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Heat Transfer Research

Impact-faktor: 0.930

ISSN Druckformat: 1064-2285
ISSN Online: 2162-6561

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Heat Transfer Research

DOI: 10.1615/HeatTransRes.2012006425
pages 345-388

THERMAL ANALYSIS AND EXPERIMENTS OF LASER−TISSUE INTERACTIONS: A REVIEW

Amir Yousef Sajjadi
Department of Mechanical and Aerospace Engineering, Florida Institute of Technology, Melbourne, FL 32901, USA
Kunal Mitra
Department of Biomedical Engineering, Florida Institute of Technology, Melbourne, Florida, USA
Zhixiong Guo
Department of Mechanical and Aerospace Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA

ABSTRAKT

Studying the interaction of ultrashort pulse lasers with biological tissues and the corresponding mathematical modeling of possible thermal damage is of fundamental importance to the understanding of laser-tissue interaction for advancing surgical application of lasers. The objective of this paper is to review the existing techniques for thermal analysis of laser-tissue interaction, focusing on temperature rise and plasma-mediated ablation. Different laser-tissue interaction mechanisms are discussed, and the existing techniques for characterization of extent of damage are presented. A novel approach of using a focused laser beam from an ultrashort pulse laser source to ablate the subcutaneous tumors with minimal thermal effects is introduced. The extent of laser-induced damage is studied by determining the space-time expression patterns of heat shock proteins.