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Critical Reviews™ in Oncogenesis
SJR: 0.946 SNIP: 0.503 CiteScore™: 2

ISSN Druckformat: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.2014011950
pages 497-504

Interactions of RKIP with Inflammatory Signaling Pathways

Jinming Zhao
University of Pittsburgh Asthma Institute at UPMC/Pulmonary Allergy and Critical Care Medicine Division, University of Pittsburgh, Pittsburgh, Pennsylvania
Sally Wenzel
University of Pittsburgh Asthma Institute at UPMC/Pulmonary Allergy and Critical Care Medicine Division, University of Pittsburgh, Pittsburgh, Pennsylvania

ABSTRAKT

The inflammatory response plays an important role in host defense and maintenance of homeostasis, while imbalances in these responses can also lead to pathologic disease processes. Emerging data show that RKIP interacts with multiple signaling molecules that may potentiate multiple functions during inflammatory processes. Here, we review the interaction of RKIP with both the MAPK and NF-κB pathways in relation to chronic inflammatory diseases. In these settings, it can both inhibit inflammatory pathways as well contribute to pro-inflammatory signaling, often depending on the interactions with multiple proteins and perhaps lipids. The interactions of RKIP with proteins, phospholipids, fatty acids, and their enzymes thus could play a substantial role in diseases like asthma and diabetes. Targeting interactions of RKIP with these pathways could lead to novel approaches to treatment.

SCHLÜSSELWÖRTER: 15-lipoxygenase-1, MUC5AC, RKIP, NF-κB, asthma

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