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Journal of Porous Media
Impact-faktor: 1.49 5-jähriger Impact-Faktor: 1.159 SJR: 0.43 SNIP: 0.671 CiteScore™: 1.58

ISSN Druckformat: 1091-028X
ISSN Online: 1934-0508

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Journal of Porous Media

DOI: 10.1615/JPorMedia.2020028229
pages 195-206

MEASUREMENT OF THE HYDRAULIC CONDUCTIVITY OF THE VITREOUS HUMOR

Anita N. Penkova
Department of Aerospace & Mechanical Engineering, USC Viterbi School of Engineering, University of Southern California, Los Angeles, California 90089-1453, USA; Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California 90027, USA
Shuqi Zhang
Department of Aerospace & Mechanical Engineering, USC Viterbi School of Engineering, University of Southern California, Los Angeles, California 90089-1453, USA
Mark S. Humayun
Department of Ophthalmology, USC Roski Eye Institute, Department of Integrative Anatomical Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California 90033-4682, USA; Department of Biomedical Engineering, USC Viterbi School of Engineering, University of Southern California, Los Angeles, California 90089-1111, USA
Scott Fraser
Department of Biomedical Engineering, USC Viterbi School of Engineering, University of Southern California, Los Angeles, California 90089-1111, USA; Departments of Molecular and Computational Biology, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California 90089-0371, USA
Rex Moats
Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, California 90027, USA; Department of Biomedical Engineering, USC Viterbi School of Engineering, University of Southern California, Los Angeles, California 90089-1111, USA
Satwindar Singh Sadhal
Department of Aerospace & Mechanical Engineering, USC Viterbi School of Engineering, University of Southern California, Los Angeles, California 90089-1453, USA; Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California 90027, USA; Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033-4682, USA

ABSTRAKT

The hydraulic conductivity of the vitreous humor has been measured for the bovine eye. The experiment was carried out by placing the vitreous within an upright cylindrical chamber, open at both ends, and letting its liquid content drain out of the bottom opening by gravity through a 20-μm nylon mesh filter. Additional negative pressure was provided at the exit by a hanging drainage tube. The diminishing vitreous volume was measured in terms of the height in the chamber and recorded as a function of time. The reduction in the vitreous liquid content also caused the hydraulic conductivity to reduce, and this parameter was quantified on the basis of previously developed theories of fibrous porous media that have been very well established. A theoretical model with a fully analytical expression for the vitreous volume undergoing drainage was developed and used as a least-squares best fit to deliver the initial hydraulic conductivity value of K0/μ = (7.8 ± 3.1) × 10-12 m2/(Pa s). The measurements were made with the hyaloid membrane intact and therefore represent an effective conductivity for the entire system, including possible variations within the vitreous.

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