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Critical Reviews™ in Therapeutic Drug Carrier Systems
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ISSN Druckformat: 0743-4863
ISSN Online: 2162-660X

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Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v26.i1.20
pages 29-84

Recent Developments of Biodegradable and Biocompatible Materials Based Micro/Nanoparticles for Delivering Macromolecular Therapeutics

Yang Shi
Pharmaceutical College, Shandong University, Ji'nan 250012, China
Guihua Huang
Pharmaceutical College, Shandong University, Ji'nan 250012, China

ABSTRAKT

Developments in biotechnology have seen the growing use of macromolecules containing proteins, peptides, vaccines, antigens, genes, and growth factors as therapeutic agents. Because these macromolecules are easily denatured and metabolized rapidly in vivo, their protection and controlled release are required. Biodegradable and biocompatible materials based micro/nanoparticles (MPs/NPs) show great potential for delivering macromolecular therapeutics. One of the greatest challenges in the delivery of macromolecules from biodegradable and biocompatible MPs/NPs is the controlled and complete release of the drugs in their native forms. Unfortunately, the present drug delivery systems cannot satisfy the requirement; thus, more research is expected. This article discusses the recent developments in the field of macromolecular delivery.


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