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ISSN Druckformat: 1044-5110
ISSN Online: 1936-2684
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USE OF WATER DEPOSITION TO STUDY THE MAIN FACTORS IN WALL COLLISIONS OF DROPLETS IN A PHARMACEUTICAL-SCALE SPRAY DRYER
ABSTRAKT
Experiments were conducted to investigate the effect of different operating conditions on the process of wall deposition in a Büchi B290 pharmaceutical-type spray dryer, with a drying chamber diameter of 0.155 m and a main chamber height of 0.48 m. In the experiments, liquid flow rates were between 7 and 28 mL/min, airflow rates to the atomizer were between 170 and 670 L/hr, and main airflow rates through the dryer were between 20 and 38 m3 /hr. The results suggested that the droplet concentration is more important than the initial droplet velocity in determining the rates of collision with walls. The collision of cold water droplets was simulated using a mathematical model based on tracking droplet trajectories, and the simulations of the deposition behavior give important guidance in interpreting the deposition mechanisms in the experimental results.
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Das Debolina, Langrish Timothy A. G., Combined Crystallization and Drying in a Pilot-Scale Spray Dryer, Drying Technology, 30, 9, 2012. Crossref
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Schaefer Joachim, Lee Geoffrey, Making large, flowable particles of protein or disaccharide in a mini-scale spray dryer, Pharmaceutical Development and Technology, 2015. Crossref