Erscheint 6 Ausgaben pro Jahr
ISSN Druckformat: 0743-4863
ISSN Online: 2162-660X
IF:
2.7
5-Year IF:
3.6
Immediacy Index:
0.8
Eigenfactor:
0.00023
JCI:
0.39
SJR:
0.42
SNIP:
0.89
CiteScore™::
5.5
H-Index:
79
Indexed in
A Review on Potential of Proteins as an Excipient for Developing a Nano-Carrier Delivery System
Get access
ABSTRAKT
In neo-age research, nano-materials have emerged as potential tools for the revolution of diagnostic and therapeutic field because of their nano-scale effects, increased surface area–volume ratio, and other beneficial properties. For the last few decades, protein has been regarded as the most attractive and versatile natural bio-macromolecule among all of the available biopolymers. Protein is largely exploited as a nano-carrier system in the pharmaceutical industry due to its low cytotoxocity, biocompatibility, biodegradability, abundant renewable sources, significant attaching ability, clinically useful targeting, and site-specific efficient uptake. This review mainly emphasizes on the latest development and progress achieved in the utilization of protein as a nano-vehicle for a large number of therapeutics such as drugs, genes, hormones, enzymse, nutraceuticals, antibodies, peptides, etc. We also discuss the sources of protein materials, fabrication aspects, advantages, constraints, in vivo and in vitro studies and provide a comparative analysis between the different types of proteins as nano-carriers. The variation of the release pattern and molecular mechanism of the encapsulated molecule with respect to different protein types and various nano-structures are also highlighted here to explore the enormous promises of this novel approach.
-
Singh Mahendra, Singh Navneeta, Chandrasekaran Balakumar, Deb Pran Kishore, Nanomaterials in Nutraceuticals Applications, in Integrative Nanomedicine for New Therapies, 2020. Crossref
-
McClements David Julian, Das Arun K., Dhar Pubali, Nanda Pramod Kumar, Chatterjee Niloy, Nanoemulsion-Based Technologies for Delivering Natural Plant-Based Antimicrobials in Foods, Frontiers in Sustainable Food Systems, 5, 2021. Crossref
-
Dopierała Katarzyna, Krajewska Martyna, Weiss Marek, Physicochemical Characterization of Oleanolic Acid–Human Serum Albumin Complexes for Pharmaceutical and Biosensing Applications, Langmuir, 36, 13, 2020. Crossref
-
Díez-Pascual Ana M., Surface Engineering of Nanomaterials with Polymers, Biomolecules, and Small Ligands for Nanomedicine, Materials, 15, 9, 2022. Crossref
-
Karpagam T., Balamuralikrishnan Balasubramanian, Varalakshmi B., Anand A. Vijaya, Sugunabai J., An Insight on Emerging Nanomaterials for the Delivery of Various Nutraceutical Applications for the Betterment of Heath, in Emerging Nanomaterials for Advanced Technologies, 2022. Crossref
-
Zheng Hongwei, Wang Wenlun, Li Shichang, Han Lin, The Effect of Zbxz23ir-21 NANO(nanomaterials) Delivery Vector on Apoptosis and PTEN(phosphatase and tensin homolog deleted on chromosome ten)/PI3K(Intracellular phosphatidylinositol kinase)/AKT(related to the A and C kinase) in Children with CHOLESTEATOMA in Middle Ear, Bioengineered, 12, 1, 2021. Crossref