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ISSN Druckformat: 1040-8401
ISSN Online: 2162-6472
Indexed in
Emerging Roles of Granule Recycling in Mast Cell Plasticity and Homeostasis
ABSTRAKT
Secretory granules (SGs) of mast cells (MCs) release their contents to mediate many biological events and a variety of inflammatory diseases and have important protective roles in innate host defense and pathological functions in allergic reactions and anaphylaxis. There are two modes of MC degranulation during the release of granule contents to the extracellular environment. Anaphylactic degranulation (AND) after IgE-mediated activation is characterized by a rapid swelling and fusion of MC granules as well as abrupt mediators release. Piecemeal degranulation (PMD) is a slow and selective secretion of distinct granule mediators by vesicles shuttling from the granule compartment to the plasma membrane, and it is associated with several chronic diseases. Following degranulation, endocytosis is a fundamental biological event that is necessary to recycle granules and maintain the secretory response during repetitive stimulation. Rapid endocytosis through transient fusion (kiss-and-run, cavicapture and compound exo-endocytosis) has been described in MCs and can also result in the selective release of granule contents. In summary, several possible exo-endocytic mechanisms control the kinetics and magnitude of transmitter release, and each mechanism is associated with a different impact on granule replenishment, cell recovery, and consequently MC function under both normal and pathological conditions.
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Aponte-López Angélica, Fuentes-Pananá Ezequiel M., Cortes-Muñoz Daniel, Muñoz-Cruz Samira, Mast Cell, the Neglected Member of the Tumor Microenvironment: Role in Breast Cancer, Journal of Immunology Research, 2018, 2018. Crossref
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Klein Ofir, Sagi-Eisenberg Ronit, Anaphylactic Degranulation of Mast Cells: Focus on Compound Exocytosis, Journal of Immunology Research, 2019, 2019. Crossref
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Xiong Wei, Yao Mengran, Zhou Rui, Qu Yan, Yang Yuqiao, Wang Zhuoran, Song Ning, Chen Hongmei, Qian Jinqiao, Oxytocin ameliorates ischemia/reperfusion-induced injury by inhibiting mast cell degranulation and inflammation in the rat heart, Biomedicine & Pharmacotherapy, 128, 2020. Crossref