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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2.2

ISSN Druckformat: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.v7.i1-2.30
pages 33-48

The ABL Genes in Normal and Abnormal Cell Development

Siu-Wah Chung
The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine
Rene Daniel
The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine
Bryan Y. Wong
The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine
Peter M. C. Wong
The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine

ABSTRAKT

Genetic alteration of the c-abl protooncogene has led to abnormal cellular development, primarily within the hemopoietic system. Different forms of oncogenic alteration have variations in biological strength for cellular transformation. The abnormal Abl oncoproteins are known to suppress apoptosis, which may be the basis for causing leukemia development. However, recent evidence also shows that c-abl proto-oncoprotein can inhibit apoptosis. Expression of the Abl oncoprotein in hemopoietic stem cells (HSCs) also results in alteration in the expression of certain cell surface molecules such that the interaction between HSCs and their marrow stroma microenvironment has become abnormal. The basis for the genetic alteration of the c-abl protooncogene in patients with chronic myelogenous leukemia may or may not be due to genetic imprinting.


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