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ISSN Druckformat: 0893-9675
ISSN Online: 2162-6448
Indexed in
Gaucher's Disease and Cancer: A Sphingolipid Perspective
ABSTRAKT
Gaucher's disease is a sphingolipidosis characterized by a specific deficiency in an acidic glucocerebrosidase, which results in aberrant accumulation of glucosylceramide primarily within the lysosome. Gaucher's disease has been correlated with cases of myeloma, leukemia, glioblastoma, lung cancer, and hepatocellular carcinoma, although the reasons for the correlation are currently being debated. Some suggest that the effects of Gaucher's disease may be linked to cancer, while others implicate the therapies used to treat Gaucher's disease. This debate is not entirely surprising, as the speculations linking Gaucher's disease with cancer fail to address the roles of ceramide and glucosylceramide in cancer biology. In this review, we will discuss, in the context of cancer biology, ceramide metabolism to glucosylceramide, the roles of glucosylceramide in multidrug-resistance, and the role of ceramide as an anticancer lipid. This review should reveal that it is most practical to associate elevated glucosylceramide, which accompanies Gaucher's disease, with the progression of cancer. Furthermore, this review proposes that the therapies used to treat Gaucher's disease, which augment ceramide accumulation, are likely not linked to correlations with cancer.
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Morad Samy A.F., Levin Jonathan C., Tan Su-Fern, Fox Todd E., Feith David J., Cabot Myles C., Novel off-target effect of tamoxifen — Inhibition of acid ceramidase activity in cancer cells, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1831, 12, 2013. Crossref
-
Hafezi-Bakhtiari Sara, Adeyi Oyedele A., Metabolic disorders of the liver, Diagnostic Histopathology, 20, 3, 2014. Crossref
-
Cox Timothy M., Rosenbloom Barry E., Barker Roger A., Gaucher disease and comorbidities: B-cell malignancy and parkinsonism, American Journal of Hematology, 90, 2015. Crossref
-
Astudillo Leonardo, Therville Nicole, Colacios Céline, Ségui Bruno, Andrieu-Abadie Nathalie, Levade Thierry, Glucosylceramidases and malignancies in mammals, Biochimie, 125, 2016. Crossref
-
Linari Silvia, Castaman Giancarlo, Hematological manifestations and complications of Gaucher disease, Expert Review of Hematology, 9, 1, 2016. Crossref
-
Madeo Annalisa, Garaventa Alberto, Sementa Angela Rita, Suffia Chiara, Di Rocco Maja, The unusual association between Neuroblastoma and Gaucher Disease: Case report and review of the literature, Blood Cells, Molecules, and Diseases, 68, 2018. Crossref
-
Thurberg Beth L., Germain Dominique P., Perretta Fernando, Jurca-Simina Iulia E., Politei Juan M., Fabry disease: Four case reports of meningioma and a review of the literature on other malignancies, Molecular Genetics and Metabolism Reports, 11, 2017. Crossref
-
Reali Federico, Morine Melissa J., Kahramanoğulları Ozan, Raichur Suryaprakash, Schneider Hans-Christoph, Crowther Daniel, Priami Corrado, Mechanistic interplay between ceramide and insulin resistance, Scientific Reports, 7, 1, 2017. Crossref
-
Noya MSoledad, Andrade-Campos Marcio, Irun Pilar, López de Frutos Laura, López-Fernandez MFernanda, Giraldo Pilar, Gaucher disease and chronic myeloid leukemia: first reported patient receiving enzyme replacement and tyrosine kinase inhibitor therapies simultaneously, Clinical Case Reports, 6, 5, 2018. Crossref
-
Wątek Marzena, Piktel Ewelina, Wollny Tomasz, Durnaś Bonita, Fiedoruk Krzysztof, Lech-Marańda Ewa, Bucki Robert, Defective Sphingolipids Metabolism and Tumor Associated Macrophages as the Possible Links Between Gaucher Disease and Blood Cancer Development, International Journal of Molecular Sciences, 20, 4, 2019. Crossref
-
Chadha Juskaran, Sahai Tanmay, Schwimmer Joshua, Shani Dana, A 30-Year-Old Carrier of Gaucher Disease with Multiple Myeloma, Case Reports in Oncological Medicine, 2019, 2019. Crossref
-
Isali Ilaha, Mahran Amr, Khalifa Ahmad O., Sheyn David, Neudecker Mandy, Qureshi Arshna, Conroy Britt, Schumacher Fredrick R., Hijaz Adonis K., El-Nashar Sherif A., Gene expression in stress urinary incontinence: a systematic review, International Urogynecology Journal, 31, 1, 2020. Crossref
-
Winter Aaron W, Salimi Ali, Ospina Luis H, Roos Jonathan C P, Ophthalmic manifestations of Gaucher disease: the most common lysosomal storage disorder, British Journal of Ophthalmology, 103, 3, 2019. Crossref
-
Dei Cas Michele, Zulueta Aida, Mingione Alessandra, Caretti Anna, Ghidoni Riccardo, Signorelli Paola, Paroni Rita, An Innovative Lipidomic Workflow to Investigate the Lipid Profile in a Cystic Fibrosis Cell Line, Cells, 9, 5, 2020. Crossref
-
Önal Gizem, Gümüş Ersin, Demir Hülya, Yüce Aysel, Dökmeci (Emre) Serap, Molecular genetic analysis of Turkish Gaucher's disease patients reveals three novel variants in Glucocerebrosidase (GBA) gene, Meta Gene, 25, 2020. Crossref
-
Chai Annie Wai Yeeng, Yee Pei San, Price Stacey, Yee Shi Mun, Lee Hui Mei, Tiong Vivian KH, Gonçalves Emanuel, Behan Fiona M, Bateson Jessica, Gilbert James, Tan Aik Choon, McDermott Ultan, Garnett Mathew J, Cheong Sok Ching, Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway, eLife, 9, 2020. Crossref
-
Giraldo Pilar, Andrade-Campos Marcio, Novel Management and Screening Approaches for Haematological Complications of Gaucher’s Disease, Journal of Blood Medicine, Volume 12, 2021. Crossref
-
Petrusca Daniela N., Lee Kelvin P., Galson Deborah L., Role of Sphingolipids in Multiple Myeloma Progression, Drug Resistance, and Their Potential as Therapeutic Targets, Frontiers in Oncology, 12, 2022. Crossref
-
Ung Johnson, Tan Su-Fern, Fox Todd E., Shaw Jeremy J.P., Vass Luke R., Costa-Pinheiro Pedro, Garrett-Bakelman Francine E., Keng Michael K., Sharma Arati, Claxton David F., Levine Ross L., Tallman Martin S., Cabot Myles C., Kester Mark, Feith David J., Loughran Thomas P., Harnessing the power of sphingolipids: Prospects for acute myeloid leukemia, Blood Reviews, 55, 2022. Crossref
-
McCluskey Gavin, Donaghy Colette, Morrison Karen E., McConville John, Duddy William, Duguez Stephanie, The Role of Sphingomyelin and Ceramide in Motor Neuron Diseases, Journal of Personalized Medicine, 12, 9, 2022. Crossref
-
Uzen Ramazan, Bayram Fahri, Dursun Huseyin, Kardas Fatih, Altın-Celik Pınar, Cakir Mustafa, Eken Ahmet, Cucer Nurhan, Donmez-Altuntas Hamiyet, Oxidative and chromosomal DNA damage in patients with type I Gaucher disease and carriers, Clinical Biochemistry, 111, 2023. Crossref