Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Critical Reviews™ in Therapeutic Drug Carrier Systems
Impact-faktor: 2.9 5-jähriger Impact-Faktor: 3.72 SJR: 0.573 SNIP: 0.551 CiteScore™: 2.43

ISSN Druckformat: 0743-4863
ISSN Online: 2162-660X

Volumes:
Volumen 36, 2019 Volumen 35, 2018 Volumen 34, 2017 Volumen 33, 2016 Volumen 32, 2015 Volumen 31, 2014 Volumen 30, 2013 Volumen 29, 2012 Volumen 28, 2011 Volumen 27, 2010 Volumen 26, 2009 Volumen 25, 2008 Volumen 24, 2007 Volumen 23, 2006 Volumen 22, 2005 Volumen 21, 2004 Volumen 20, 2003 Volumen 19, 2002 Volumen 18, 2001 Volumen 17, 2000 Volumen 16, 1999 Volumen 15, 1998 Volumen 14, 1997 Volumen 13, 1996 Volumen 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v28.i1.20
pages 47-99

Gastroretentive Floating Drug-Delivery Systems: A Critical Review

Udaya Kotreka
Boehringer Ingelheim Roxane Lboratories, Inc
Moji Christianah Adeyeye
Department of Biopharmaceutical Sciences College of Pharmacy, Roosevelt University, Schaumburg, IL, USA

ABSTRAKT

The oral delivery of drugs with a narrow absorption window in the gastrointestinal tract (GIT) is often limited by poor bioavailability with conventional dosage forms due to incomplete drug release and short residence time at the site of absorption. To overcome this drawback and to maximize the oral absorption of these drugs, gastroretentive systems such as mucoadhesive, high-density, expandable, and floating systems have been developed. These systems provide controlled delivery of drugs with prolonged gastric residence time. However, in humans, differences in various physiological and biological factors can affect the gastric residence time and drug-delivery behavior from gastroretentive systems. Some floating drugdelivery systems (FDDS) have shown the capability to accommodate these variations without affecting drug release. This review mainly focuses on various physiological considerations for development of FDDS, and highlights recent technological developments including new dosage forms and their production techniques (e.g., holt-melt extrusion, melt pelletization, and pulsed plasma-irradiation processes). Alternatives to the existing in vitro compendial methods for evaluating floating dosage forms will be discussed, and a critical analysis of the existing literature on FDDS, identifying the potential areas for future research, is provided.


Articles with similar content:

Pharmacoscintigraphy: A Blazing Trail for the Evaluation of New Drugs and Delivery Systems
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.26, 2009, issue 4
Prateek Dani, Sanyog Jain, Rakesh Kumar Sharma
Current Nanotechnological Strategies for Treating Glaucoma
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.31, 2014, issue 5
Goutam Rath, Tarun Garg, Amit Kumar Goyal, Gagandeep Goyal
Gastric Retentive Dosage Forms: A Review
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.20, 2003, issue 6
Verne E. Cowles, Bret Berner, Sui Yuen Eddie Hou
Stimuli-Responsive Systems with Diverse Drug Delivery and Biomedical Applications: Recent Updates and Mechanistic Pathways
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.34, 2017, issue 3
Ranjot Kaur, Sumant Saini, Bhupinder Singh, Rajneet Kaur Khurana, Babita Garg
Nanosuspensions in Drug Delivery: Recent Advances, Patent Scenarios, and Commercialization Aspects
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.28, 2011, issue 5
Krutika Sawant, Kailash C. Petkar, Sandip S. Chavhan