Erscheint 4 Ausgaben pro Jahr
ISSN Druckformat: 0893-9675
ISSN Online: 2162-6448
Indexed in
The Insulin-Like Growth Factor-I Receptor Signaling Pathways Are Important for Tumorigenesis and Inhibition of Apoptosis
ABSTRAKT
The biological actions of the insulin-like growth factors IGF-I and IGF-II are mediated by their activation of the IGF-IR, a transmembrane tyrosine kinase linked to the ras-raf-MAPK cascade. Functional IGF-IRs are required for the cell to progress through the cell cycle. Most importantly, cells lacking this receptor cannot be transformed by any of a number of dominant oncogenes, a finding that proves that the presence of the IGF-IR is important for the development of a malignant phenotype. Consistent with this role, the IGF-IR displays a potent antiapoptotic effect, both in vitro and in vivo. Because of its key role in the transformation process, the IGF-IR is actively studied as a potential therapeutic target in different types of neoplastic growth.
-
Phan T.T., See P., Tran E., Nguyen T.T.T., Chan S.Y., Lee S.T., Huynh H., Suppression of insulin-like growth factor signalling pathway and collagen expression in keloid-derived fibroblasts by quercetin: its therapeutic potential use in the treatment and/or prevention of keloids, British Journal of Dermatology, 148, 3, 2003. Crossref
-
Cooke David W., Divall Sara A., Radovick Sally, Normal and Aberrant Growth, in Williams Textbook of Endocrinology, 2011. Crossref
-
Anderson John, Gordon Anthony, Pritchard-Jones Kathy, Shipley Janet, Genes, chromosomes, and rhabdomyosarcoma, Genes, Chromosomes and Cancer, 26, 4, 1999. Crossref
-
Ferlin Martine, Noraz Nelly, Hertogh Catherine, Brochier Jean, Taylor Naomi, Klein Bernard, Insulin-like growth factor induces the survival and proliferation of myeloma cells through an interleukin-6-independent transduction pathway, British Journal of Haematology, 111, 2, 2000. Crossref
-
Kundu Anup Kumer, Nagaoka Masato, Chowdhury Ezharul Hoque, Hirose Shinichi, Sasagawa Tadashi, Akaike Toshihiro, IGF-1 Induces Growth, Survival and Morphological Change of Primary Hepatocytes on a Galactose-bared Polymer through both MAPK and .BETA.-catenin Pathways, Cell Structure and Function, 28, 4, 2003. Crossref
-
Carelli Stephana, Di Giulio Anna Maria, Paratore Simona, Bosari Silvano, Gorio Alfredo, Degradation of insulin-like growth factor-I receptor occurs via ubiquitin-proteasome pathway in human lung cancer cells, Journal of Cellular Physiology, 208, 2, 2006. Crossref
-
Garza-Garcia Acely, Patel Dhaval S., Gems David, Driscoll Paul C., RILM: a web-based resource to aid comparative and functional analysis of the insulin and IGF-1 receptor family, Human Mutation, 28, 7, 2007. Crossref
-
Stoeltzing Oliver, Liu Wenbiao, Reinmuth Niels, Fan Fan, Parikh Alexander A., Bucana Corazon D., Evans Douglas B., Semenza Gregg L., Ellis Lee M., Regulation of Hypoxia-Inducible Factor-1α, Vascular Endothelial Growth Factor, and Angiogenesis by an Insulin-Like Growth Factor-I Receptor Autocrine Loop in Human Pancreatic Cancer, The American Journal of Pathology, 163, 3, 2003. Crossref
-
Chakravarti Bandana, Siddiqui Jawed A., Dwivedi Shailendra K. Dhar, Deshpande Shreekant, Samanta Krishnanda, Bhatta Rabi S., Panda Gautam, Prabhakar Yenamandra S., Konwar Rituraj, Sanyal Sabaysachi, Chattopadhyay Naibedya, Specific targeting of insulin-like growth factor 1 receptor signaling in human estrogen dependent breast cancer cell by a novel tyrosine-based benzoxazepine derivative, Molecular and Cellular Endocrinology, 338, 1-2, 2011. Crossref
-
de Assis Sonia, Khan Galam, Hilakivi-Clarke Leena, High birth weight increases mammary tumorigenesis in rats, International Journal of Cancer, 119, 7, 2006. Crossref
-
Madden Tracie-Ann, Bryant Sian, Gee Julia, Cellular and molecular actions of estrogens and antiestrogens in breast cancer, in Endocrine Management of Breast Cancer, 2002. Crossref
-
Slattery Martha L., Single nucleotide polymorphisms in sporadic colorectal cancer, Current Colorectal Cancer Reports, 2, 4, 2006. Crossref
-
Reinmuth Niels, Fan Fan, Liu Wenbiao, Parikh Alexander A, Stoeltzing Oliver, Jung Young D, Bucana Corazon D, Radinsky Robert, Gallick Gary E, Ellis Lee M, Impact of Insulin-Like Growth Factor Receptor-I Function on Angiogenesis, Growth, and Metastasis of Colon Cancer, Laboratory Investigation, 82, 10, 2002. Crossref
-
Medová Michaela, Aebersold Daniel, Zimmer Yitzhak, The Molecular Crosstalk between the MET Receptor Tyrosine Kinase and the DNA Damage Response—Biological and Clinical Aspects, Cancers, 6, 1, 2013. Crossref
-
Introduction: Uveal melanoma, Acta Ophthalmologica, 86, thesis4, 2008. Crossref
-
Pramojanee Sakarat N., Phimphilai Mattabhorn, Chattipakorn Nipon, Chattipakorn Siriporn C., Possible roles of insulin signaling in osteoblasts, Endocrine Research, 39, 4, 2014. Crossref
-
Maltais Simon, Tremblay Jacques P., Perrault Louis P., Ly Hung Q., The Paracrine Effect: Pivotal Mechanism in Cell-Based Cardiac Repair, Journal of Cardiovascular Translational Research, 3, 6, 2010. Crossref
-
Gooch Jennifer L., Van Den Berg Carla L., Yee Douglas, Insulin‐like growth factor (IGF)‐I rescues breast cancer cells from chemotherapy‐induced cell death – proliferative and anti‐apoptotic effects, Breast Cancer Research and Treatment, 56, 1, 1999. Crossref
-
Verhagen H JMP, de Leeuw D C, Roemer M GM, Denkers F, Pouwels W, Rutten A, Celie P H, Ossenkoppele G J, Schuurhuis G J, Smit L, IGFBP7 induces apoptosis of acute myeloid leukemia cells and synergizes with chemotherapy in suppression of leukemia cell survival, Cell Death & Disease, 5, 6, 2014. Crossref
-
Roschier Maaria, Kuusisto Erkki, Suuronen Tiina, Korhonen Pauliina, Kyrylenko Sergiy, Salminen Antero, Insulin-like growth factor binding protein 5 and type-1 insulin-like growth factor receptor are differentially regulated during apoptosis in cerebellar granule cells, Journal of Neurochemistry, 76, 1, 2008. Crossref
-
Hu Z.‐C., Tang B., Guo D., Zhang J., Liang Y.‐Y., Ma D., Zhu J.‐Y., Expression of insulin‐like growth factor‐1 receptor in keloid and hypertrophic scar, Clinical and Experimental Dermatology, 39, 7, 2014. Crossref
-
Economou Mario A., All-Ericsson Charlotta, Bykov Vladimir, Girnita Leonard, Bartolazzi Armando, Larsson Olle, Seregard Stefan, Receptors for the liver synthesized growth factors IGF-1 and HGF/SF in uveal melanoma: intercorrelation and prognostic implications, Acta Ophthalmologica, 86, thesis4, 2008. Crossref
-
Anderson John, Gordon Anthony, McManus Aidan, Shipley Janet, Pritchard-Jones Kathy, Disruption of Imprinted Genes at Chromosome Region 11p15.5 in Paediatric Rhabdomyosarcoma, Neoplasia, 1, 4, 1999. Crossref
-
Neilsen Paul M., Pishas Kathleen I., Callen David F., Thomas David M., Targeting the p53 Pathway in Ewing Sarcoma, Sarcoma, 2011, 2011. Crossref
-
Ferlin Martine, Noraz Nelly, Hertogh Catherine, Brochier Jean, Taylor Naomi, Klein Bernard, Insulin-like growth factor induces the survival and proliferation of myeloma cells through an interleukin-6-independent transduction pathway, British Journal of Haematology, 111, 2, 2000. Crossref
-
Katz J, Nasatzky E, Werner H, Roith D.Le, Shemer J, Tumor necrosis factor α and interferon γ– induced cell growth arrest is mediated via insulin-like growth factor binding protein-3, Growth Hormone & IGF Research, 9, 3, 1999. Crossref
-
Yakar Shoshana, LeRoith Derek, Brodt Pnina, The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models, Cytokine & Growth Factor Reviews, 16, 4-5, 2005. Crossref
-
Bähr Corinna, Groner Bernd, The insulin like growth factor-1 receptor (IGF-1R) as a drug target: novel approaches to cancer therapy, Growth Hormone & IGF Research, 14, 4, 2004. Crossref
-
Himpe Eddy, Potikanond Saranyapin, Verdood Peggy, Kooijman Ron, Attenuation of IGF-I receptor signaling inhibits serum-induced proliferation of prostate cancer cells, Growth Hormone & IGF Research, 21, 5, 2011. Crossref
-
Sarfstein Rive, Maor Sharon, Reizner Naama, Abramovitch Shirley, Werner Haim, Transcriptional regulation of the insulin-like growth factor-I receptor gene in breast cancer, Molecular and Cellular Endocrinology, 252, 1-2, 2006. Crossref
-
Elmlinger Martin W, Rauschnabel Uta, Koscielniak Ewa, Haenze Jörg, Ranke Michael B, Berthold Antje, Klammt Jürgen, Kiess Wieland, Correlation of type I insulin-like growth factor receptor (IGF-I-R) and insulin receptor-related receptor (IRR) messenger RNA levels in tumor cell lines from pediatric tumors of neuronal origin, Regulatory Peptides, 84, 1-3, 1999. Crossref
-
Pomati Francesco, Cotsapas Chris J., Castiglioni Sara, Zuccato Ettore, Calamari Davide, Gene expression profiles in zebrafish (Danio rerio) liver cells exposed to a mixture of pharmaceuticals at environmentally relevant concentrations, Chemosphere, 70, 1, 2007. Crossref
-
Sandow Juergen, Hormones, 1. Hormone Systems, in Ullmann's Encyclopedia of Industrial Chemistry, 2011. Crossref
-
Werner Haim, Shalita-Chesner Michal, Abramovitch Shirley, Idelman Gila, Shaharabani-Gargir Limor, Glaser Tova, Regulation of the Insulin-Like Growth Factor-I Receptor Gene by Oncogenes and Antioncogenes: Implications in Human Cancer, Molecular Genetics and Metabolism, 71, 1-2, 2000. Crossref
-
Reinmuth Niels, Mesters Rolf M., Bieker Ralf, Hoffknecht Petra, Berdel Wolfgang E., Thomas Michael, Signal transduction pathways as novel therapy targets in lung cancer, Lung Cancer, 45, 2004. Crossref
-
Sampognaro Anthony J., Wittman Mark D., Carboni Joan M., Chang Chiehying, Greer Ann F., Hurlburt Warren W., Sack John S., Vyas Dolatrai M., Proline isosteres in a series of 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitors of IGF-1R kinase and IR kinase, Bioorganic & Medicinal Chemistry Letters, 20, 17, 2010. Crossref
-
Stoll B.A, Alcohol intake and late-stage promotion of breast cancer, European Journal of Cancer, 35, 12, 1999. Crossref
-
Warsito Dudi, Sjöström Sylvia, Andersson Sandra, Larsson Olle, Sehat Bita, Nuclear IGF1R is a transcriptional co‐activator of LEF1/TCF, EMBO reports, 13, 3, 2012. Crossref
-
Bostedt Katalin Tisa, Schmid Christoph, Ghirlanda-Keller Claudia, Olie Robert, Winterhalter Kaspar H., Zapf Jürgen, Insulin-like Growth Factor (IGF) I Down-Regulates Type 1 IGF Receptor (IGF 1R) and Reduces the IGF I Response in A549 Non-Small-Cell Lung Cancer and Saos-2/B-10 Osteoblastic Osteosarcoma Cells, Experimental Cell Research, 271, 2, 2001. Crossref
-
Brady Garrett, Crean St John, Lorenzon Ana, Kapas Supriya, IGF-I protects human oral buccal mucosal epithelial cells from sodium nitroprusside-induced apoptosis via PI3-kinase, Growth Hormone & IGF Research, 18, 4, 2008. Crossref
-
Hayati Abdul Rahman, Cheah Fook Choe, Tan Ay Eeng, Tan Geok Chin, Insulin-like growth factor-1 receptor expression in the placentae of diabetic and normal pregnancies, Early Human Development, 83, 1, 2007. Crossref
-
Zhang Youcheng, Zhang Yawu, Growth Inhibition of Insulin-Like Growth Factor I Receptor Monoclonal Antibody to Human Colorectal Cancer Cells, Cancer Investigation, 26, 3, 2008. Crossref
-
ROSENFELD RON G., COHEN PINCHAS, Disorders of Growth Hormone/Insulin-like Growth Factor Secretion and Action, in Pediatric Endocrinology, 2008. Crossref
-
Riesterer Oliver, Yang Qiuan, Raju Uma, Torres Mylin, Molkentine David, Patel Nalini, Valdecanas David, Milas Luka, Ang K. Kian, Combination of Anti-IGF-1R Antibody A12 and Ionizing Radiation in Upper Respiratory Tract Cancers, International Journal of Radiation Oncology*Biology*Physics, 79, 4, 2011. Crossref
-
Mitsiades Constantine S, Mitsiades Nicholas S, McMullan Ciaran J, Poulaki Vassiliki, Shringarpure Reshma, Akiyama Masaharu, Hideshima Teru, Chauhan Dharminder, Joseph Marie, Libermann Towia A, Garcı́a-Echeverrı́a Carlos, Pearson Mark A, Hofmann Francesco, Anderson Kenneth C, Kung Andrew L, Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors, Cancer Cell, 5, 3, 2004. Crossref
-
Shevah O., Laron Z., Patients with congenital deficiency of IGF-I seem protected from the development of malignancies: A preliminary report, Growth Hormone & IGF Research, 17, 1, 2007. Crossref
-
Koniaris Leonidas G, McKillop Iain H, Schwartz Seymour I, Zimmers Teresa A, Liver Regeneration, Journal of the American College of Surgeons, 197, 4, 2003. Crossref
-
Abramovitch Shirley, Glaser Tova, Ouchi Toru, Werner Haim, BRCA1-Sp1 interactions in transcriptional regulation of the IGF-IR gene, FEBS Letters, 541, 1-3, 2003. Crossref
-
Ayalon D., Glaser T., Werner H., Transcriptional regulation of IGF-I receptor gene expression by the PAX3–FKHR oncoprotein, Growth Hormone & IGF Research, 11, 5, 2001. Crossref
-
Jerome Lori, Shiry Laura, Leyland-Jones Brian, Anti-insulin-like growth factor strategies in breast cancer, Seminars in Oncology, 31, 2004. Crossref
-
Martin David C., Fowlkes John L., Babic Bojana, Khokha Rama, Insulin-like Growth Factor II Signaling in Neoplastic Proliferation Is Blocked by Transgenic Expression of the Metalloproteinase Inhibitor Timp-1, Journal of Cell Biology, 146, 4, 1999. Crossref
-
Park Hae, Kim Su, Kang Won, Park Jin, Kim Young, Nam Min, Kim Jong, Chung Joo-Ho, Association between IRS1 Gene Polymorphism and Autism Spectrum Disorder: A Pilot Case-Control Study in Korean Males, International Journal of Molecular Sciences, 17, 8, 2016. Crossref
-
Woźniak Marta, Duś-Szachniewicz Kamila, Ziółkowski Piotr, Insulin-Like Growth Factor-2 Is Induced Following 5-Aminolevulinic Acid-Mediated Photodynamic Therapy in SW620 Human Colon Cancer Cell Line, International Journal of Molecular Sciences, 16, 10, 2015. Crossref
-
Philippou Anastassios, Christopoulos Panagiotis F., Koutsilieris Dr. Michael, Clinical studies in humans targeting the various components of the IGF system show lack of efficacy in the treatment of cancer, Mutation Research/Reviews in Mutation Research, 772, 2017. Crossref
-
Gee Julia, Nicholson Robert, The Breast Cancer Phenotype and Endocrine Response, in Breast Cancer, 2002. Crossref
-
Kanter-Lewensohn Lena, Dricu Anica, Girnita Leonard, Wejde Johan, Larsson Olle, Expression of Insulin-Like Growth Factor-1 Receptor (IGF-1R) and p27Kip1in Melanocyte Tumors: A Potential Regulatory Role of IGF-1 Pathway in Distribution of p27Kip1between Different Cyclins, Growth Factors, 17, 3, 2000. Crossref
-
Gurtunca Nursen, Sperling Mark A., Growth Hormone, Prolactin, and Placental Lactogen in the Fetus and Newborn, in Fetal and Neonatal Physiology, 2017. Crossref
-
Moorehead R A, Fata J E, Johnson M B, Khokha R, Inhibition of mammary epithelial apoptosis and sustained phosphorylation of Akt/PKB in MMTV-IGF-II transgenic mice, Cell Death & Differentiation, 8, 1, 2001. Crossref
-
Oh Hyun-Seok, Oh Se Kwan, Lee Jum Seek, Wu Chunyan, Lee Sung-Joon, Effects of l-arginine on growth hormone and insulin-like growth factor 1, Food Science and Biotechnology, 26, 6, 2017. Crossref
-
Werner H., Katz J., The Emerging Role of the Insulin-like Growth Factors in Oral Biology, Journal of Dental Research, 83, 11, 2004. Crossref
-
Santoro M. Agostina, Blue R. Eric, Andres Sarah F., Mah Amanda T., Van Landeghem Laurianne, Lund P. Kay, Obesity and intestinal epithelial deletion of the insulin receptor, but not the IGF 1 receptor, affect radiation-induced apoptosis in colon, American Journal of Physiology-Gastrointestinal and Liver Physiology, 309, 7, 2015. Crossref
-
Shi Liang-Hui, Expression of insulin-like growth factor binding protein-2 in gastric carcinoma and its relationship with cell proliferation, World Journal of Gastroenterology, 12, 39, 2006. Crossref
-
Marshman Emma, Streuli Charles H, Insulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function, Breast Cancer Research, 4, 6, 2002. Crossref
-
Schneider Marlon R., Lahm Harald, Wu Minyao, Hoeflich Andreas, Wolf Eckhard, Transgenic mouse models for studying the functions of insulin‐like growth factor‐binding proteins, The FASEB Journal, 14, 5, 2000. Crossref
-
Rezzónico Jorge N., Rezzónico Mariana, Pusiol Eduardo, Pitoia Fabian, Niepomniszcze Hugo, Increased Prevalence of Insulin Resistance in Patients With Differentiated Thyroid Carcinoma, Metabolic Syndrome and Related Disorders, 7, 4, 2009. Crossref
-
Geller James I., Dome Jeffrey S., Molecular Targeted Therapy for Wilms’ Tumor, in Molecularly Targeted Therapy for Childhood Cancer, 2010. Crossref
-
Kelleher Fergal C, Thomas David M, Molecular pathogenesis and targeted therapeutics in Ewing sarcoma/primitive neuroectodermal tumours, Clinical Sarcoma Research, 2, 1, 2012. Crossref
-
Liu Wenli, Liu Yueqin, Lowe Jr. William L., The Role of Phosphatidylinositol 3-Kinase and the Mitogen-Activated Protein Kinases in Insulin-Like Growth Factor-I-Mediated Effects in Vascular Endothelial Cells*, Endocrinology, 142, 5, 2001. Crossref
-
Monno Satoshi, Newman Marsha V., Cook Michelle, Lowe William L., Insulin-Like Growth Factor I Activates c-Jun N-Terminal Kinase in MCF-7 Breast Cancer Cells1, Endocrinology, 141, 2, 2000. Crossref
-
Xu Zhao-Dong, Oey Lily, Mohan Subburaman, Kawachi Mark H., Lee Nan-Sook, Rossi John J., Fujita-Yamaguchi Yoko, Hammerhead Ribozyme-Mediated Cleavage of the Human Insulin-Like Growth Factor-II Ribonucleic Acid in Vitro and in Prostate Cancer Cells*, Endocrinology, 140, 5, 1999. Crossref
-
Garcia-Echeverria Carlos, Survival Signaling, in Cancer, 1, 2007. Crossref
-
Swantek Jennifer L., Baserga Renato, Prolonged Activation of ERK2 by Epidermal Growth Factor and Other Growth Factors Requires a Functional Insulin-Like Growth Factor 1 Receptor*, Endocrinology, 140, 7, 1999. Crossref
-
Wei Yong, Au Jessie L.-S., Role of Tumour Microenvironment in Chemoresistance, in Integration/Interaction of Oncologic Growth, 15, 2005. Crossref
-
Cooke David W., Divall Sara A., Radovick Sally, Normal and Aberrant Growth in Children, in Williams Textbook of Endocrinology, 2016. Crossref
-
Backeljauw Philippe F., Dattani Mehul Tulsidas, Cohen Pinchas, Rosenfeld Ron G., Disorders of growth hormone/insulin-like growth factor secretion and action, in Pediatric Endocrinology, 2014. Crossref
-
Houston Kevin D., Hunter Deborah S., Hodges Leslie C., Walker Cheryl L., Uterine Leiomyomas: Mechanisms of Tumorigenesis, Toxicologic Pathology, 29, 1, 2001. Crossref
-
Idelman Gila, Glaser Tova, Roberts Charles T., Werner Haim, WT1-p53 Interactions in Insulin-like Growth Factor-I Receptor Gene Regulation, Journal of Biological Chemistry, 278, 5, 2003. Crossref
-
Niu Xi-Lin, Li Juxiang, Hakim Zeenat S., Rojas Mauricio, Runge Marschall S., Madamanchi Nageswara R., Leukocyte Antigen-related Deficiency Enhances Insulin-like Growth Factor-1 Signaling in Vascular Smooth Muscle Cells and Promotes Neointima Formation in Response to Vascular Injury, Journal of Biological Chemistry, 282, 27, 2007. Crossref
-
Slattery Martha L., Samowitz Wade, Curtin Karen, Ma Khe Ni, Hoffman Michael, Caan Bette, Neuhausen Susan, Associations among IRS1, IRS2, IGF1, and IGFBP3 Genetic Polymorphisms and Colorectal Cancer, Cancer Epidemiology, Biomarkers & Prevention, 13, 7, 2004. Crossref
-
Lu Dan, Zhang Haifan, Ludwig Dale, Persaud Anita, Jimenez Xenia, Burtrum Douglas, Balderes Paul, Liu Meilin, Bohlen Peter, Witte Larry, Zhu Zhenping, Simultaneous Blockade of Both the Epidermal Growth Factor Receptor and the Insulin-like Growth Factor Receptor Signaling Pathways in Cancer Cells with a Fully Human Recombinant Bispecific Antibody, Journal of Biological Chemistry, 279, 4, 2004. Crossref
-
Okubo Yumiko, Blakesley Vicky A., Stannard Bethel, Gutkind Silvio, Le Roith Derek, Insulin-like Growth Factor-I Inhibits the Stress-activated Protein Kinase/c-Jun N-terminal Kinase, Journal of Biological Chemistry, 273, 40, 1998. Crossref
-
Yu Jennifer T., Foster Rosalinda G., Dean Douglas C., Transcriptional Repression by Rb-E2F and Regulation of Anchorage-Independent Survival, Molecular and Cellular Biology, 21, 10, 2001. Crossref
-
Du Jie, Brink Marijke, Peng Tao, Mottironi Bianca, Delafontaine Patrick, Thrombin Regulates Insulin-Like Growth Factor-1 Receptor Transcription in Vascular Smooth Muscle, Circulation Research, 88, 10, 2001. Crossref
-
Lu Dan, Zhang Haifan, Koo Henry, Tonra James, Balderes Paul, Prewett Marie, Corcoran Eric, Mangalampalli Venkata, Bassi Rajiv, Anselma Deborah, Patel Dipa, Kang Xiaoqiang, Ludwig Dale L., Hicklin Daniel J., Bohlen Peter, Witte Larry, Zhu Zhenping, A Fully Human Recombinant IgG-like Bispecific Antibody to Both the Epidermal Growth Factor Receptor and the Insulin-like Growth Factor Receptor for Enhanced Antitumor Activity, Journal of Biological Chemistry, 280, 20, 2005. Crossref
-
Slattery M. L., Sweeney C., Wolff R., Herrick J., Baumgartner K., Giuliano A., Byers T., Genetic variation in IGF1, IGFBP3, IRS1, IRS2 and risk of breast cancer in women living in Southwestern United States, Breast Cancer Research and Treatment, 104, 2, 2007. Crossref
-
Danilkovitch Alla, Donley Shannon, Skeel Alison, Leonard Edward J., Two Independent Signaling Pathways Mediate the Antiapoptotic Action of Macrophage-Stimulating Protein on Epithelial Cells, Molecular and Cellular Biology, 20, 6, 2000. Crossref
-
Girnita Leonard, Girnita Ada, Larsson Olle, Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor, Proceedings of the National Academy of Sciences, 100, 14, 2003. Crossref
-
Wu Jennifer D., Odman Austin, Higgins Lily M., Haugk Kathy, Vessella Robert, Ludwig Dale L., Plymate Stephen R., In vivo Effects of the Human Type I Insulin-Like Growth Factor Receptor Antibody A12 on Androgen-Dependent and Androgen-Independent Xenograft Human Prostate Tumors, Clinical Cancer Research, 11, 8, 2005. Crossref
-
Finkeltov Ina, Kuhn Scott, Glaser Tova, Idelman Gila, Wright John J, Roberts Charles T, Werner Haim, Transcriptional regulation of IGF-I receptor gene expression by novel isoforms of the EWS-WT1 fusion protein, Oncogene, 21, 12, 2002. Crossref
-
Rotem-Yehudar Rinat, Galperin Emilia, Horowitz Mia, Association of Insulin-like Growth Factor 1 Receptor with EHD1 and SNAP29, Journal of Biological Chemistry, 276, 35, 2001. Crossref
-
Ardini Elena, Agresti Roberto, Tagliabue Elda, Greco Marco, Aiello Piera, Yang Liang-Tung, Ménard Sylvie, Sap Jan, Expression of protein tyrosine phosphatase alpha (RPTPα) in human breast cancer correlates with low tumor grade, and inhibits tumor cell growth in vitro and in vivo, Oncogene, 19, 43, 2000. Crossref
-
van Golen C M, Castle V P, Feldman E L, IGF-I receptor activation and BCL-2 overexpression prevent early apoptotic events in human neuroblastoma, Cell Death & Differentiation, 7, 7, 2000. Crossref
-
Lu Yiling, Lin Yue-Zhen, LaPushin Ruth, Cuevas Bruce, Fang Xianjun, Yu Shuang Xing, Davies Michael A, Khan Humera, Furui Tatsuro, Mao Muling, Zinner Ralph, Hung Mien-Chi, Steck Peter, Siminovitch Kathy, Mills Gordon B, The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells, Oncogene, 18, 50, 1999. Crossref
-
Vernucci Maria, Cerrato Flavia, Besnard Nathalie, Casola Stefano, Pedone Paolo V, Bruni Carmelo B, Riccio Andrea, The H19 endodermal enhancer is required for Igf2 activation and tumor formation in experimental liver carcinogenesis, Oncogene, 19, 54, 2000. Crossref
-
Campbell Phil G., Durham Susan K., Hayes James D., Suwanichkul Adisak, Powell David R., Insulin-like Growth Factor-binding Protein-3 Binds Fibrinogen and Fibrin, Journal of Biological Chemistry, 274, 42, 1999. Crossref
-
Haider Tanweer, Kanwar Indu Lata, Pandey Vikas, Jain Priyanka, Soni Vandana, Tumor microenvironment-mediated targeted drug delivery to breast cancer cells, in Targeted Nanomedicine for Breast Cancer Therapy, 2022. Crossref