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Critical Reviews™ in Biomedical Engineering
SJR: 0.26 SNIP: 0.375 CiteScore™: 1.4

ISSN Druckformat: 0278-940X
ISSN Online: 1943-619X

Volumes:
Volumen 48, 2020 Volumen 47, 2019 Volumen 46, 2018 Volumen 45, 2017 Volumen 44, 2016 Volumen 43, 2015 Volumen 42, 2014 Volumen 41, 2013 Volumen 40, 2012 Volumen 39, 2011 Volumen 38, 2010 Volumen 37, 2009 Volumen 36, 2008 Volumen 35, 2007 Volumen 34, 2006 Volumen 33, 2005 Volumen 32, 2004 Volumen 31, 2003 Volumen 30, 2002 Volumen 29, 2001 Volumen 28, 2000 Volumen 27, 1999 Volumen 26, 1998 Volumen 25, 1997 Volumen 24, 1996 Volumen 23, 1995

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.v39.i2.30
pages 125-180

Biomaterial Design Considerations for Repairing the Injured Spinal Cord

Ryan J. Gilbert
Regeneration and Repair Laboratory, Department of Biomedical Engineering, Michigan Technological University, Houghton, MI; Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY
Christopher J. Rivet
Regeneration and Repair Laboratory, Department of Biomedical Engineering, Michigan Technological University, Houghton, MI; Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY
Jonathan M. Zuidema
Regeneration and Repair Laboratory, Department of Biomedical Engineering, Michigan Technological University, Houghton, MI; Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY
Phillip G. Popovich
Department of Neuroscience and The Center for Brain and Spinal Cord Repair, The Ohio State University College of Medicine, Columbus, OH

ABSTRAKT

With increasing regularity, biomaterials are being designed with the goal of promoting repair of the injured spinal cord. Most often, the efficacy of novel biomaterials is tested using in vitro models; however, their true potential will be realized only after they are applied and evaluated in standardized in vivo spinal cord injury (SCI) models. The purpose of this review is to (1) provide a primer on SCI research including an overview of common pathogenic mechanisms that may respond to biomaterials and the in vivo models and outcomes assessment tools used to evaluate therapeutic efficacy; (2) review the types of biomaterials that have been tested in these models; (3) discuss which biomaterials might be applied to these models in the future; and (4) recommend future engineering strategies to create better in vivo models and assessment tools.


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