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ISSN Druckformat: 0893-9675
ISSN Online: 2162-6448
Indexed in
Interactions of RKIP with Inflammatory Signaling Pathways
ABSTRAKT
The inflammatory response plays an important role in host defense and maintenance of homeostasis, while imbalances in these responses can also lead to pathologic disease processes. Emerging data show that RKIP interacts with multiple signaling molecules that may potentiate multiple functions during inflammatory processes. Here, we review the interaction of RKIP with both the MAPK and NF-κB pathways in relation to chronic inflammatory diseases. In these settings, it can both inhibit inflammatory pathways as well contribute to pro-inflammatory signaling, often depending on the interactions with multiple proteins and perhaps lipids. The interactions of RKIP with proteins, phospholipids, fatty acids, and their enzymes thus could play a substantial role in diseases like asthma and diabetes. Targeting interactions of RKIP with these pathways could lead to novel approaches to treatment.
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Gelberman Richard H., Shen Hua, Kormpakis Ioannis, Rothrauff Benjamin, Yang Guang, Tuan Rocky S., Xia Younan, Sakiyama-Elbert Shelly, Silva Matthew J., Thomopoulos Stavros, Effect of adipose-derived stromal cells and BMP12 on intrasynovial tendon repair: A biomechanical, biochemical, and proteomics study, Journal of Orthopaedic Research, 34, 4, 2016. Crossref
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Shvartsur Anna, Givechian Kevin B., Garban Hermes, Bonavida Benjamin, Overexpression of RKIP and its cross-talk with several regulatory gene products in multiple myeloma, Journal of Experimental & Clinical Cancer Research, 36, 1, 2017. Crossref
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-
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-
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-
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-
Kashfi Khosrow, Zhou Yongxin, Corrente Gabrielle M., RKIP a master of regulatory pathways: Perspectives, in Prognostic and Therapeutic Applications of RKIP in Cancer, 2020. Crossref
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