Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Critical Reviews™ in Immunology
Impact-faktor: 1.352 5-jähriger Impact-Faktor: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Druckformat: 1040-8401
ISSN Online: 2162-6472

Volumes:
Volumen 39, 2019 Volumen 38, 2018 Volumen 37, 2017 Volumen 36, 2016 Volumen 35, 2015 Volumen 34, 2014 Volumen 33, 2013 Volumen 32, 2012 Volumen 31, 2011 Volumen 30, 2010 Volumen 29, 2009 Volumen 28, 2008 Volumen 27, 2007 Volumen 26, 2006 Volumen 25, 2005 Volumen 24, 2004 Volumen 23, 2003 Volumen 22, 2002 Volumen 21, 2001 Volumen 20, 2000 Volumen 19, 1999 Volumen 18, 1998 Volumen 17, 1997 Volumen 16, 1996 Volumen 15, 1995 Volumen 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v27.i6.60
pages 559-572

Comprehensive Insight into Human Aminoacyl-tRNA Synthetases as Autoantigens in Idiopathic Inflammatory Myopathies

Miroslawa Jura
Institute of Bioorganic Chemistry of Polish Academy of Sciences, 60-704 Poznan, Poland; and BioInfoBank Institute, ul. Limanowskiego 24A, 60-744 Poznan, Poland
Leszek Rychlewski
BioInfoBank Institute, ul. Limanowskiego 24A, 60-744 Poznan, Poland
Jan Barciszewski
Institute of Bioorganic Chemistry of Polish Academy of Sciences, 60-704 Poznan, Poland

ABSTRAKT

Autoantibodies against aminoacyl-tRNA synthetases (anti-AARS) belong to the group of the myositis specific autoantibodies (MSAs). Their association with the onset and development of the idiopathic inflammatory myopathies (IIM) implies their participation in the pathogenesis of the diseases. Since the appearing of anti-Jo-1 and other anti-AARSs is related to characteristic immunogenetic and clinical features, they can be considered specific markers in diagnosis and classification of patients affected by IIM. Here, we present an overview of anti-AARSs, their chemoattractant properties, their detection methods, genetic risks, and protective factors.


Articles with similar content:

Immunopathogenesis of the Anti-Synthetase Syndrome
Critical Reviews™ in Immunology, Vol.38, 2018, issue 4
Yurdagül Uzunhan, Baptiste Hervier, Vincent Vieillard, Catherine Gayed, Isabelle Cremer
The Role of the Lkb1/AMPK Pathway in Hematopoietic Stem Cells and Leukemia
Critical Reviews™ in Oncogenesis, Vol.19, 2014, issue 5
Daisuke Nakada, Yusuke Saito
Genome-Wide Association Studies and Infectious Disease
Critical Reviews™ in Immunology, Vol.30, 2010, issue 3
Anne M. Bowcock
Modern Concepts of the Diagnosis and Treatment of Purpura Fulminans
Journal of Environmental Pathology, Toxicology and Oncology, Vol.27, 2008, issue 3
Jill J. Dahlstrom, William B. Long III, Richard Edlich, Catherine L. Cross
Modern Concepts of the Diagnosis and Treatment of Psoriasis
Journal of Environmental Pathology, Toxicology and Oncology, Vol.28, 2009, issue 3
William B. Long III, Carroll M. Brock, Richard Edlich, Allyson L. Fisher, Margot E. Chase, K. Dean Gubler