
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Ma Jiayin, Zhao Dan, Wu Yaqin, Xu Chun, Zhang Fuqiang, Cyclic stretch induced gene expression of extracellular matrix and adhesion molecules in human periodontal ligament cells, Archives of Oral Biology, 60, 3, 2015. Crossref
-
Kobielak Agnieszka, Boddupally Keerthi, Junctions and Inflammation in the Skin, Cell Communication & Adhesion, 21, 3, 2014. Crossref
-
Mehta Shameer, Nijhuis Anke, Kumagai Tomoko, Lindsay James, Silver Andrew, Defects in the adherens junction complex (E-cadherin/ β-catenin) in inflammatory bowel disease, Cell and Tissue Research, 360, 3, 2015. Crossref
-
Hendley Audrey M., Provost Elayne, Bailey Jennifer M., Wang Yue J., Cleveland Megan H., Blake Danielle, Bittman Ross W., Roeser Jeffrey C., Maitra Anirban, Reynolds Albert B., Leach Steven D., p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas, Developmental Biology, 399, 1, 2015. Crossref
-
Hong Ji Yeon, Oh Il-Hoan, McCrea Pierre D., Phosphorylation and isoform use in p120-catenin during development and tumorigenesis, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1863, 1, 2016. Crossref
-
Pierre Christina C., Longo Joseph, Mavor Meaghan, Milosavljevic Snezana B., Chaudhary Roopali, Gilbreath Ebony, Yates Clayton, Daniel Juliet M., Kaiso overexpression promotes intestinal inflammation and potentiates intestinal tumorigenesis in ApcMin/+ mice, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1852, 9, 2015. Crossref
-
Chignalia Andreia Z., Vogel Stephen M., Reynolds Albert B., Mehta Dolly, Dull Randal O., Minshall Richard D., Malik Asrar B., Liu Yuru, p120-Catenin Expressed in Alveolar Type II Cells Is Essential for the Regulation of Lung Innate Immune Response, The American Journal of Pathology, 185, 5, 2015. Crossref
-
Hang Ta-Chun, Tedford Nathan C., Reddy Raven J., Rimchala Tharathorn, Wells Alan, White Forest M., Kamm Roger D., Lauffenburger Douglas A., Vascular Endothelial Growth Factor (VEGF) and Platelet (PF-4) Factor 4 Inputs Modulate Human Microvascular Endothelial Signaling in a Three-Dimensional Matrix Migration Context, Molecular & Cellular Proteomics, 12, 12, 2013. Crossref
-
Yang Zhiyong, Sun Dong, Yan Zhibo, Reynolds Albert B., Christman John W., Minshall Richard D., Malik Asrar B., Zhang Yang, Hu Guochang, Differential Role for p120-Catenin in Regulation of TLR4 Signaling in Macrophages, The Journal of Immunology, 193, 4, 2014. Crossref
-
Gu Changping, Dai Chenyang, Sun Yongtao, Liu Mengjie, Wang Yuelan, Wu Xinyi, P120 regulates beta-catenin nuclear translocation through E-cadherin endocytosis in ventilator-induced lung injury, Oncotarget, 7, 51, 2016. Crossref
-
Zhang Honglei, Cui Yong, Zhou Zhiyu, Ding Yan, Nie Hongguang, Alveolar Type 2 Epithelial Cells as Potential Therapeutics for Acute Lung Injury/Acute Respiratory Distress Syndrome, Current Pharmaceutical Design, 25, 46, 2020. Crossref
-
Adil Mir S., Narayanan S. Priya, Somanath Payaningal R., Cell-cell junctions: structure and regulation in physiology and pathology, Tissue Barriers, 9, 1, 2021. Crossref
-
Lin Qun, Fang Xiaolin, Liang Gehao, Luo Qing, Cen Yinghuan, Shi Yu, Jia Shijie, Li Juanmei, Yang Wenqian, Sanders Andrew J., Gong Chang, Jiang Wenguo, Silencing CTNND1 Mediates Triple-Negative Breast Cancer Bone Metastasis via Upregulating CXCR4/CXCL12 Axis and Neutrophils Infiltration in Bone, Cancers, 13, 22, 2021. Crossref
-
Beyrakhova Ksenia, Li Lei, Xu Caishuang, Gagarinova Alla, Cygler Miroslaw, Legionella pneumophila effector Lem4 is a membrane-associated protein tyrosine phosphatase, Journal of Biological Chemistry, 293, 34, 2018. Crossref
-
Kurley Sarah J., Tischler Verena, Bierie Brian, Novitskiy Sergey V., Noske Aurelia, Varga Zsuzsanna, Zürrer-Härdi Ursina, Brandt Simone, Carnahan Robert H., Cook Rebecca S., Muller William J., Richmond Ann, Reynolds Albert B., A Requirement for p120-catenin in the metastasis of invasive ductal breast cancer, Journal of Cell Science, 2020. Crossref
-
Hendley Audrey M., Wang Yue J., Polireddy Kishore, Alsina Janivette, Ahmed Ishrat, Lafaro Kelly J., Zhang Hao, Roy Nilotpal, Savidge Samuel G., Cao Yanna, Hebrok Matthias, Maitra Anirban, Reynolds Albert B., Goggins Michael, Younes Mamoun, Iacobuzio-Donahue Christine A., Leach Steven D., Bailey Jennifer M., p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia, Cancer Research, 76, 11, 2016. Crossref
-
Kulhankova Katarina, Kinney Kyle J., Stach Jessica M., Gourronc Françoise A., Grumbach Isabella M., Klingelhutz Aloysius J., Salgado-Pabón Wilmara, Torres Victor J., The Superantigen Toxic Shock Syndrome Toxin 1 Alters Human Aortic Endothelial Cell Function, Infection and Immunity, 86, 3, 2018. Crossref
-
Li X.-L., Feng Q.-M., Yang H.-N., Ruan J.-W., Kang Y.-F., Yu Z.-E., Liu J.-X., Chen A.-N., Cui Y.-H., Liu Z., Lu X., p120 regulates E-cadherin expression in nasal epithelial cells in chronic rhinosinusitis, Rhinology journal, 2022. Crossref
-
Lessey Lindyann R., Robinson Shaiya C., Chaudhary Roopali, Daniel Juliet M., Adherens junction proteins on the move—From the membrane to the nucleus in intestinal diseases, Frontiers in Cell and Developmental Biology, 10, 2022. Crossref