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Plasma Medicine
SJR: 0.271 SNIP: 0.316 CiteScore™: 1.9

ISSN Druckformat: 1947-5764
ISSN Online: 1947-5772

Plasma Medicine

DOI: 10.1615/PlasmaMed.2018024767
pages 73-82

Antibacterial Efficacy of Plasma Jet, Dielectric Barrier Discharge, Chlorhexidine, and Silver Diamine Fluoride Varnishes in Caries Lesions

Moritz Hertel
Department of Oral Medicine, Dental Radiology and Oral Surgery, Charite-Universitatsmedizin Berlin, Berlin, Germany
Julia Schwill-Engelhardt
Department of Operative and Preventive Dentistry, Charité-Universitätsmedizin Berlin, Berlin, Germany
Torsten Gerling
Leibniz Institute of Plasma Science and Technology (INP Greifswald), Greifswald, Germany
Klaus-Dieter Weltmann
Leibniz-Institute for Plasma Science and Technology (INP Greifswald), ZIK Plasmatis, Greifswald, Germany
Sandra Maria Imiolczyk
Department of Operative and Preventive Dentistry, Charité-Universitätsmedizin Berlin, Berlin, Germany
Stefan Hartwig
Department of Oral and Maxillofacial and Facial Plastic Surgery, Johannes Wesling Hospital Minden, University Hospital of Ruhr University, Bochum, Germany
Saskia Preissner
Department of Operative and Preventive Dentistry, Charité-Universitätsmedizin Berlin, Berlin, Germany


The aim of this study was to assess the bactericidal efficacy of cold atmospheric plasmas (CAPs), chlorhexidine (CHX), and silver diamine fluoride (SDF) in root caries lesions (RCLs). Artificial RCLs were created in 50 human dentin samples using a computer-controlled continuous-culture biofilm model. Subsequently, CAPs (created using a plasmajet, CAP I, or a dielectric barrier discharge source, CAP II,CHX, and SDF varnishes were used in antibacterial treatment, and the number of viable bacteria was determined. To compare the different plasma sources, filament quantification was performed using an oscilloscope. All applied agents led to significantly lower counts of colony-forming units (CFUs) compared to the control (p ≤ 0.01; Mann-Whitney U test). The obtained logarithmic reduction factors of CAP I, CAP II, CHX, and SDF were 1.18, 0.61, 0.81, and 1.95, respectively. Only the results for SDF and CAP II differed significantly (p = 0.004). Filamentation imaging revealed approximately 3 × 107 filaments for CAP I and 3 × 105 for CAP II within 60 s. Compared to the control, all investigated agents significantly reduced CFU numbers in artificial RCLs. Among those, the effect of SDF was superior to that of CAP II. All investigated agents provided antibacterial effects and may therefore be used for the noninvasive treatment of RCLs.

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