Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Critical Reviews™ in Therapeutic Drug Carrier Systems
Impact-faktor: 2.9 5-jähriger Impact-Faktor: 3.72 SJR: 0.736 SNIP: 0.818 CiteScore™: 4.6

ISSN Druckformat: 0743-4863
ISSN Online: 2162-660X

Volumes:
Volumen 37, 2020 Volumen 36, 2019 Volumen 35, 2018 Volumen 34, 2017 Volumen 33, 2016 Volumen 32, 2015 Volumen 31, 2014 Volumen 30, 2013 Volumen 29, 2012 Volumen 28, 2011 Volumen 27, 2010 Volumen 26, 2009 Volumen 25, 2008 Volumen 24, 2007 Volumen 23, 2006 Volumen 22, 2005 Volumen 21, 2004 Volumen 20, 2003 Volumen 19, 2002 Volumen 18, 2001 Volumen 17, 2000 Volumen 16, 1999 Volumen 15, 1998 Volumen 14, 1997 Volumen 13, 1996 Volumen 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v27.i3.20
pages 237-278

Gemini Amphiphiles: A Novel Class of Nonviral Gene Delivery Vectors

Mukesh Kumar
Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Kalabhavan, Vadodara, Gujarat
Kaustubh Jinturkar
Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Kalabhavan, Vadodara, Gujarat
M.R. Yadav
Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Kalabhavan, Vadodara, Gujarat
Ambikanandan Misra
Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Post Box No. 51, Kalabhavan, Vadodara 390001 Gujarat, India

ABSTRAKT

A number of carriers have been developed for the delivery of genes, but the search for a clinically successful ideal carrier is ongoing. Nonviral carriers, especially cationic liposomes, were developed to resolve issues related to the immunogenicity and oncogenicity of viral carriers. Many synthetic cationic amphiphiles have been synthesized and structurally modified to incorporate genes into vesicular carriers to enhance DNA transfection efficiency and to reduce carrier toxicity. Of these carriers, gemini amphiphiles have demonstrated the suitable physiochemical properties needed for promising and novel gene carriers. Moreover, three basic parts (head, spacer, and chain) in the structure of gemini amphiphiles provide ample opportunities to tailor them according to the needs of specific gene delivery. Initial studies have demonstrated the superiority of gemini amphiphiles in gene delivery efficiency over currently used carriers for gene delivery. This article critically reviews these studies and provides a balanced view to fellow scientists to carry out their efforts in filling in the technological gaps.


Articles with similar content:

Polymeric Gene Carriers
Critical Reviews™ in Eukaryotic Gene Expression, Vol.15, 2005, issue 4
Han Chang Kang, You Han Bae, Minhyung Lee
Structuring Polymers for Delivery of DNA-Based Therapeutics: Updated Insights
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.29, 2012, issue 6
Suresh P. Vyas, Shailja Tiwari, Madhu Gupta
Human Immunodeficiency Virus Type 1 Pharmacogenomics in Clinical Practice: Relevance of HIV-1 Drug Resistance Testing (Part 1)
Journal of Environmental Pathology, Toxicology and Oncology, Vol.22, 2003, issue 3
Nancy G. Klimas, Margaret Marchette, Charles Mitchell, Eduardo Meneses Sierra, Alejandro Isava, Dushyantha Jayaweera, Enriqueta Nunez, J. Brian Page, Gwendolyn Scott, Roberto Patarca, Nelson J. Rodriguez, Mary Ann Fletcher, Delia Rivera, Michael Kolber, Mirtha M. Sanabia, Rafael Campo, Cindy W. Mask, Jose Moreno, Michael Alter, Ricardo Vallejo, Catherine Boulanger
Role of Solid-Gas Interface of Nanobubbles for Therapeutic Applications
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.35, 2018, issue 5
Pravin K. Shende, R. S. Gaud, Drashti Desai
Lipid-Based Cochleates: A Promising Formulation Platform for Oral and Parenteral Delivery of Therapeutic Agents
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.24, 2007, issue 1
Emilio Squillante, III, Kwon H. Kim, Ravi Rao