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Critical Reviews™ in Oncogenesis

Erscheint 4 Ausgaben pro Jahr

ISSN Druckformat: 0893-9675

ISSN Online: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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Evolving Views of Breast Cancer Stem Cells and Their Differentiation States

Volumen 19, Ausgabe 5, 2014, pp. 337-348
DOI: 10.1615/CritRevOncog.2014011799
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ABSTRAKT

Cellular heterogeneity is a prominent characteristic of breast cancers, and accumulating evidence indicates that variability in the differentiation state of tumor cells contributes to this phenomenon. Breast cancers are among the tumor types in which the existence of cancer stem cells has been widely supported, and specific markers, including CD44/CD24 and ALDH1, have been consistently used to identify such cells. Recent studies have revealed the potential for dynamic bidirectional transitions of breast cancer cells between differentiated and stem-like phenotypes. In addition, the potential importance of intermediate states along differentiation axes, including the epithelial-to-mesenchymal transition and the basal−luminal differentiation axis, has emerged. These findings provide a view of breast cancer stem cells that departs from the traditional unidirectional hierarchical model, as well as new insights into the mechanisms by which differentiation events contribute to breast cancer biology. Herein we discuss these advances.

REFERENZIERT VON
  1. N. Goltsev Anatoliy, A. Diabina Olga, V. Ostankov Maksim, A. Bondarovich Nikolay, Ye. Yampolskaya Ekaterina, Cancer stem cells in tumor pathogenesis after cryoablation, Problems of Cryobiology and Cryomedicine, 25, 3, 2015. Crossref

  2. Bliss Sarah A., Paul Sunirmal, Pobiarzyn Piotr W., Ayer Seda, Sinha Garima, Pant Saumya, Hilton Holly, Sharma Neha, Cunha Maria F., Engelberth Daniel J., Greco Steven J., Bryan Margarette, Kucia Magdalena J., Kakar Sham S., Ratajczak Mariusz Z., Rameshwar Pranela, Evaluation of a developmental hierarchy for breast cancer cells to assess risk-based patient selection for targeted treatment, Scientific Reports, 8, 1, 2018. Crossref

  3. Yosef Reut, Pilpel Noam, Papismadov Nurit, Gal Hilah, Ovadya Yossi, Vadai Ezra, Miller Stav, Porat Ziv, Ben‐Dor Shifra, Krizhanovsky Valery, p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling , The EMBO Journal, 36, 15, 2017. Crossref

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