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Critical Reviews™ in Therapeutic Drug Carrier Systems
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ISSN Druckformat: 0743-4863
ISSN Online: 2162-660X

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Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v26.i4.20
pages 373-426

Pharmacoscintigraphy: A Blazing Trail for the Evaluation of New Drugs and Delivery Systems

Sanyog Jain
Centre for Pharmaceutical Nanotechnology, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), SAS Nagar (Mohali), Punjab, India
Prateek Dani
National Institute of Pharmaceutical Education and Research (NIPER), SAS Nagar (Mohali), Punjab
Rakesh Kumar Sharma
Head, Division of Radiopharmaceuticals and Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brig. SK Mazumdar Road, Delhi-110 054

ABSTRAKT

The drug development process is becoming increasingly sophisticated; as a result, the need for rapid and accurate means of predicting the in vivo behavior of drug products continues to grow. Preclinical in vivo evaluations involve the sacrifice of many animals and hence raise ethical issues. Therefore, noninvasive methods for assessing the in vivo behavior of drug products in animals have become an attractive alternative. Gamma scintigraphy is an established radiological-imaging technique that has been used in medical practice for the past several decades. Gamma scintigraphy is also used during clinical evaluations to map the formulation as it traverses the human body in real time. Combining this information with the pharmacokinetic data gives valuable information about the release and absorption mechanisms of drugs from their products. This technique also provides a handy tool for evaluating formulations at the preclinical and clinical stages of development for researchers who work in targeted drug delivery using novel drug carrier systems. The current review explores the use of pharmacoscintigraphy, a science that integrates gamma scintigraphy and conventional pharmacokinetics in the process of drug development.


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