Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Critical Reviews™ in Biomedical Engineering
SJR: 0.26 SNIP: 0.375 CiteScore™: 1.4

ISSN Druckformat: 0278-940X
ISSN Online: 1943-619X

Volumen 48, 2020 Volumen 47, 2019 Volumen 46, 2018 Volumen 45, 2017 Volumen 44, 2016 Volumen 43, 2015 Volumen 42, 2014 Volumen 41, 2013 Volumen 40, 2012 Volumen 39, 2011 Volumen 38, 2010 Volumen 37, 2009 Volumen 36, 2008 Volumen 35, 2007 Volumen 34, 2006 Volumen 33, 2005 Volumen 32, 2004 Volumen 31, 2003 Volumen 30, 2002 Volumen 29, 2001 Volumen 28, 2000 Volumen 27, 1999 Volumen 26, 1998 Volumen 25, 1997 Volumen 24, 1996 Volumen 23, 1995

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.v34.i3.20
pages 215-271

Microdamage in Bone: Implications for Fracture, Repair, Remodeling, and Adaptation

Seth W. Donahue
Departments of Biomedical Engineering and Mechanical Engineering-Engineering Mechanics, Michigan Technological University, Houghton, Michigan
Sarah A. Galley
Departments of Biomedical Engineering and Mechanical Engineering-Engineering Mechanics, Michigan Technological University, Houghton, Michigan


Fatigue microdamage accumulates in bone as a result of physiological loading. The damage is often manifested as microcracks, which are typically 50−100 μm long. These types of cracks develop in the interstitial bone and frequently abut osteon cement lines. In vitro experimentation has shown that an accumulation of fatigue damage reduces the material properties of bone (e.g., elastic modulus). An accumulation of fatigue damage has been implicated in the etiology of stress fractures and fragility fractures. However, bone has a remarkable ability to detect and repair fatigue microdamage. This article reviews the experimental techniques for identifying and quantifying different types of microdamage in bone, the density of in vivo microcracks at different skeletal locations, the effect of microdamage on bone material properties, the role of microdamage in bone fracture, and the biological mechanisms for the detection and repair of fatigue microdamage.

Articles with similar content:

Is Soft Tissue Laxity Associated with Tissue Metal Concentrations after Total Knee Arthroplasty?
Journal of Long-Term Effects of Medical Implants, Vol.28, 2018, issue 2
Christina Arnholt, Meredith Perkins, Anita L. Kerkhof, Steven M. Kurtz, Julie Lowell, William M. Mihalko, Daniel MacDonald
Biomechanical Behavior and Viscoelastic Properties of Peripheral Nerves Subjected to Tensile Stress: Common Injuries and Current Repair Techniques
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.32, 2020, issue 3
Sophia Stasi, Georgios Papathanasiou, Georgios Papagiannis, Athanasios Triantafyllou, Elias C. Papadopoulos, Panayiotis J. Papagelopoulos, Evanthia Mitsiokapa, Panayiotis Koulouvaris, Konstantina G. Yiannopoulou
International Heat Transfer Conference 13, Vol.0, 2006, issue
Arun Majumdar, R. Wang, Rachel Segalman
DNA Repair Kinetic of Hydrogen Peroxide and UVA/B Induced Lesions in Peripheral Blood Leucocytes from Xeroderma Pigmentosum Patients and Healthy Subjects
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 4
Elio A. Prieto Gonzalez, Marta D. Mudry, Ana Maria Palermo
Glass Ionomer Cements: A Review of Composition, Chemistry, and Biocompatibility as a Dental and Medical Implant Material
Journal of Long-Term Effects of Medical Implants, Vol.15, 2005, issue 6
David Gore, James E. Haubenreich, Robert E. Kovarik