Abo Bibliothek: Guest
Plasma Medicine

Erscheint 4 Ausgaben pro Jahr

ISSN Druckformat: 1947-5764

ISSN Online: 1947-5772

SJR: 0.216 SNIP: 0.263 CiteScore™:: 1.4 H-Index: 24

Indexed in

Induction of Apoptosis by Cold Atmospheric Pressure Plasma for Oral Squamous Cell Carcinoma Cells

Volumen 8, Ausgabe 4, 2018, pp. 411-418
DOI: 10.1615/PlasmaMed.2019028601
Get accessDownload

ABSTRAKT

Cold atmospheric pressure plasma (CAPP) techniques have developed rapidly during the last decades and have become an important field in plasma medicine. Plasma is ionized gas that is comprised of reactive atoms, molecules, ions, and radicals. CAPP generates various types of highly reactive oxygen and nitrogen species at room temperature that play an important part in biological applications including cancer therapy. In recent years, CAPP has gained increasingly more interest among cancer researchers, but the mechanism of CAPP's effect is not fully understood. The aim of this study is to investigate both the mechanism of CAPP on oral squamous cell carcinoma (OSCC) cells as well as plasma-induced radicals. We observe plasma-induced highly reactive species in a plasma plume and cell culture. A cell proliferation assay shows that CAPP significantly decreases proliferation of oral squamous cells in vitro. Western blot analysis shows cleavage of poly (ADP-ribose) polymerase protein after plasma treatment, indicating that CAPP can induce cell death via the apoptosis pathway. These findings show that CAPP could be used as an alternative adjuvant therapeutic tool for the treatment of OSCC.

REFERENZEN
  1. Kong MG, Kroesen G, Morfill G, Nosenko T, Shimizu T, van Dijk J, Zimmermann JL. Plasma medicine: An introductory review. New J Phys. 2009;11(11):115012.

  2. Mai-Prochnow A, Murphy AB, McLean KM, Kong MG, Ostrikov KK. Atmospheric pressure plasmas: Infection control and bacterial responses. Int J Antimicrob Agents. 2014;43(6):508-17.

  3. Rupf S, Lehmann A, Hannig M, Schafer B, Schubert A, Feldmann U, Schlindler A. Killing of adherent oral microbes by a non-thermal atmospheric plasma jet. J Med Microbiol. 2010;59(Pt 2):206-12.

  4. Nosenko T, Shimizu T, Morfill GE. Designing plasmas for chronic wound disinfection. New J Phys. 2009;11(11):115013.

  5. Fridman G, Friedman G, Gutsol A, Shekhter AB, Vasilets VN, Fridman A. Applied plasma medicine. Plasma Proc Polym. 2008;5(6):503-33.

  6. Sensenig R, Kalghatgi S, Cerchar E, Fridman G, Shereshevsky A, Torabi B, Arjunan KP, Podolsky E, Fridman A, Friedman G, Azizkhan-Clifford J, Brooks AD. Non-thermal plasma induces apoptosis in melanoma cells via production of intracellular reactive oxygen species. Ann Biomed Eng. 2011;39(2):674-87.

  7. Vandamme M, Robert E, Lerondel S, Sarron V, Ries D, Dozias S, Sobilo J, Gosset D, Kieda C, Legrain B, Pouvesle JM, Pape AL. ROS implication in a new antitumor strategy based on nonthermal plasma. Int J Cancer. 2012;130(9):2185-94.

  8. Chang JW, Kang SU, Shin YS, Seo SJ, Kim YS, Yang SS, Lee JS, Moon E, Lee K, Kim CH. Combination of NTP with cetuximab inhibited invasion/migration of cetuximab-resistant OSCC cells: Involvement of NF-KB signaling. Sci Rep. 2015;5:18208.

  9. Argiris A, Karamouzis MV, Raben D, Ferris RL. Head and neck cancer. Lancet. 2008;371(9625): 1695-709.

  10. Keidar M, Shashurin A, Volotskova O, Stepp MA, Srinivasan P, Sandler AD, Trink B. Cold atmospheric plasma in cancer therapy. Phys Plasmas. 2013;20(5):057101.

  11. Kim SJ, Chung TH. Plasma effects on the generation of reactive oxygen and nitrogen species in cancer cells in-vitro exposed by atmospheric pressure pulsed plasma jets. Appl Phys Lett. 2015;107(6):063702.

  12. Ahn HJ, Kim KI, Kim G, Moon E, Yang SS, Lee JS. Atmospheric-pressure plasma jet induces apoptosis involving mitochondria via generation of free radicals. PLoS One. 2011;6(11):e28154.

  13. Kim CH, Kwon S, Bahn JH, Lee K, Jun SI, Rack PD, Baek SJ. Effects of atmospheric nonthermal plasma on invasion of colorectal cancer cells. Appl Phys Lett. 2010;96(24):243701.

  14. Kalghatgi S, Kelly CM, Cerchar E, TorabiB, Alekseev O, FridmanA, Friedman G, Azizkhan-Clifford J. Effects of non-thermal plasma on mammalian cells. PLoS One. 2011;6(l):el6270.

  15. Chang JW, Kang SU, Shin YS, Kim KI, Seo SJ, Yang SS, Lee JS, Moon E, Baek SJ, Lee K, Kim CH. Non-thermal atmospheric pressure plasma induces apoptosis in oral cavity squamous cell carcinoma: Involvement of DNA-damage-triggering sub-G1 arrest via the ATM/p53 pathway. Arch Biochem Biophys. 2014;545:133-40.

  16. Heaselgrave W, Shama G, Andrew PW, Kong MG. Inactivation ofAcanthamoeba spp. and other ocular pathogens by application of cold atmospheric gas plasma. Appl Env Microbiol. 2016;82(10):3143-8.

  17. Goldman R, Pollack S. Electric fields and proliferation in a chronic wound model. Bioelectromagnetics. 1996;17(6):450-7.

  18. Ahn HJ, Kim KI, Hoan NN, Kim CH, Moon E, Choi KS, Yang SS, Lee JS. Targeting cancer cells with reactive oxygen and nitrogen species generated by atmospheric-pressure air plasma. PLoS One. 2014;9(1):e86173.

  19. Liu JR, Xu GM, Shi XM, Zhang GJ. Low temperature plasma promoting fibroblast proliferation by activating the NF-KB pathway and increasing cyclin D1 expression. Sci Rep. 2017;7(1):11698.

  20. Kang SU, Seo SJ, Kim YS, Shin YS, Koh YW, Lee CM, Yang SS, Lee JS, Moon E, Kang H, Ryeo JB, Lee Y, Kim CH. Comparative effects of non-thermal atmospheric pressure plasma on migration and invasion in oral squamous cell cancer, by gas type. Yonsei Med J. 2017;58(2):272-81.

  21. Iseki S, Nakamura K, Hayashi M, Tanaka H, Kondo H, Kajiyama H, Kano H, Kikkawa F, Hori M. Selective killing of ovarian cancer cells through induction of apoptosis by nonequilibrium atmospheric pressure plasma. Appl Phys Lett. 2012;100(11):113702.

  22. Koritzer J, Boxhammer V, Schafer A, Shimizu T, Klampfl TG, Li YF, Welz C, Schwenk-Zieger S, Morfill GE, Zimmermann JL, Schlegel J. Restoration of sensitivity in chemo-resistant glioma cells by cold atmospheric plasma. PLoS One. 2013;8(5):e64498.

  23. Ishaq M, Kumar S, Varinli H, Han ZJ, Rider AE, Evans MD, Murphy AB, Ostrikov K. Atmospheric gas plasma-induced ROS production activates TNF-ASK1 pathway for the induction of melanoma cancer cell apoptosis. Mol Biol Cell. 2014;25(9):1523-31.

REFERENZIERT VON
  1. Berner Julia, Seebauer Christian, Sagwal Sanjeev Kumar, Boeckmann Lars, Emmert Steffen, Metelmann Hans-Robert, Bekeschus Sander, Medical Gas Plasma Treatment in Head and Neck Cancer—Challenges and Opportunities, Applied Sciences, 10, 6, 2020. Crossref

  2. Pasqual-Melo Gabriella, Nascimento Thiago, Sanches Larissa Juliani, Blegniski Fernanda Paschoal, Bianchi Julya Karen, Sagwal Sanjeev Kumar, Berner Julia, Schmidt Anke, Emmert Steffen, Weltmann Klaus-Dieter, von Woedtke Thomas, Gandhirajan Rajesh Kumar, Cecchini Alessandra Lourenço, Bekeschus Sander, Plasma Treatment Limits Cutaneous Squamous Cell Carcinoma Development In Vitro and In Vivo, Cancers, 12, 7, 2020. Crossref

  3. Choi Jeong-Hae, Gu Hee-Jin, Park Kwang-Ha, Hwang Dae-Seok, Kim Gyoo-Cheon, Anti-Cancer Activity of the Combinational Treatment of Noozone Cold Plasma with p-FAK Antibody-Conjugated Gold Nanoparticles in OSCC Xenograft Mice, Biomedicines, 10, 9, 2022. Crossref

Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen Preise und Aborichtlinien Begell House Kontakt Language English 中文 Русский Português German French Spain