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Critical Reviews™ in Therapeutic Drug Carrier Systems
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ISSN Druckformat: 0743-4863
ISSN Online: 2162-660X

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Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v22.i3.20
pages 295-330

Advances in Buccal Drug Delivery

Raj Birudaraj
TJL School of Pharmacy and Health Sciences, University of the Pacific, Stockton, California, USA. Current address: Roche Palo Alto, Palo Alto, California, USA
Ravichandran Mahalingam
TJL School of Pharmacy and Health Sciences, University of the Pacific, Stockton, California, USA
Xiaoling Li
Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211
Bhaskara R. Jasti
Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211

ABSTRAKT

The buccal route offers an attractive alternative for systemic drug delivery of drugs because of better patient compliance, ease of dosage form removal in emergencies, robustness, and good accessibility. Use of buccal mucosa for drug absorption was first attempted by Sobrero in 1847, and since then much research was done to deliver drugs through this route. Today, research is more focused on the development of suitable delivery devices, permeation enhancement, and buccal delivery of drugs that undergo a first-pass effect, such as cardiovascular drugs, analgesics, and peptides. In addition, studies have been conducted on the development of controlled or slow release delivery systems for systemic and local therapy of diseases in the oral cavity. In this review, the anatomy and physiology of buccal mucosa, followed by discussion of recent literature on the buccal permeation enhancement, and pathways of enhancement for various molecules are detailed. In addition, bioadhesion theories from historic perspective and current status are discussed. The various dosage forms on the market and in different stages of development are also reviewed.


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