Erscheint 6 Ausgaben pro Jahr
ISSN Druckformat: 0743-4863
ISSN Online: 2162-660X
IF:
2.7
5-Year IF:
3.6
Immediacy Index:
0.8
Eigenfactor:
0.00023
JCI:
0.39
SJR:
0.42
SNIP:
0.89
CiteScore™::
5.5
H-Index:
79
Indexed in
Transdermal Iontophoresis: Impact on Skin Integrity as Evaluated by Various Methods
Get access
ABSTRAKT
Transdermal iontophoresis, a noninvasive technique that facilitates drug transport through the skin by the use of an external electrical field, has expanded the scope of drugs that can be delivered transdermally and enables programmable drug delivery. In general, transdermal iontophoresis is considered to be a safe procedure, associated with moderate erythema and tingling sensations. However, ensuring that the skin barrier maintains its integrity during iontophoresis is an essential factor to increase its clinical applicability. This review focuses on the effect of transdermal iontophoresis on the integrity of skin, as evaluated by impedance spectroscopy, microscopy, differential scanning calorimetry, infrared spectroscopy, X-ray diffraction, transepidermal water loss, laser doppler velocimetry, visual scoring, chromameter readings, and patient evaluation studies.
-
White Erick A., Orazem Mark E., Bunge Annette L., Characterization of Damaged Skin by Impedance Spectroscopy: Chemical Damage by Dimethyl Sulfoxide, Pharmaceutical Research, 30, 10, 2013. Crossref
-
Amichai Boaz, Mosckovitz Rachel, Trau Henri, Sholto Orit, Ben-Yaakov Shirly, Royz Michael, Barak David, Nitzan Boaz, Shemer Avner, Iontophoretic Terbinafine HCL 1.0% Delivery Across Porcine and Human Nails, Mycopathologia, 169, 5, 2010. Crossref
-
Smith Nadine Barrie, Applications of ultrasonic skin permeation in transdermal drug delivery, Expert Opinion on Drug Delivery, 5, 10, 2008. Crossref
-
Hashim Irhan Ibrahim Abu, Motoyama Keiichi, Abd-ElGawad Abd-ElGawad Helmy, El-Shabouri Mohamed H., Borg Thanaa Mohamed, Arima Hidetoshi, Potential use of iontophoresis for transdermal delivery of NF-κB decoy oligonucleotides, International Journal of Pharmaceutics, 393, 1-2, 2010. Crossref
-
Blaise S, Roustit M, Millet C, Ribuot C, Boutonnat J, Cracowski JL, Cathodal iontophoresis of treprostinil and iloprost induces a sustained increase in cutaneous flux in rats, British Journal of Pharmacology, 162, 3, 2011. Crossref
-
Dielectrics in Allied Disciplines, in Dielectrics in Electric Fields, Second Edition, 2016. Crossref
-
Pattnaik Satyanarayan, Swain Kalpana, Bindhani Amarendra, Mallick Subrata, Influence of chemical permeation enhancers on transdermal permeation of alfuzosin: an investigation using response surface modeling, Drug Development and Industrial Pharmacy, 37, 4, 2011. Crossref
-
Cropek Donald M., Karande Pankaj, Models, Methods, and Measurements in Transdermal Drug Delivery, in Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin, 2017. Crossref
-
Kotzki Sylvain, Roustit Matthieu, Arnaud Claire, Boutonnat Jean, Blaise Sophie, Godin-Ribuot Diane, Cracowski Jean-Luc, Anodal Iontophoresis of a Soluble Guanylate Cyclase Stimulator Induces a Sustained Increase in Skin Blood Flow in Rats, Journal of Pharmacology and Experimental Therapeutics, 346, 3, 2013. Crossref
-
Guarienti Fabiana, Caumo Wolnei, Shiozawa Pedro, Cordeiro Quirino, Boggio Paulo S., Benseñor Isabela M., Lotufo Paulo A., Bikson Marom, Brunoni André R., Reducing Transcranial Direct Current Stimulation-Induced Erythema With Skin Pretreatment: Considerations for Sham-Controlled Clinical Trials, Neuromodulation: Technology at the Neural Interface, 18, 4, 2015. Crossref
-
Shukla Shubhangi, Huston Ryan H., Cox Blake D., Satoskar Abhay R., Narayan Roger J., Transdermal delivery via medical device technologies, Expert Opinion on Drug Delivery, 19, 11, 2022. Crossref