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ISSN Druckformat: 0743-4863
ISSN Online: 2162-660X
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The Effective Role of Hydroxyapatite Based Composites in Anticancer Drug Delivery Systems
ABSTRAKT
Tumors consist of a heterogeneous population of cancer cells carrying multiple genetic mutations. During the past few decades, efforts have focused on curing cancer using various methods. However, traditional cancer therapies still carry some drawbacks, such as limited application for only a few cancer types, killing of normal cells, poor specificity, and associated toxicity. To overcome these disadvantages, drug-delivery methods that emphasize biomaterials have been developed and applied to optimize cancer treatments. Hydroxyapatite (HAP) is a biocompatible inorganic material that can be applied in biomedical drug-delivery applications. This review discusses the features and properties of HAP that make it an effective biomaterial and provides a comprehensive summary of recent studies in which HAP and composites containing HAP were applied as anticancer drug carriers. We believe that HAP-based composites show great promise for cancer treatment using controlled release of therapeutic agents, leading to enhanced efficiency, selective release of drugs, and prohibition of cancer cell proliferation.
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Qiao Wei, Lan Xinmiao, Tsoi James K. H., Chen Zhuofan, Su Richard Y. X., Yeung Kelvin W. K., Matinlinna Jukka P., Biomimetic hollow mesoporous hydroxyapatite microsphere with controlled morphology, entrapment efficiency and degradability for cancer therapy, RSC Advances, 7, 71, 2017. Crossref
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Abd-Khorsand Saber, Saber-Samandari Samaneh, Saber-Samandari Saeed, Development of nanocomposite scaffolds based on TiO 2 doped in grafted chitosan/hydroxyapatite by freeze drying method and evaluation of biocompatibility, International Journal of Biological Macromolecules, 101, 2017. Crossref
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Saber-Samandari Samaneh, Mohammadi-Aghdam Mohammad, Saber-Samandari Saeed, A novel magnetic bifunctional nanocomposite scaffold for photothermal therapy and tissue engineering, International Journal of Biological Macromolecules, 138, 2019. Crossref
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