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Critical Reviews™ in Oncogenesis

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ISSN Druckformat: 0893-9675

ISSN Online: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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The Role of Hox Proteins in Leukemogenesis: Insights Into Key Regulatory Events in Hematopoiesis

Volumen 16, Ausgabe 1-2, 2011, pp. 65-76
DOI: 10.1615/CritRevOncog.v16.i1-2.70
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ABSTRAKT

Acute myeloid leukemia (AML) is a heterogeneous disease with highly variable prognoses. Identification of recurring chromosomal translocations provides some prognostic information for individual AML subjects. Population based gene-expression profiling studies also identified abnormalities relevant to prognosis. Such studies associate increased expression of a set of homeodomain transcription factors with poor prognosis in AML. This set includes HoxB3, B4, A7-11 and Meis1, which are dysregulated as a group in the bone marrow in poor prognosis AML. Aberrant expression of these homeodomain transcription factors is found in AML with chromosomal translocations involving the MLL, MYST3 and CREBBP genes, and in a poor prognosis subset with normal cytogenetics. Studies in murine models suggest that Hox protein overexpression is functionally significant for myeloid malignancies. Overexpression of individual Hox proteins expanded various bone marrow populations in vitro, leading to myeloproliferation and in some cases differentiation block and AML in vivo. Therefore, dysregulated expression of key Hox target genes may contribute to adverse prognosis in AML. Identification of these genes will provide insights into the pathobiology of prognosis in AML. Studies are beginning to identify Hox target genes which may be rational targets for therapeutic approaches to this poor prognosis leukemia subset.

REFERENZIERT VON
  1. Chen Jing, Zhu Shimiao, Jiang Ning, Shang Zhiqun, Quan Changyi, Niu Yuanjie, HoxB3 promotes prostate cancer cell progression by transactivating CDCA3, Cancer Letters, 330, 2, 2013. Crossref

  2. Franks Tobias M., Hetzer Martin W., The role of Nup98 in transcription regulation in healthy and diseased cells, Trends in Cell Biology, 23, 3, 2013. Crossref

  3. Zhao Hang, Zhang Xueqing, Frazão Josias Brito, Condino-Neto Antonio, Newburger Peter E., HOX antisense lincRNA HOXA-AS2 is an apoptosis repressor in allTransretinoic acid treated NB4 promyelocytic leukemia cells, Journal of Cellular Biochemistry, 114, 10, 2013. Crossref

  4. Chen Leonard N., Rubin Rachel S., Othepa Eugide, Cer Caroline, Yun Elizabeth, Agarwal Raghunath P., Collins Brian T., McGeagh Kevin, Pahira John, Bandi Guarav, Kowalczyk Keith, Kumar Deepak, Dritschilo Anatoly, Collins Sean P., Bostwick David G., Lynch John H., Suy Simeng, Correlation of HOXD3 promoter hypermethylation with clinical and pathologic features in screening prostate biopsies, The Prostate, 74, 7, 2014. Crossref

  5. Conway O’Brien Emma, Prideaux Steven, Chevassut Timothy, The Epigenetic Landscape of Acute Myeloid Leukemia, Advances in Hematology, 2014, 2014. Crossref

  6. Zhang Xueqing, Weissman Sherman M, Newburger Peter E, Long intergenic non-coding RNA HOTAIRM1 regulates cell cycle progression during myeloid maturation in NB4 human promyelocytic leukemia cells, RNA Biology, 11, 6, 2014. Crossref

  7. McLaughlin-Drubin Margaret, Munger Karl, Biochemical and Functional Interactions of Human Papillomavirus Proteins with Polycomb Group Proteins, Viruses, 5, 5, 2013. Crossref

  8. Nayak Arnab, Viale-Bouroncle Sandra, Morsczeck Christian, Muller Stefan, The SUMO-Specific Isopeptidase SENP3 Regulates MLL1/MLL2 Methyltransferase Complexes and Controls Osteogenic Differentiation, Molecular Cell, 55, 1, 2014. Crossref

  9. Østrup Olga, Reiner Andrew H., Aleström Peter, Collas Philippe, The specific alteration of histone methylation profiles by DZNep during early zebrafish development, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1839, 11, 2014. Crossref

  10. Li Qiaoyan, Zhu Fufan, Chen Puxiang, miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer, Biochemical and Biophysical Research Communications, 424, 1, 2012. Crossref

  11. Pleyer Lisa, Greil Richard, Digging deep into “dirty” drugs – modulation of the methylation machinery, Drug Metabolism Reviews, 47, 2, 2015. Crossref

  12. Lindblad Oscar, Chougule Rohit A., Moharram Sausan A., Kabir Nuzhat N., Sun Jianmin, Kazi Julhash U., Rönnstrand Lars, The role of HOXB2 and HOXB3 in acute myeloid leukemia, Biochemical and Biophysical Research Communications, 467, 4, 2015. Crossref

  13. He Miao, Chen Ping, Arnovitz Stephen, Li Yuanyuan, Huang Hao, Neilly Mary Beth, Wei Minjie, Rowley Janet D., Chen Jianjun, Li Zejuan, Two isoforms of HOXA9 function differently but work synergistically in human MLL-rearranged leukemia, Blood Cells, Molecules, and Diseases, 49, 2, 2012. Crossref

  14. Collins Cailin T., Hess Jay L., Deregulation of the HOXA9/MEIS1 axis in acute leukemia, Current Opinion in Hematology, 23, 4, 2016. Crossref

  15. Kamkar Fatemeh, Xaymardan Munira, Asli Naisana S., Hox-Mediated Spatial and Temporal Coding of Stem Cells in Homeostasis and Neoplasia, Stem Cells and Development, 25, 17, 2016. Crossref

  16. SONG GUANHUA, WANG LIN, BI KFHONG, JIANG GUOSHENG, Regulation of the C/EBPα signaling pathway in acute myeloid leukemia (Review), Oncology Reports, 33, 5, 2015. Crossref

  17. Luo Hongmei, Qin Yu, Reu Frederic, Ye Sujuan, Dai Yang, Huang Jingcao, Wang Fangfang, Zhang Dan, Pan Ling, Zhu Huanling, Wu Yu, Niu Ting, Xiao Zhijian, Zheng Yuhuan, Liu Ting, Microarray-based analysis and clinical validation identify ubiquitin-conjugating enzyme E2E1 (UBE2E1) as a prognostic factor in acute myeloid leukemia, Journal of Hematology & Oncology, 9, 1, 2016. Crossref

  18. O’Brien Emma Conway, Brewin John, Chevassut Timothy, DNMT3A: the DioNysian MonsTer of acute myeloid leukaemia, Therapeutic Advances in Hematology, 5, 6, 2014. Crossref

  19. KANG JI UN, Characterization of amplification patterns and target genes on the short arm of chromosome 7 in early-stage lung adenocarcinoma, Molecular Medicine Reports, 8, 5, 2013. Crossref

  20. Chaudry Sabah F., Chevassut Timothy J. T., Epigenetic Guardian: A Review of the DNA Methyltransferase DNMT3A in Acute Myeloid Leukaemia and Clonal Haematopoiesis, BioMed Research International, 2017, 2017. Crossref

  21. Hau Ann-Christin, Grebbin Britta Moyo, Agoston Zsuzsa, Anders-Maurer Marie, Müller Tamara, Groß Anja, Kolb Jasmine, Langer Julian D., Döring Claudia, Schulte Dorothea, MEIS homeodomain proteins facilitate PARP1/ARTD1-mediated eviction of histone H1, Journal of Cell Biology, 216, 9, 2017. Crossref

  22. Amali Aseervatham Anusha, Sie Lawrence, Winkler Christoph, Featherstone Mark, Germain Stephane, Zebrafish hoxd4a Acts Upstream of meis1.1 to Direct Vasculogenesis, Angiogenesis and Hematopoiesis, PLoS ONE, 8, 3, 2013. Crossref

  23. Fu Hui, Fu Lei, Xie Chao, Zuo Wen-Shu, Liu Yan-Song, Zheng Mei-Zhu, Yu Jin-Ming, miR-375 inhibits cancer stem cell phenotype and tamoxifen resistance by degrading HOXB3 in human ER-positive breast cancer, Oncology Reports, 37, 2, 2017. Crossref

  24. Johansen Silje, Brenner Annette, Bartaula-Brevik Sushma, Reikvam Håkon, Bruserud Øystein, The Possible Importance of β3 Integrins for Leukemogenesis and Chemoresistance in Acute Myeloid Leukemia, International Journal of Molecular Sciences, 19, 1, 2018. Crossref

  25. Zhang Hongyue, Liu Ying, Yan Lixin, Zhang Min, Yu Xiufeng, Du Wei, Wang Siqi, Li Qiaozhi, Chen He, Zhang Yafeng, Sun Hanliang, Tang Zhidong, Zhu Daling, Increased levels of the long noncoding RNA, HOXA-AS3, promote proliferation of A549 cells, Cell Death & Disease, 9, 6, 2018. Crossref

  26. Zhong Xiaoxia, Prinz Andreas, Steger Julia, Garcia-Cuellar Maria-Paz, Radsak Markus, Bentaher Abderrazzak, Slany Robert K., HoxA9 transforms murine myeloid cells by a feedback loop driving expression of key oncogenes and cell cycle control genes, Blood Advances, 2, 22, 2018. Crossref

  27. Sun Yuqing, Zhou Bo, Mao Fengbiao, Xu Jing, Miao Hongzhi, Zou Zhenhua, Phuc Khoa Le Tran, Jang Younghoon, Cai Sheng, Witkin Matthew, Koche Richard, Ge Kai, Dressler Gregory R., Levine Ross L., Armstrong Scott A., Dou Yali, Hess Jay L., HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis, Cancer Cell, 34, 4, 2018. Crossref

  28. Zhang Hongyue, Liu Ying, Yan Lixin, Wang Siqi, Zhang Min, Ma Cui, Zheng Xiaodong, Chen He, Zhu Daling, Long noncoding RNA Hoxaas3 contributes to hypoxia-induced pulmonary artery smooth muscle cell proliferation, Cardiovascular Research, 115, 3, 2019. Crossref

  29. Slany Robert K., Role of the Trithorax (MLL): HOX Axis in HSC Development, Function, and Leukemia, in Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development, 2014. Crossref

  30. Schulte Dorothea, Geerts Dirk, MEIS transcription factors in development and disease, Development, 146, 16, 2019. Crossref

  31. Zhang Zi-Feng, Wang Yong-Jian, Fan Shao-Hua, Du Shi-Xin, Li Xue-Dong, Wu Dong-Mei, Lu Jun, Zheng Yuan-Lin, MicroRNA-182 downregulates Wnt/β-catenin signaling, inhibits proliferation, and promotes apoptosis in human osteosarcoma cells by targeting HOXA9, Oncotarget, 8, 60, 2017. Crossref

  32. Raymond Aaron, Liu Bin, Liang Hong, Wei Caimiao, Guindani Michele, Lu Yue, Liang Shoudan, St. John Lisa S., Molldrem Jeff, Nagarajan Lalitha, A role for BMP-induced homeobox geneMIXL1in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy, Oncotarget, 5, 24, 2014. Crossref

  33. Zhang Kexin, Yang Xudong, Zhao Qi, Li Zugui, Fu Fangmei, Zhang Hao, Zheng Minying, Zhang Shiwu, Molecular Mechanism of Stem Cell Differentiation into Adipocytes and Adipocyte Differentiation of Malignant Tumor, Stem Cells International, 2020, 2020. Crossref

  34. Nagel Stefan, Pommerenke Claudia, Meyer Corinna, MacLeod Roderick A. F., Drexler Hans G., Bunting Kevin D., Aberrant expression of NKL homeobox genes HMX2 and HMX3 interferes with cell differentiation in acute myeloid leukemia, PLOS ONE, 15, 10, 2020. Crossref

  35. Qu Feng, Zhu Bin, Hu Yi-Lin, Mao Qin-Sheng, Feng Ying, LncRNA HOXA-AS3 promotes gastric cancer progression by regulating miR-29a-3p/LTβR and activating NF-κB signaling, Cancer Cell International, 21, 1, 2021. Crossref

  36. Lisboa Susana, Cerveira Nuno, Bizarro Susana, Correia Cecília, Vieira Joana, Torres Lurdes, Mariz José M, Teixeira Manuel R, POU1F1 is a novel fusion partner of NUP98 in acute myeloid leukemia with t(3;11)(p11;p15), Molecular Cancer, 12, 1, 2013. Crossref

  37. Chen Dajin, Xie Shangzhi, Wu Ying, Cui Yu, Cai Ying, Lan Lan, Yang Hao, Chen Jianghua, Chen Wei, Reduction of Bladder Cancer Chemosensitivity Induced by the Effect of HOXA-AS3 as a ceRNA for miR-455-5p That Upregulates Notch1, Frontiers in Oncology, 10, 2021. Crossref

  38. Wang Hao, Bei Ling, Shah Chirag A., Huang Weiqi, Platanias Leonidas C., Eklund Elizabeth A., The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia, Oncogene, 37, 19, 2018. Crossref

  39. Petrini Marina, Felicetti Federica, Bottero Lisabianca, Errico Maria Cristina, Morsilli Ornella, Boe Alessandra, De Feo Alessandra, Carè Alessandra, HOXB1 restored expression promotes apoptosis and differentiation in the HL60 leukemic cell line, Cancer Cell International, 13, 1, 2013. Crossref

  40. Chen Miao, Qu Yi, Yue Pengjie, Yan Xiaojing, The Prognostic Value and Function of HOXB5 in Acute Myeloid Leukemia, Frontiers in Genetics, 12, 2021. Crossref

  41. Braekeleer Marc De, HOX genes: what their investigation could mean for acute myeloid leukemia, International Journal of Hematologic Oncology, 3, 3, 2014. Crossref

  42. Collins C T, Hess J L, Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets, Oncogene, 35, 9, 2016. Crossref

  43. Breitinger C, Maethner E, Garcia-Cuellar M-P, Schambony A, Fischer K D, Schilling K, Slany R K, HOX genes regulate Rac1 activity in hematopoietic cells through control of Vav2 expression, Leukemia, 27, 1, 2013. Crossref

  44. Collins Cailin, Wang Jingya, Miao Hongzhi, Bronstein Joel, Nawer Humaira, Xu Tao, Figueroa Maria, Muntean Andrew G., Hess Jay L., C/EBPα is an essential collaborator in Hoxa9/Meis1-mediated leukemogenesis, Proceedings of the National Academy of Sciences, 111, 27, 2014. Crossref

  45. Shah Chirag A., Bei Ling, Wang Hao, Platanias Leonidas C., Eklund Elizabeth A., The Leukemia-associated Mll-Ell Oncoprotein Induces Fibroblast Growth Factor 2 (Fgf2)-dependent Cytokine Hypersensitivity in Myeloid Progenitor Cells, Journal of Biological Chemistry, 288, 45, 2013. Crossref

  46. Yao Huilan, Goldman Devorah C., Fan Guang, Mandel Gail, Fleming William H., The Corepressor Rcor1 Is Essential for Normal Myeloerythroid Lineage Differentiation, Stem Cells, 33, 11, 2015. Crossref

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