Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Critical Reviews™ in Immunology
Impact-faktor: 1.404 5-jähriger Impact-Faktor: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Druckformat: 1040-8401
ISSN Online: 2162-6472

Volumes:
Volumen 40, 2020 Volumen 39, 2019 Volumen 38, 2018 Volumen 37, 2017 Volumen 36, 2016 Volumen 35, 2015 Volumen 34, 2014 Volumen 33, 2013 Volumen 32, 2012 Volumen 31, 2011 Volumen 30, 2010 Volumen 29, 2009 Volumen 28, 2008 Volumen 27, 2007 Volumen 26, 2006 Volumen 25, 2005 Volumen 24, 2004 Volumen 23, 2003 Volumen 22, 2002 Volumen 21, 2001 Volumen 20, 2000 Volumen 19, 1999 Volumen 18, 1998 Volumen 17, 1997 Volumen 16, 1996 Volumen 15, 1995 Volumen 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v14.i2.10
pages 89-129

HLA Class I Chromosomal Region, Genes, and Products: Facts and Questions

Philippe Le Bouteiller
Unite INSERM 395, CHU Purpan, BP 3028, 31024 Toulouse, France

ABSTRAKT

Among the various areas of recent investigation in the field of human MHC class I antigens, the following have been selected for discussion in this review: (1) classical HLA class I genes: are they ubiquitously expressed?, what are the special features of their polymorphism?, are HLA-C molecules functional?, (2) non-classical HLA class I gene products: how restricted is their tissue distribution?, do they exhibit a little polymorphism?, what is their function, if any? (3) non-HLA genes recently detected in the HLA class I chromosomal region: are some of them involved in immunological function and development?, (4) other novel coding sequences present, or possibly present, in the region: the hemochromatosis gene, grc region and associated tumor suppressor genes, housekeeping genes, human equivalent of the murine H-2M region and Ped gene; (5) transcriptional regulation: are there cis-regulatory elements, including locus control region(s). located elsewhere than in the promoters? are CpG methylation, gene imprinting, chromatin structure, DNA rearrangement also implicated? what are the transcription factors involved and how do they interact with each other? is there HLA class I locus-, allele-, or isoform-specific regulation? is class I gene expression dysregulated in human tumors? The answers to these questions are crucial for the development of the future directions for research.


Articles with similar content:

HLA Class I Chromosomal Region, Genes, and Products: Facts and Questions
Critical Reviews™ in Immunology, Vol.37, 2017, issue 2-6
Philippe Le Bouteiller
DLK1-MEG3 Imprinted Domain MicroRNAs in Cancer Biology
Critical Reviews™ in Eukaryotic Gene Expression, Vol.22, 2012, issue 1
George Vartholomatos, Evangelos Voulgaris, Leonidas Benetatos
Nuclear snRNA and Nuclear Function (Discovery of 5′ Cap Structures in RNA)
Critical Reviews™ in Eukaryotic Gene Expression, Vol.9, 1999, issue 2
Tae Suk Ro-Choi
The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression
Critical Reviews™ in Eukaryotic Gene Expression, Vol.18, 2008, issue 3
J. Luis Morales, Brett D. Hollingshead, Gary H. Perdew, Timothy V. Beischlag
Genomic Pathology and Cancer Biomarkers: Prostate Cancer
Critical Reviews™ in Oncogenesis, Vol.22, 2017, issue 5-6
Kenneth A. Iczkowski