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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN Druckformat: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.2017021114
pages 447-458

Therapeutic Potential of Nitric Oxide Donors in Cancer: Focus on Angiogenesis

Lucia Morbidelli
Lab of Pharmacology of Angiogenesis and Microcirculation, Department of Life Sciences, University of Siena Via A. Moro 2, 53100 Siena, Italy

ABSTRAKT

A new challenge to overcoming tumor resistance to conventional treatment is represented by the development of novel nitric oxide (NO) donors. It is now clear that while low doses of NO have proneoplastic properties, high doses exert antitumor/antiangiogenic activities through multiple mechanisms. This review focuses on the role of exogenous NO in cancer therapy and reports the state of the art regarding different NO-donating agents in cancer treatment, particularly in relation to angiogenesis inhibition.