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Critical Reviews™ in Immunology

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ISSN Druckformat: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Fungal Capsular Polysaccharide and T-Cell Suppression: The Hidden Nature of Poor Immunogenicity

Volumen 27, Ausgabe 6, 2007, pp. 547-557
DOI: 10.1615/CritRevImmunol.v27.i6.50
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ABSTRAKT

Many capsular polysaccharide antigens are generally considered to be classic T-cell independent antigens that stimulate humoral response. This response is poor and short lived due to the absence of T-cell involvement. Recent emerging evidence suggests that fungal capsular polysaccharides may negatively affect T-cell response. This effect is indirectly mediated by antigen-presenting cells that sense microbial polysaccharides and manage T-cell response. This review will revisit the role of the cryptococcal capsular polysaccharide as a nonconventional regulator of natural and adaptive immune response, revealing the hidden nature of its poor immunogenicity and novel opportunities for the biomedical exploitation of this nontoxic compound.

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