Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Critical Reviews™ in Immunology
Impact-faktor: 1.404 5-jähriger Impact-Faktor: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Druckformat: 1040-8401
ISSN Online: 2162-6472

Volumes:
Volumen 40, 2020 Volumen 39, 2019 Volumen 38, 2018 Volumen 37, 2017 Volumen 36, 2016 Volumen 35, 2015 Volumen 34, 2014 Volumen 33, 2013 Volumen 32, 2012 Volumen 31, 2011 Volumen 30, 2010 Volumen 29, 2009 Volumen 28, 2008 Volumen 27, 2007 Volumen 26, 2006 Volumen 25, 2005 Volumen 24, 2004 Volumen 23, 2003 Volumen 22, 2002 Volumen 21, 2001 Volumen 20, 2000 Volumen 19, 1999 Volumen 18, 1998 Volumen 17, 1997 Volumen 16, 1996 Volumen 15, 1995 Volumen 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.2014011600
pages 433-454

Differences in Innate Immune Response between Man and Mouse

Josefin Zschaler
Translational Centre for Regenerative Medicine (TRM); Institute for Medical Physics and Biophysics, Medical Faculty, Leipzig University, Leipzig, Germany
Denise Schlorke
Translational Centre for Regenerative Medicine (TRM); Institute for Medical Physics and Biophysics, Medical Faculty, Leipzig University, Leipzig, Germany
Juergen Arnhold
Translational Centre for Regenerative Medicine (TRM); Institute for Medical Physics and Biophysics, Medical Faculty, Leipzig University, Leipzig, Germany

ABSTRAKT

Mouse strains are frequently used to model human disease states, to test the efficiency of drugs and therapeutic principles. However, the direct translation of murine experimental data to human pathological events often fails due to sufficient differences in the organization of the immune system of both species. Here we give a short overview of the principle differences between mice and humans in defense strategies against pathogens and mechanisms involved in response to pathogenic microorganisms and other activators of the immune system. While in human blood mechanisms of immune resistance are highly prevailed, tolerance mechanisms dominate for the defense against pathogenic microorganisms in mouse blood. Further on, species-related differences of immune cells mainly involved in innate immune response as well as differences to maintain oxidative homeostasis are also considered. A number of disease scenarios in mice are critically reflected for their suitability to serve as a model for human pathologies. Due to setbacks in these studies, novel mouse models were created to bridge the immune system of both species: humanized mice. Accordingly, a special section of this review is devoted to new results applying humanized mouse models taking limitations and prospects into account.


Articles with similar content:

Activation of Natural Killer Cells by Probiotics
Onco Therapeutics, Vol.7, 2016, issue 1-2
Nabil Aziz , Benjamin Bonavida
Regulation of Th17 Maturation by Interleukin 4
Critical Reviews™ in Immunology, Vol.33, 2013, issue 5
Laura A. Cooney , David A. Fox
Inflammation Versus Adaptive Immunity in Cancer Pathogenesis
Critical Reviews™ in Oncogenesis, Vol.15, 2009, issue 1-2
Einar Martin Aandahl, Sheraz Yaqub
Human T-Cell Development and Thymic Egress: An Infectious Disease Perspective
Onco Therapeutics, Vol.6, 2015, issue 1-2
Christel H. Uittenbogaart, Rachel S. Resop
Modeling Physiologic Variability in Human Endotoxemia
Critical Reviews™ in Biomedical Engineering, Vol.40, 2012, issue 4
Steve E. Calvano, Panteleimon D. Mavroudis, Jeremy D. Scheff, Ioannis P. Androulakis, Panagiota T. Foteinou