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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2.2

ISSN Druckformat: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.2013007176
pages 289-302

MicroRNAs as New Diagnostic and Prognostic Biomarkers in Urological Tumors

Annika Fendler
Department of Urology, Charité - University Medicine and Berlin Institute for Urological Research, Berlin, Germany
Klaus Jung
Department of Urology, Charité - University Medicine and Berlin Institute for Urological Research, Berlin, Germany

ABSTRAKT

MicroRNAs are single-stranded regulatory molecules that play an important role during carcinogenesis. Since microRNA expressions are deregulated in cancer and they have proven to be very stable in clinical specimens, they have become attractive molecules as markers for the diagnosis and prognosis, as well as for prediction of therapy response and surveillance, of cancer. In this review, we summarize the latest findings on microRNAs in tissue and body fluids of patients suffering from urological tumors and their utilization as noninvasive or tissue markers for detection and stratification of these tumors.


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