Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Critical Reviews™ in Biomedical Engineering
SJR: 0.207 SNIP: 0.376 CiteScore™: 0.79

ISSN Druckformat: 0278-940X
ISSN Online: 1943-619X

Volumes:
Volumen 47, 2019 Volumen 46, 2018 Volumen 45, 2017 Volumen 44, 2016 Volumen 43, 2015 Volumen 42, 2014 Volumen 41, 2013 Volumen 40, 2012 Volumen 39, 2011 Volumen 38, 2010 Volumen 37, 2009 Volumen 36, 2008 Volumen 35, 2007 Volumen 34, 2006 Volumen 33, 2005 Volumen 32, 2004 Volumen 31, 2003 Volumen 30, 2002 Volumen 29, 2001 Volumen 28, 2000 Volumen 27, 1999 Volumen 26, 1998 Volumen 25, 1997 Volumen 24, 1996 Volumen 23, 1995

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.v39.i4.50
pages 319-336

Computational Modeling of Airway and Pulmonary Vascular Structure and Function: Development of a "Lung Physiome"

Merryn Tawhai
University of Auckland
A. R. Clark
Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand
G. M. Donovan
Department of Mathematics, The University of Auckland, Auckland, New Zealand
K. S. Burrowes
Oxford University Computing Laboratory, University of Oxford, Oxford, United Kingdom

ABSTRAKT

Computational models of lung structure and function necessarily span multiple spatial and temporal scales, i.e., dynamic molecular interactions give rise to whole organ function, and the link between these scales cannot be fully understood if only molecular or organ-level function is considered. Here, we review progress in constructing multiscale finite element models of lung structure and function that are aimed at providing a computational framework for bridging the spatial scales from molecular to whole organ. These include structural models of the intact lung, embedded models of the pulmonary airways that couple to model lung tissue, and models of the pulmonary vasculature that account for distinct structural differences at the extra- and intra-acinar levels. Biophysically based functional models for tissue deformation, pulmonary blood flow, and airway bronchoconstriction are also described. The development of these advanced multiscale models has led to a better understanding of complex physiological mechanisms that govern regional lung perfusion and emergent heterogeneity during bronchoconstriction.


Articles with similar content:

ENERGY-PRESERVING MUSCLE TISSUE MODEL: FORMULATION AND COMPATIBLE DISCRETIZATIONS
International Journal for Multiscale Computational Engineering, Vol.10, 2012, issue 2
P. Le Tallec, M. Sorine, Dominique Chapelle, P. Moireau
Role of Airway Recruitment and Derecruitment in Lung Injury
Critical Reviews™ in Biomedical Engineering, Vol.39, 2011, issue 4
Y. Huang, Samir Ghadiali
What Does It Mean to be Human?
Ethics in Biology, Engineering and Medicine: An International Journal, Vol.3, 2012, issue 1-3
George D. Catalano
Fatigue Damage of Collagenous Tissues: Experiment, Modeling and Simulation Studies
Journal of Long-Term Effects of Medical Implants, Vol.25, 2015, issue 1-2
Caitlin Martin , Wei Sun
Emergent Structure-Function Relations in Emphysema and Asthma
Critical Reviews™ in Biomedical Engineering, Vol.39, 2011, issue 4
Bela Suki, Tilo Winkler