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Critical Reviews™ in Immunology
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ISSN Druckformat: 1040-8401
ISSN Online: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v27.i6.60
pages 559-572

Comprehensive Insight into Human Aminoacyl-tRNA Synthetases as Autoantigens in Idiopathic Inflammatory Myopathies

Miroslawa Jura
Institute of Bioorganic Chemistry of Polish Academy of Sciences, 60-704 Poznan, Poland; and BioInfoBank Institute, ul. Limanowskiego 24A, 60-744 Poznan, Poland
Leszek Rychlewski
BioInfoBank Institute, ul. Limanowskiego 24A, 60-744 Poznan, Poland
Jan Barciszewski
Institute of Bioorganic Chemistry of Polish Academy of Sciences, 60-704 Poznan, Poland

ABSTRAKT

Autoantibodies against aminoacyl-tRNA synthetases (anti-AARS) belong to the group of the myositis specific autoantibodies (MSAs). Their association with the onset and development of the idiopathic inflammatory myopathies (IIM) implies their participation in the pathogenesis of the diseases. Since the appearing of anti-Jo-1 and other anti-AARSs is related to characteristic immunogenetic and clinical features, they can be considered specific markers in diagnosis and classification of patients affected by IIM. Here, we present an overview of anti-AARSs, their chemoattractant properties, their detection methods, genetic risks, and protective factors.


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