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Atomization and Sprays

Erscheint 12 Ausgaben pro Jahr

ISSN Druckformat: 1044-5110

ISSN Online: 1936-2684

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00095 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.28 SJR: 0.341 SNIP: 0.536 CiteScore™:: 1.9 H-Index: 57

Indexed in

LARGE EDDY SIMULATION OF POLYDISPERSE PARTICLE DEPOSITION IN AN IDEALIZED MOUTH-THROAT

Volumen 28, Ausgabe 2, 2018, pp. 179-193
DOI: 10.1615/AtomizSpr.2018025127
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ABSTRAKT

The present study investigates the polydisperse particle deposition in an idealized mouth-throat. The scope is the identification of the properties of polydisperse particle deposition in the human upper airways with respect to the aerosol drug delivery to the lung. Both one-way and two-way coupling between the gas and the particle phases are implemented to model the two-phase flow. Large eddy simulation (LES) with the Smagorinsky subgrid model is used to simulate the laminar-transitional-turbulent gas flow, and themodel is combined with Lagrangian equations to describe the particle motion. User-defined solvers based on the open-source software OpenFOAM are developed to solve the governing equations. An experimental particle size distribution from a dry powder inhaler with 200 μg dosage corresponding to one actuation is used. The numerical results show that the polydisperse particle deposition in the human mouth-throat is dominated by the particle size distribution and the geometric characteristics of the idealized mouth-throat. Moreover, simulations with two different monodisperse aerosols with different particle sizes are used for comparison: the representative Sauter mean diameter and the mass median diameter of the reference polydisperse particle size distribution. The particle deposition efficiency of the polydisperse particle distribution is much higher than that of both monodisperse particle distributions, which cannot represent the polydisperse particle deposition characteristics. The particle deposition efficiency is higher using one-way coupling compared to two-way coupling for the polydisperse particle size distribution. It is concluded that a representative polydisperse particle distribution should be used to simulate the aerosol drug deposition in the human respiratory system using two-way coupling.

REFERENZIERT VON
  1. Cui Xinguang, Wu Wenwang, Ge Haiwen, Investigation of airflow field in the upper airway under unsteady respiration pattern using large eddy simulation method, Respiratory Physiology & Neurobiology, 279, 2020. Crossref

  2. Cui Xinguang, Ge Haiwen, Wu Wenwang, Feng Yaning, Wang Jintao, LES study of the respiratory airflow field in a whole-lung airway model considering steady respiration, Journal of the Brazilian Society of Mechanical Sciences and Engineering, 43, 3, 2021. Crossref

  3. Elwekeel Fifi N. M., Cui Xinguang, Abdala Antar M. M., Effects of chlorine particle concentration on the human airway, Journal of Nanoparticle Research, 24, 6, 2022. Crossref

  4. Wang Li, Ge Haiwen, Chen Liang, Hajipour Alireza, Feng Yaning, Cui Xinguang, LES study on the impact of airway deformation on the airflow structures in the idealized mouth–throat model, Journal of the Brazilian Society of Mechanical Sciences and Engineering, 44, 1, 2022. Crossref

  5. Talaat Mohamed, Si Xiuhua, Liu Xiaofei, Xi Jinxiang, Count- and mass-based dosimetry of MDI spray droplets with polydisperse and monodisperse size distributions, International Journal of Pharmaceutics, 623, 2022. Crossref

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