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Critical Reviews™ in Immunology
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ISSN Druckformat: 1040-8401
ISSN Online: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.2013006907
pages 41-56

Homeostatic Regulation of Aging and Rejuvenation in the B Lineage Cells

Doron Melamed
The Rappaport Faculty of Medicine and Research Institute, Department of Immunology, Technion -Israel Institute of Technology, Haifa 31096, Israel

ABSTRAKT

Aging is generally considered a progressive and irreversible process. Age-related alterations in the immune system result in increased susceptibility to infectious diseases and poor responsiveness to vaccination. Recently, several studies have suggested that age-related alterations in hematopoietic and non-hematopoietic tissues can be reversed. In this article we review possible mechanisms for aging in the B lineage and propose a novel hypothesis: altering cellular homeostasis by depletion can reverse aging by reactivating B lymphopoiesis in the bone marrow and rejuvenating the peripheral B cell compartment.


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