Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Plasma Medicine
SJR: 0.198 SNIP: 0.183 CiteScore™: 0.57

ISSN Druckformat: 1947-5764
ISSN Online: 1947-5772

Plasma Medicine

DOI: 10.1615/PlasmaMed.2017019479
pages 147-157

Mechanisms of Wound Healing and Disinfection in a Plasma Source for the Treatment of Corneal Infections

Paola Brun
Dipartimento di Medicina Molecolare, Unità di Microbiologia, Università di Padova, Italy
A. Pellizzaro
University of Padua, Department of Molecular Medicine, Unit of Microbiology, Padua, Italy
Roberto Cavazzana
Consorzio RFX, Padova, Italy
L. Cordaro
Consorzio RFX, Padua, Italy
Matteo Zuin
Consorzio RFX, Padova, Italy
Emilio Martines
Consorzio RFX, Padova, Italy


Cold atmospheric pressure plasmas provide the potential for effective treatment of infectious keratitis, a sight-threatening process with a worldwide occurrence of 2 million cases/yr. In microbial keratitis, bacteria, fungi, viruses, or small eukaryotes penetrate and proliferate in the cornea, causing inflammation and tissue ulceration. The requirement of clinical approaches to overcome antibiotic resistance and simultaneously foster tissue healing prompted us to develop a plasma source generated by ionizing helium flow for ophthalmologic applications. Using plasma, we reported significant reductions in load of bacteria, virus, and fungi that are frequently involved in infectious keratitis. Plasma exposure induced formation of reactive oxygen and nitrogen species in human cells, accounting for the already described biological effects. Actually, nontoxic levels of reactive species elicit intracellular signals and modulate hypoxia-related gatekeeper transcriptional factors such as nuclear factor-κB and hypoxia-inducible factor-1α. Together, these data make cold atmospheric pressure plasma generated by ionizing helium flow a valid approach for the treatment of infectious keratitis.

Articles with similar content:

Using Helium-Generated Cold Plasma to Control Infection and Healing
Plasma Medicine, Vol.5, 2015, issue 2-4
Velika Deligianni, Paola Brun, Andrea Leonardi, Elena Tarricone, Roberto Cavazzana, Simona Corrao, Venera Russo, Matteo Zuin, Emilio Martines
Involvement of Different Genes Expressions during Immunological and Inflammatory Responses in Vitiligo
Critical Reviews™ in Eukaryotic Gene Expression, Vol.27, 2017, issue 3
Monika Sharma, Chandra Kant Sharma, Kanika Prasad
Hot Water Extract of the Sclerotium of Polyporus rhinocerus Cooke Enhances the Immune Functions of Murine Macrophages
International Journal of Medicinal Mushrooms, Vol.13, 2011, issue 3
Cuixia Guo, Ka-Hing Wong, Peter Chi Keung Cheung
Inactivation of Hepatitis C Virus Cells Using Gliding Arc Discharge
Plasma Medicine, Vol.5, 2015, issue 1
Gamal M. El-Aragi
Endothelial Responses to Bacterial Toxins in Sepsis
Critical Reviews™ in Immunology, Vol.23, 2003, issue 4
Friedrich Grimminger, Ulrich Grandel