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Critical Reviews™ in Eukaryotic Gene Expression

Erscheint 6 Ausgaben pro Jahr

ISSN Druckformat: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Control of Tooth Morphogenesis by Runx2

Volumen 16, Ausgabe 2, 2006, pp. 143-154
DOI: 10.1615/CritRevEukarGeneExpr.v16.i2.30
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ABSTRAKT

Odontogenesis is a complex process in which the interplay of signaling cascades of the epithelium and mesenchyme is critical. Evidence for the involvement of Runx2−a well-known osteogenic master transcription factor−in odontogenesis, has been accumulating. Haploinsufficiency of Runx2 in humans results in cleido-cranial dysplasia (CCD), characterized by supernumerary teeth; in Runx2−/− mice, molar odontogenesis does not proceed beyond the late bud stage. In this article, we discuss the role of Runx2 in tooth development, specifically in the signaling interplay of the epithelium and mesenchyme during the transition from bud stage to cap stage. Runx2 is an important molecule of the dental mesenchyme; its expression is induced by epithelial fibroblast growth factor (FGF), and it is involved in regulating the induction of mesenchymal signaling back to the dental epithelium for epithelial morphogenesis. In addition, we discuss the role of the two major isoforms of Runx2, and other Runx family genes, in odontogenic processes.

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