Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Critical Reviews™ in Immunology
Impact-faktor: 1.404 5-jähriger Impact-Faktor: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Druckformat: 1040-8401
ISSN Online: 2162-6472

Volumen 40, 2020 Volumen 39, 2019 Volumen 38, 2018 Volumen 37, 2017 Volumen 36, 2016 Volumen 35, 2015 Volumen 34, 2014 Volumen 33, 2013 Volumen 32, 2012 Volumen 31, 2011 Volumen 30, 2010 Volumen 29, 2009 Volumen 28, 2008 Volumen 27, 2007 Volumen 26, 2006 Volumen 25, 2005 Volumen 24, 2004 Volumen 23, 2003 Volumen 22, 2002 Volumen 21, 2001 Volumen 20, 2000 Volumen 19, 1999 Volumen 18, 1998 Volumen 17, 1997 Volumen 16, 1996 Volumen 15, 1995 Volumen 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v29.i5.10
pages 369-377

Genital and Oral Mucosal Immune Response Against HIV-1 in Exposed Uninfected Individuals

Klara Hasselrot
Center for Molecular Medicine, Karolinska University Hospital, Department of Medicine, Solna, Unit of Infectious Diseases, Karolinska Institute, Stockholm, Sweden


Epidemiologic reports routinely indicate that the high rate of HIV-1 transmission via mucosal exposure has been relatively stable since the epidemic began. Unfortunately, research on mucosal immune responses to HIV-1 has not been done in proportion to its importance. Most knowledge about immune responses against HIV-1 in humans comes from studies limited to the use of peripheral blood cells and plasma. Consequently, T-cell-based HIV-1 vaccines have long been considered a primary end point of preventive therapeutic strategies. The interest in HIV-1 exposed uninfected individuals has intensified because of the lessons to be learned about a natural immunologic response that promotes opposition to the infection. Such information has useful applications in the clinical setting. This review describes the current status of research on mucosal immune responses to HIV-1 from examining mucosal fluids and tissues of sexually exposed uninfected adults.

Articles with similar content:

Understanding the Role of Innate Immunity in the Response to Intracortical Microelectrodes
Critical Reviews™ in Biomedical Engineering, Vol.46, 2018, issue 4
John K. Hermann, Jeffrey R. Capadona
Antigen-Specific Tolerance in Immunotherapy of Th2-Associated Allergic Diseases
Critical Reviews™ in Immunology, Vol.33, 2013, issue 5
Paul J. Bryce, Charles B. Smarr, Stephen D. Miller
Measles Virus Infection and Vaccination: Potential Role in Chronic Illness and Associated Adverse Events
Critical Reviews™ in Immunology, Vol.24, 2004, issue 2
Vera S. Byers, Ronald C. Kennedy, John J. Marchalonis
Modulation of Innate Immune Responses by Hantaviruses
Critical Reviews™ in Immunology, Vol.30, 2010, issue 6
Andreas Rang
Understanding How Lipopolysaccharide Impacts CD4 T-Cell Immunity
Critical Reviews™ in Immunology, Vol.28, 2008, issue 4
Anthony T. Vella, Jeremy P. McAleer